AutismKB 2.0

Annotation Detail for CLDN6


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Basic Information Top
Gene Symbol:CLDN6 ( - )
Gene Full Name: claudin 6
Band: 16p13.3
Quick LinksEntrez ID:9074; OMIM: NA; Uniprot ID:CLD6_HUMAN; ENSEMBL ID: ENSG00000184697; HGNC ID: 2048
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
hsa04530Tight junction
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001374 Azacitidine Azacitidine results in decreased methylation of CLDN6 promoterdecreases methylation 18661270
D001374 Azacitidine Azacitidine results in increased expression of CLDN6 mRNAincreases expression 18661270
D001374 Azacitidine [trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN6 promoteraffects cotreatment|decreases methylation 18661270
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN6 mRNA]decreases expression|decreases reaction 18661270
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in decreased methylation of CLDN6 promoterdecreases methylation 18661270
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in increased expression of CLDN6 mRNAincreases expression 18661270
D005031 Ethylenethiourea Ethylenethiourea results in decreased expression of CLDN6 mRNAdecreases expression 18801409
D006861 Hydrogen Peroxide Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN6 mRNA]decreases expression|decreases reaction 18661270
D006861 Hydrogen Peroxide Hydrogen Peroxide affects the expression of CLDN6 mRNAaffects expression 18661270
C494474 perchlorate perchlorate results in decreased expression of CLDN6 mRNAdecreases expression 18801409
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CLDN6 mRNAincreases expression 20106945
D014212 Tretinoin Tretinoin results in increased expression of CLDN6 mRNAincreases expression 16236135
C012589 trichostatin A [trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN6 promoteraffects cotreatment|decreases methylation 18661270
C012589 trichostatin A trichostatin A results in decreased methylation of CLDN6 promoterdecreases methylation 18661270
C012589 trichostatin A trichostatin A results in increased expression of CLDN6 mRNAincreases expression 18661270
D014415 Tunicamycin Tunicamycin results in increased expression of CLDN6 mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 11752688 14514962
MESH:D000230 Adenocarcinoma Ethylenethiourea 3.937955072
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.901917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4718670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.6516936243
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0215668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 6.029407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.509664655 16925845 9224671 10589399 14991402 17551590 9142499 9125849 9211117 8800419
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.0315322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 13.0318230668
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.9619294695
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.8820641076
MESH:D016889 Endometrial Neoplasms Ethylenethiourea 8.507955072
MESH:D016889 Endometrial Neoplasms Tretinoin 8.5016569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2110568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.3411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.349664655 16938888
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5020067830
MESH:D005355 Fibrosis Tretinoin 9.5017994277
MESH:D005909 Glioblastoma Tretinoin 7.8417312396
MESH:D005909 Glioblastoma trichostatin A 7.8418801729
MESH:D006042 Goiter perchlorate 5.5318801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 5.3520641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.869664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.6316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.6315992940 17551590
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.4816518626
MESH:D007938 Leukemia Azacitidine 6.9619148494
MESH:D007938 Leukemia Tretinoin 6.9617143497
MESH:D007951 Leukemia, Myeloid Azacitidine 10.4919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 10.4916932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 6.5318720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.5319850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.5318206229
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.4119299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2816766008 17339181 17368321 19035177 16140955 19642359 17712046 16823087 15748426 17294898 17217047 16788101 12679006 17649720 9834237 17107899 17506722 19225113 16331271 19029980 16891316 16935935 19075265 17301526 17361223
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 3.7611682029
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.7612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.7618397230 16248980
MESH:D008113 Liver Neoplasms Ethylenethiourea 5.2511940454
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 5.2516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2212151625
MESH:D008175 Lung Neoplasms Azacitidine 2.6621224363
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.6611884234 19555203
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 3.7116752155
MESH:D008545 Melanoma trichostatin A 3.7116505122
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D009006 Monosomy Azacitidine 6.4019299654
MESH:D009101 Multiple Myeloma Azacitidine 8.3718443271 19549372
MESH:D009101 Multiple Myeloma trichostatin A 8.3718172295
MESH:D009190 Myelodysplastic Syndromes Azacitidine 8.0718720364 19805378 17596541 17611569
MESH:D009190 Myelodysplastic Syndromes Tretinoin 8.0717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009369 Neoplasms Tretinoin 2.4916594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3214600291
MESH:D009421 Nervous System Malformations Tretinoin 10.329125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D010051 Ovarian Neoplasms Tretinoin 5.3416936753
MESH:D010051 Ovarian Neoplasms trichostatin A 5.3419331143
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.7815976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.7819294695
MESH:D010212 Papilloma Hydrogen Peroxide 4.3412065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11118676 11222880 11399792
MESH:D055728 Primary Myelofibrosis trichostatin A 5.5117616702
MESH:D011471 Prostatic Neoplasms Azacitidine 3.8418324645
MESH:D011471 Prostatic Neoplasms trichostatin A 3.8418798265 19789329
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216116481 16283617
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.9912065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.9916192470
MESH:D012878 Skin Neoplasms Tretinoin 9.9916467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Ethylenethiourea 8.3211940454
MESH:D013964 Thyroid Neoplasms Tretinoin 8.3216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
KEGG:05160 Hepatitis C
KEGG:04670 Leukocyte transendothelial migration
KEGG:04530 Tight junction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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