AutismKB 2.0

Annotation Detail for PIAS2


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Basic Information Top
Gene Symbol:PIAS2 ( MGC102682,MIZ1,PIASX,PIASX-ALPHA,PIASX-BETA,SIZ2,ZMIZ4,miz )
Gene Full Name: protein inhibitor of activated STAT, 2
Band: 18q21.1
Quick LinksEntrez ID:9063; OMIM: 603567; Uniprot ID:PIAS2_HUMAN; ENSEMBL ID: ENSG00000078043; HGNC ID: 17311
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04630Jak-STAT signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200097Sumoylation by RanBP2 regulates transcriptional repression
200197IL12 signaling mediated by STAT4
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
P00038JAK/STAT signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2152Renal tubular acidosis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PIAS2 mRNAincreases expression 18648102
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of PIAS2 mRNAaffects expression 17331233
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PIAS2 mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PIAS2 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PIAS2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIAS2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIAS2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3115322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8714692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.223712494
MESH:D000236 Adenoma Diethylnitrosamine 7.2210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.6517620307 16434500 19052882 18056438 17162532 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.6516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.107296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1018506893 20101231 19539802 17162532 18210153 20512989 17055752 19418558 19335982 19822196 19208518 16698587 17173139 17428255 19052882 10737359 18788625 16830150 19701751 16935385 3581430 18665156 10672840 18785209 3084413 18978308 17761372 16502159 17978847 18971187 16288022 21159647 20007298 20084675 20514400 18691550 16878318 16681979 19171122 18056438 17138121 16807293 18393292 20727157 19919837 20524982 20214788 11831363 18494052 20432363 19394651 19107877 19383236 16779866 16328049 16540662 16569478 20935162 19519916
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 16120746 18670907
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.397505956
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.392727394 17174075 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 10.2919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 10.2916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.6419486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 8.6415861022 17681005 17110522 16919318 17333356 16105132 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2114531868 8156756 2524372 18759878 11298694 8970840 11906362 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.4320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4317107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.6311289319 9022650 18289764 7440962 6482804 8291058 18692083 18648102 9328219 6679447 1440618 9653073 16192314
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.6320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Diethylnitrosamine 8.8020387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.8015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3112621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.578697196 15340226 16354765 16959395 18606429
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Diethylnitrosamine 5.3818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3812878042 12200463
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8910783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 3.7115369732
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1816766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9820032147 19638242 18665156 18407596 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.7319426721 19256749 16942905 20501860 19833225 19551842 21278145 20405173 12771043 9163691 19254457 19850985 18644402 20434301 21047994 20492335 20137499 10737359 20452335 19642983 19638242 15175105 19427195 19090486 19499222 2422723 19690152 19294768 18754104 18977376 19812893 15885732 12112319 21167192 18648771 19255062 2862719 19073162 20583210 21071580 19996281 20118626 18978307 20101389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7316984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.87598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.872563599 19009564 19519916 18544905 17854601 19539802 18308698 3124819 9362446 16267830 18164116 18775883 18253720 18079962 19004024 18093689 18282651 19126423 16842330 17174075 21159647 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.8712151625
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.4417365036
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.336695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3311884234 19555203
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2816966607 16166281 18303189
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.053581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.059029167 3581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.3110923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11222880 11896295 11399792
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1317365031 17322281 17975199 15814490
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.936587162 7505956 1399818 6582329 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.937505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
KEGG:04630 Jak-STAT signaling pathway
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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