AutismKB 2.0

Annotation Detail for CLDN8


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Basic Information Top
Gene Symbol:CLDN8 ( - )
Gene Full Name: claudin 8
Band: 21q22.11
Quick LinksEntrez ID:9073; OMIM: 611231; Uniprot ID:CLD8_HUMAN; ENSEMBL ID: ENSG00000156284; HGNC ID: 2050
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
hsa04530Tight junction
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014949 acetylhydrazine acetylhydrazine results in decreased expression of CLDN8 mRNAdecreases expression 15282401
D001374 Azacitidine Azacitidine results in increased expression of CLDN8 mRNAincreases expression 18661270
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in increased expression of CLDN8 mRNAincreases expression 18661270
D006861 Hydrogen Peroxide Hydrogen Peroxide affects the expression of CLDN8 mRNAaffects expression 18661270
C012589 trichostatin A trichostatin A results in increased expression of CLDN8 mRNAincreases expression 18661270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.7516936243
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 6.2519294695
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 7.1720641076
MESH:D005909 Glioblastoma trichostatin A 4.0518801729
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 5.4920641076
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.6516518626
MESH:D007938 Leukemia Azacitidine 3.8419148494
MESH:D007951 Leukemia, Myeloid Azacitidine 4.9919077051
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.6718720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 4.6718206229
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.6019299654
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 3.2111682029
MESH:D008175 Lung Neoplasms Azacitidine 2.7321224363
MESH:D008545 Melanoma trichostatin A 2.8016505122
MESH:D009006 Monosomy Azacitidine 6.6919299654
MESH:D009101 Multiple Myeloma Azacitidine 8.7219549372 18443271
MESH:D009101 Multiple Myeloma trichostatin A 8.7218172295
MESH:D009190 Myelodysplastic Syndromes Azacitidine 4.1817611569 19805378 18720364 17596541
MESH:D010051 Ovarian Neoplasms trichostatin A 3.2619331143
MESH:D010190 Pancreatic Neoplasms trichostatin A 3.3919294695
MESH:D010212 Papilloma Hydrogen Peroxide 4.5712065085
MESH:D055728 Primary Myelofibrosis trichostatin A 5.7417616702
MESH:D011471 Prostatic Neoplasms Azacitidine 3.8118324645
MESH:D011471 Prostatic Neoplasms trichostatin A 3.8119789329 18798265
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 3.2112065085
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
KEGG:05160 Hepatitis C
KEGG:04670 Leukocyte transendothelial migration
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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