AutismKB 2.0

Annotation Detail for MAP3K6


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Basic Information Top
Gene Symbol:MAP3K6 ( ASK2,MAPKKK6,MEKK6,MGC125653,MGC20114 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 6
Band: 1p36.11
Quick LinksEntrez ID:9064; OMIM: 604468; Uniprot ID:M3K6_HUMAN; ENSEMBL ID: ENSG00000142733; HGNC ID: 6858
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
No data
Pathway IDPathway Name
P00021FGF signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MAP3K6 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MAP3K6 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of MAP3K6 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of MAP3K6 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of MAP3K6 mRNAincreases expression 19420014
C068073 Am 580 Am 580 results in decreased expression of MAP3K6 mRNAdecreases expression 16982809
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of MAP3K6 mRNA]decreases reaction|increases expression 17460151
D001151 Arsenic Arsenic results in decreased expression of MAP3K6 mRNAdecreases expression 19654921
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of MAP3K6 mRNAaffects expression 17331233
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MAP3K6 mRNAincreases expression 20504355
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MAP3K6 mRNAdecreases expression 15336504
D004041 Dietary Fats Dietary Fats results in decreased expression of MAP3K6 mRNAdecreases expression 18042831
D010126 Ozone anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of MAP3K6 mRNA]decreases reaction|increases expression 17460151
D010126 Ozone Ozone results in increased expression of MAP3K6 mRNAincreases expression 19555225
17095637
C041786 palm oil palm oil results in decreased expression of MAP3K6 mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of MAP3K6 mRNAincreases expression 12595580
C006253 pirinixic acid pirinixic acid results in increased expression of MAP3K6 mRNAincreases expression 18445702
C089730 rosiglitazone rosiglitazone results in decreased expression of MAP3K6 mRNAdecreases expression 16982809
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MAP3K6 mRNAincreases expression 17035482
D002762 Cholecalciferol Cholecalciferol results in decreased expression of MAP3K6 mRNAdecreases expression 16508948
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8114514962 11752688 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9720127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.636695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1817306315
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.7311874814
MESH:D000544 Alzheimer Disease Ozone 4.4515513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.4519621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8516251483 12569548 16835338 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 3.8515238619
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5515570426
MESH:D001249 Asthma Ozone 2.6217854713 16373670
MESH:D050197 Atherosclerosis Arsenic 3.2219371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.9916142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8120146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 1.8120435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8120435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6418417511 16777450 15516495 17626835 18315731 14754758 19059883
MESH:D002100 Cachexia Ozone 4.7016183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5715504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8216705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.823084413
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 8.8219418558
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.8216507464 17306315
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.6718922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6720419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0418640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.4217938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.2718022660 16973168
MESH:D002386 Cataract Acetaminophen 7.6010977129
MESH:D002386 Cataract Am 580 7.6017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.746135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis pirinixic acid 2.7919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 15340226 16354765 8697196 15668235
MESH:D003092 Colitis Am 580 4.9217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.7618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.7618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.2617446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.4612642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4617107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.8318551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.8321346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.8312392966 19739265 12594235 11287661 11743745 16177239 17562736 17906064 12958197 16781746 18713872 19416960 14550746 18071297 2444490 11461765 11834606 11421492 16485898 12705907 19420014 14725611 10663392 15968718 11739529 19085960 12153990 10915739 10774834 17522070 19370779 16081117 16393943 14986274 16227642 16109766 19164858 19923254 12540782 11529661 15619225
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4218367378
MESH:D004487 Edema pirinixic acid 11.2412083418
MESH:D004487 Edema rosiglitazone 11.2412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.2412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8715322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Dietary Fats 12.9718296743 17967931 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 12.9719236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 12.9719196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Dietary Fats 8.4918296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4920067830
MESH:D005534 Foot Diseases Arsenic 5.536392382
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005911 Gliosis Paraquat 5.1411124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.1316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.028697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.7616870215
MESH:D006930 Hyperalgesia rosiglitazone 7.7612083418
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4217050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.5721332399
MESH:D006973 Hypertension Arsenic 5.1716076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.5316093927
MESH:D007248 Infertility, Male Paraquat 3.224850670
MESH:D007249 Inflammation Dietary Fats 8.2520412841
MESH:D007249 Inflammation rosiglitazone 8.2512083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2512878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 12.2411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 12.2416306350
MESH:D007333 Insulin Resistance rosiglitazone 12.2416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007642 Keratosis Arsenic 4.9516930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.1712587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.2416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.2416705839
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 5.3416972261
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5217339181
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8518296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.4615980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 4.0319784758 16611625 19460945 16610002 19014921 11587558 12969438 12587719
MESH:D008107 Liver Diseases Arsenic 4.0311134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.067678174
MESH:D008113 Liver Neoplasms Arsenic 14.0616368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.0620195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 14.0620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.0616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.642876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6412151625
MESH:D008171 Lung Diseases Ozone 3.3519066396 8266340
MESH:D055370 Lung Injury Asbestos, Crocidolite 9.1117365036
MESH:D055370 Lung Injury Ozone 9.1120417186
MESH:D008175 Lung Neoplasms Arsenic 4.8217976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8217053015 20135361 20869020 18816296 18520028 20464547 20064080 18569708 6695378
MESH:D008175 Lung Neoplasms Ozone 4.828597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8219555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.3616827153
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1716966607 16166281 18303189
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.3417261469
MESH:D008679 Metaplasia Ozone 5.0810496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Arsenic 8.8815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.2318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.2318551238 7678174
MESH:D009369 Neoplasms Benzo(a)pyrene 4.7511141357
MESH:D009369 Neoplasms pirinixic acid 4.7517405874
MESH:D009410 Nerve Degeneration Paraquat 3.6816893418
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009436 Neural Tube Defects Arsenic 3.4216620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.3317056641
MESH:D009765 Obesity Dietary Fats 4.4019632207 17217161 16723640 21332399 18457598 11836018 18674790 20132043 20518802
MESH:D009765 Obesity pirinixic acid 4.4020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.7516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.7516049721
MESH:D010051 Ovarian Neoplasms Arsenic 2.7317306315
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010300 Parkinson Disease Paraquat 2.8011445065 11181820 15451049 16140633 12911755 15824117 11124998 16510128
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.3916190885
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9516905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 4.0916369182
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.8510923243
MESH:D011014 Pneumonia Ozone 10.9518007984 18929643 18381685
MESH:D011014 Pneumonia Paraquat 10.9512504350
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611399792 11118676 11896295 11222880
MESH:D011471 Prostatic Neoplasms Arsenic 2.7316140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7317292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.7317024972
MESH:D011507 Proteinuria Arsenic 3.9621343184
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.8517322281 17365031 15814490 17975199
MESH:D011658 Pulmonary Fibrosis Paraquat 5.8517997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.8611700416
MESH:D012135 Respiratory Sounds Paraquat 4.0211874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration Paraquat 3.8316458197
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7718551238
MESH:D012871 Skin Diseases Arsenic 2.7419834688 17548696 15952646 16702368 16759981 6392382 17453740 17050553 18709164 17938729 16353154
MESH:D012878 Skin Neoplasms Arsenic 13.4017029826 17050553 17976673 15504454 19538983 16251483
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.4019755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.408532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.4016192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.7916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.7916049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.7919322015 17306315 11144890 15987713 17976673 18640142 19429237
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.7917053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.8710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.8710091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014652 Vascular Diseases Arsenic 4.7017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D015430 Weight Gain Dietary Fats 3.7016723640
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30602
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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