AutismKB 2.0

Annotation Detail for PAPSS2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PAPSS2 ( ATPSK2,SK2 )
Gene Full Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Band: 10q23.2-q23.31
Quick LinksEntrez ID:9060; OMIM: 603005; Uniprot ID:PAPS2_HUMAN; ENSEMBL ID: ENSG00000198682; HGNC ID: 8604
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5340sulfate activation for sulfonation
Pathway IDPathway Name
hsa00920Sulfur metabolism
hsa00230Purine metabolism
hsa00450Selenoamino acid metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Biological oxidations
No data
Pathway IDPathway Name
P02778Sulfate assimilation
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
exercise (leisure time)
Desease Name
Exercise (leisure time)
Desease Name
SEMD, Pakistani type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PAPSS2 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PAPSS2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PAPSS2 mRNAincreases expression 18648102
C080417 4-octylphenol 4-octylphenol results in decreased expression of PAPSS2 mRNAdecreases expression 16223563
D000082 Acetaminophen Acetaminophen affects the expression of PAPSS2 mRNAaffects expression 17562736
C068073 Am 580 Am 580 results in increased expression of PAPSS2 mRNAincreases expression 16982809
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PAPSS2 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of PAPSS2 mRNAincreases expression 15336504
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of PAPSS2 mRNAdecreases expression 18178546
D019826 Cholic Acid Cholic Acid results in increased expression of PAPSS2 mRNAincreases expression 17521389
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PAPSS2 mRNAaffects cotreatment|affects expression 17602206
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of PAPSS2 mRNAdecreases expression 16223563
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PAPSS2 mRNAaffects cotreatment|affects expression 17602206
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PAPSS2 mRNAincreases expression 17005392
C042080 diisodecyl phthalate diisodecyl phthalate results in decreased expression of PAPSS2 mRNAdecreases expression 16223563
D004958 Estradiol Estradiol affects the expression of PAPSS2 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PAPSS2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of PAPSS2 mRNAincreases expression 19619570
D005480 Flurbiprofen Flurbiprofen results in increased expression of PAPSS2 mRNAincreases expression 16949054
D010634 Phenobarbital Phenobarbital results in increased expression of PAPSS2 mRNAincreases expression 19482888
19270015
C089730 rosiglitazone rosiglitazone results in increased expression of PAPSS2 mRNAincreases expression 16982809
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PAPSS2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PAPSS2 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PAPSS2 mRNAdecreases expression 19933214
D014635 Valproic Acid Valproic Acid results in increased expression of PAPSS2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 19.496734493
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 19.496195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 19.4914514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 19.498875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.8319490988
MESH:D000230 Adenocarcinoma Estradiol 2.0711473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.463712494
MESH:D000236 Adenoma Diethylnitrosamine 6.466695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.7217620307 18056438 19052882 17162532 19061943 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.7217620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.7216835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.9710680582
MESH:D000544 Alzheimer Disease rosiglitazone 2.8319621015
MESH:D000550 Amblyopia Valproic Acid 5.1317688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D000799 Angioedema Acetaminophen 3.7410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4817497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518396377 20603192 19460635 18775368 19232924 18177632 17507914 18985861 17688650 15238991 17157402 18316065 18940202 16609825 18558336
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.911440618 11289319
MESH:D001714 Bipolar Disorder Valproic Acid 3.0217594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7915746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.798888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9315324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 1.9319861407 17289903 17261762 12948864 17018787 16675129 14630087 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.8316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.837296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.833084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.8316698587 19701751 20214788 3084413 18691550 19335982 19919837 16288022 11831363 17173139 10737359 19052882 17162532 10672840 18785209 17978847 18978308 19539802 20101231 19519916 20524982 3581430 19822196 18393292 18056438 20727157 20432363 17055752 21159647 16502159 18665156 17761372 16681979 18210153 20007298 18506893 16935385 16878318 19208518 17428255 18494052 18788625 19107877 20084675 19383236 19171122 18971187 20514400 19418558 20935162 16569478 17138121 20512989 19394651 16807293 16328049 16779866 16540662 16830150
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.8315948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.8316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.8317173139 1701930 20935162 20007298 6705139
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.627296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3118850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.4710977129
MESH:D002386 Cataract Am 580 7.4717460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.397505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.3920889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.3917174075 21159647 7505956 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.3918566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.144080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6720734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.069022650 19486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0612621046 16354765 15668235 8697196 15340226
MESH:D003092 Colitis Am 580 4.8517035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4415322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4417688650 16575769 8888407
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.4512952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.9118551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.708156756 12868966 2524372 18759878 11906362 14531868 8970840 11298694
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 4.0016882537
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.393621924 2952479
MESH:D003920 Diabetes Mellitus rosiglitazone 4.2017446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.0120387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 7.0112642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.0117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.2018692083 16192314 9653073 11289319 18289764 6482804 8291058 9328219 7440962 18648102 6679447 1440618 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.2019923254 16081117 11739529 11461765 16393943 14725611 10774834 17906064 18713872 11421492 12540782 11834606 19420014 10915739 16485898 12705907 16177239 12153990 19370779 16227642 12594235 18071297 17562736 14986274 14550746 16109766 15968718 10663392 15619225 19416960 11529661 12958197 12392966 17522070 19164858 16781746 11743745 19739265 19085960 11287661 2444490
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 18.2017851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.2019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.2020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 18.201733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D004421 Dystonia Phenobarbital 10.091851702
MESH:D004421 Dystonia Valproic Acid 10.091851702
MESH:D004487 Edema rosiglitazone 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8018230668 15322242 16714409
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.3115700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 7.3119148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.433659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.4317275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 9.623922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.623922381 16628512
MESH:D004827 Epilepsy Phenobarbital 6.4820417680
MESH:D004827 Epilepsy Valproic Acid 6.4818234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 8.556401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.556426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 10.947750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 10.947750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.123659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.123659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.293581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.2920426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9311564622
MESH:D005234 Fatty Liver Diethylnitrosamine 12.6820387270 21071580
MESH:D005234 Fatty Liver rosiglitazone 12.6819196556
