AutismKB 2.0

Annotation Detail for CLDN12


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Basic Information Top
Gene Symbol:CLDN12 ( - )
Gene Full Name: claudin 12
Band: 7q21.13
Quick LinksEntrez ID:9069; OMIM: 611232; Uniprot ID:CLD12_HUMAN; ENSEMBL ID: ENSG00000157224; HGNC ID: 2034
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Cell junction organization
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CLDN12 mRNAaffects expression 17562736
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 5.2610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8610977129
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6919923254 12705907 16393943 18713872 11743745 18071297 12540782 11461765 10774834 19416960 14550746 16781746 11529661 14725611 17562736 10663392 19370779 12958197 16485898 11421492 12392966 17522070 12153990 16109766 11739529 11834606 14986274 17906064 16081117 19420014 19085960 2444490 12594235 19164858 19739265 15619225 15968718 10915739 16227642 11287661 16177239
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 5.5119426721
MESH:D005756 Gastritis Acetaminophen 5.0916983495
MESH:D006930 Hyperalgesia Acetaminophen 3.1516870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4715629191 12587719
MESH:D008107 Liver Diseases Acetaminophen 1.7216610002 19784758 11587558 16611625 19460945 12969438 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.8117185352 16871587
MESH:D008546 Melanoma, Experimental Acetaminophen 4.4719513568
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.3618514411
MESH:D010146 Pain Acetaminophen 2.8716870215
MESH:D014581 Urticaria Acetaminophen 3.6710982225
Pathway ID Pathway Name
REACT:20676 Cell junction organization
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018