AutismKB 2.0

Annotation Detail for SLC7A6


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Basic Information Top
Gene Symbol:SLC7A6 ( DKFZp686K15246,KIAA0245,LAT-2,LAT3,y+LAT-2 )
Gene Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
Band: 16q22.1
Quick LinksEntrez ID:9057; OMIM: 605641; Uniprot ID:YLAT2_HUMAN; ENSEMBL ID: ENSG00000103064; HGNC ID: 11064
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Transmembrane transport of small molecules
Amino acid and oligopeptide SLC transporters
Hemostasis
Metabolism of amino acids and derivatives
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SLC7A6 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC7A6 proteinaffects expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC7A6 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of SLC7A6 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SLC7A6 mRNAaffects expression 17555576
D013629 Tamoxifen Tamoxifen affects the expression of SLC7A6 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Tamoxifen 2.1818997820 20859285 20544844 17440819 18425577 19487384 11161223 19011961 19189210 17242785 15668708 21138602 20065188 21152245 19066611 17049068 19103187 16273361 18351453 17261762 15565566 19410462 16818667 19059307 18821012 19084267 18629630 19200415 16202921 20390343 19244106 16873071 20005174 19288272 18855134 19189212 18815881 17893378 19155303 18984771 20135344 19289846 19221464 19115204 19142967
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.773084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7712907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7716924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.2612371664
MESH:D002779 Cholestasis Cyclosporine 8.5519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5517110522 16105132 17681005 15861022 16919318 11677210 17333356
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6512540782 19370779 19923254 19085960 11739529 19416960 16781746 11834606 12153990 14986274 15619225 11287661 14550746 10774834 19739265 16177239 11743745 12392966 10663392 16227642 2444490 19420014 14725611 16081117 18713872 18071297 11529661 17562736 16393943 16485898 10915739 17906064 11421492 16109766 17522070 12594235 19164858 12705907 15968718 12958197 11461765
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2420544844 17893378 16202921 19155303
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Cyclosporine 15.0219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0215345470
MESH:D005234 Fatty Liver Tamoxifen 15.0214986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005355 Fibrosis Cyclosporine 3.5612639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006973 Hypertension Cyclosporine 2.1910903974
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.3415629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.348314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 8.2012371664
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2018625569
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 12969438 11587558 19784758 16611625 19014921 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.9618177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Tamoxifen 4.9616684651
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.928603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5514755239
MESH:D008175 Lung Neoplasms Tamoxifen 2.5518625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8116827153 19196722 11731420 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19200415 19196722
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5719348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.458653321 17572228 16712894
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8715869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:19419 Amino acid and oligopeptide SLC transporters
REACT:604 Hemostasis
REACT:13 Metabolism of amino acids and derivatives
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35924
    • No data
    No data
    Releated drug ID Related drug Name
    PA449789glycine
    PA448055l-alanine
    PA448478l-arginine
    PA449173l-cysteine
    PA450197l-leucine
    PA450280l-lysine
    PA451125l-proline
    PA451330l-serine
    PA451822l-tyrosine
    PA451843l-valine
    PA451590taurine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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