MESH:D005234 Fatty Liver Valproic Acid 12.6819224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5916534752 16002989 15751030 16513791 16611131
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7816575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.028888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.916705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8420067830
MESH:D005756 Gastritis Acetaminophen 3.5716983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.8416452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.937505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.416705139
MESH:D006529 Hepatomegaly Phenobarbital 8.0816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0816120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.9315709030
MESH:D019584 Hot Flashes Estradiol 3.6517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9415340226 16354765 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 7.5916870215
MESH:D006930 Hyperalgesia rosiglitazone 7.5912083418
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.4715034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.4712960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8718850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 4.4716002989
MESH:D007246 Infertility Diethylstilbestrol 4.2515036965
MESH:D007249 Inflammation Diethylnitrosamine 11.5818785209
MESH:D007249 Inflammation Flurbiprofen 11.5811099482
MESH:D007249 Inflammation rosiglitazone 11.5812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.5812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.3916627594 16393666
MESH:D007333 Insulin Resistance rosiglitazone 7.3916306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.918074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2316580747
MESH:D007674 Kidney Diseases Acetaminophen 5.6715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 5.6715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.0216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 17.026582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 17.0216762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 17.0215610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.9517184923
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1317596541 16294345
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4418665156 18407596 20032147 18522880 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 6.4421047994
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.139327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.4615980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 6.3212969438 16610002 19014921 16611625 11587558 19784758 12587719 19460945
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3217034775
MESH:D008107 Liver Diseases Phenobarbital 6.3219363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1417185352 16871587
MESH:D008113 Liver Neoplasms Clofibric Acid 17.4617602206
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 17.4611940454
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.4620492335 19294768 19850985 19499222 21167192 18644402 21071580 20137499 20434301 12771043 20118626 19256749 2862719 20405173 2422723 19833225 18648771 12112319 20101389 19812893 19254457 19426721 21047994 21278145 19427195 19690152 19551842 20452335 20583210 19638242 19996281 9163691 15885732 18754104 19073162 19642983 18978307 10737359 18977376 16942905 15175105 19255062 19090486 20501860
MESH:D008113 Liver Neoplasms Diethylstilbestrol 17.4616712894 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 17.4619073162 21047994 15975961 8742319 19812893 19482888
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.4616984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 13.541399818 6587162 598648 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.5417174075 17942915 3124819 18093689 9362446 19009564 18164116 18544905 18308698 19539802 19004024 16267830 16842330 18775883 18253720 18079962 18282651 17854601 2563599 19126423 19519916 21159647
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.546150874 1399818 17172636 2563599 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.5412151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1617228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.226695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2211884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.0415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4116002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.0211408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 6.0216827153
MESH:D020149 Manganese Poisoning Estradiol 4.3819453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4619513568
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.2817261469
MESH:D008881 Migraine Disorders Valproic Acid 3.1118803445 18765137
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.928888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0917596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1916810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3717484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.7518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.563581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.569029167 3581430
MESH:D009369 Neoplasms Diethylstilbestrol 2.7115313581
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6217289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.7611399458
MESH:D009421 Nervous System Malformations Estradiol 15.7616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.7614600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.026679447
MESH:D009436 Neural Tube Defects Valproic Acid 7.028888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0120387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.5516049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 8.554026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.913988306
MESH:D010018 Osteomalacia Phenobarbital 4.2617016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.1919401270
MESH:D010146 Pain Acetaminophen 2.3016870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.1316540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.1316965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.387296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.366228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.0614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.5615687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.772563599
MESH:D011230 Precancerous Conditions Phenobarbital 8.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.6417184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.6411222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 15.6420603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7820887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.8115846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.8116740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 2.8117409433
MESH:D019310 Pseudolymphoma Phenobarbital 11.8412752131
MESH:D019310 Pseudolymphoma Valproic Acid 11.8411422049 12752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.293692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0719155313
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.4018551238
MESH:D012640 Seizures Phenobarbital 9.4016876388 11442880 3137016 4039156
MESH:D012640 Seizures Valproic Acid 9.4015475178 14763951 11044598 16876388 3137016 1511512 11738929 17978042
MESH:D003294 Seizures, Febrile Phenobarbital 4.716407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.428532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4216192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.6116002989 16709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6919490988
OMIM:612847 SPONDYLOEPIMETAPHYSEAL DYSPLASIA, PAKISTANI TYPE marker/mechanism
MESH:D013226 Status Epilepticus Valproic Acid 4.4412833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.466587162 3712494 1399818 6582329 7505956
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.467505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.461399818
MESH:D013978 Tibial Fractures Estradiol 4.5819048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.1317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.413119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.0916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.098074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.0917306315 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.538888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.2110091137
MESH:D014581 Urticaria Acetaminophen 2.8710982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.9416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.0614652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.9615809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.3316002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
Pathway ID Pathway Name
REACT:13433 Biological oxidations
KEGG:01100 Metabolic pathways
KEGG:00230 Purine metabolism
KEGG:00450 Selenocompound metabolism
KEGG:00920 Sulfur metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA383
    • No data
    Releated disease ID Related disease Name
    PA447305spondyloepimetaphyseal dysplasia
    Releated drug ID Related drug Name
    PA452604xenobiotics
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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