AutismKB 2.0

Annotation Detail for CLDN9


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Basic Information Top
Gene Symbol:CLDN9 ( - )
Gene Full Name: claudin 9
Band: 16p13.3
Quick LinksEntrez ID:9080; OMIM: NA; Uniprot ID:CLD9_HUMAN; ENSEMBL ID: ENSG00000213937; HGNC ID: 2051
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa05160Hepatitis C
hsa04530Tight junction
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Cell junction organization
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in decreased expression of CLDN9 mRNAdecreases expression 20458559
D001374 Azacitidine Azacitidine results in decreased methylation of CLDN9 promoterdecreases methylation 18661270
D001374 Azacitidine Azacitidine results in increased expression of CLDN9 mRNAincreases expression 18661270
D001374 Azacitidine [trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN9 promoteraffects cotreatment|decreases methylation 18661270
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN9 mRNA]decreases expression|decreases reaction 18661270
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in decreased methylation of CLDN9 promoterdecreases methylation 18661270
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in increased expression of CLDN9 mRNAincreases expression 18661270
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of CLDN9 mRNAdecreases expression 17557909
D006861 Hydrogen Peroxide Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN9 mRNA]decreases expression|decreases reaction 18661270
D006861 Hydrogen Peroxide Hydrogen Peroxide affects the expression of CLDN9 mRNAaffects expression 18661270
C012589 trichostatin A [trichostatin A co-treated with Azacitidine] results in decreased methylation of CLDN9 promoteraffects cotreatment|decreases methylation 18661270
C012589 trichostatin A trichostatin A results in decreased methylation of CLDN9 promoterdecreases methylation 18661270
C012589 trichostatin A trichostatin A results in increased expression of CLDN9 mRNAincreases expression 18661270
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5019825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5014692618
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.0016206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9711135700 16217749 15073043 14691202 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.7216936243
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1017333356 17681005 11677210 16105132 17110522 16919318 15861022
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.8720501625
MESH:D015179 Colorectal Neoplasms Azacitidine 2.8719934284
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 6.1619294695
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 7.0820641076
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3712903497
MESH:D005234 Fatty Liver arsenic trioxide 8.8415073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.8415345470
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D005909 Glioblastoma trichostatin A 4.0218801729
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 5.4520641076
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.6016518626
MESH:D007938 Leukemia arsenic trioxide 7.1415070760
MESH:D007938 Leukemia Azacitidine 7.1419148494
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 10.9219077051
MESH:D007951 Leukemia, Myeloid Azacitidine 10.9219077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.6217050201 16968895 19850784 16467208 20471514
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 6.6218720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.6218206229
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.5419299654
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4117107899 12679006 19035177 19075265 16112521 17649720 16330433 17869043 11468182 17712046 19642359 15622746 11161223 16823087 16331271 9834237 15748426 15213294 16966277 12712474 19225113 16891316 17217047 15336539 12018890
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 3.2111682029
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4314682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.9119825857 11798837
MESH:D008175 Lung Neoplasms Azacitidine 2.9121224363
MESH:D008545 Melanoma trichostatin A 2.8016505122
MESH:D009006 Monosomy Azacitidine 6.6019299654
MESH:D009101 Multiple Myeloma arsenic trioxide 13.6219417148 14977855 15949261 11468182 19549372
MESH:D009101 Multiple Myeloma Azacitidine 13.6218443271 19549372
MESH:D009101 Multiple Myeloma trichostatin A 13.6218172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 8.2716105982 16882451
MESH:D009190 Myelodysplastic Syndromes Azacitidine 8.2717596541 17611569 18720364 19805378
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3110525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.4516624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms trichostatin A 5.4519331143
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.9015580305
MESH:D010190 Pancreatic Neoplasms trichostatin A 5.9019294695
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010212 Papilloma Hydrogen Peroxide 4.5012065085
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D055728 Primary Myelofibrosis trichostatin A 5.6717616702
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7519131511
MESH:D011471 Prostatic Neoplasms Azacitidine 2.7518324645
MESH:D011471 Prostatic Neoplasms trichostatin A 2.7518798265 19789329
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 3.2012065085
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.4215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5812845720 20435036 12973940 11780464
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
KEGG:05160 Hepatitis C
KEGG:04670 Leukocyte transendothelial migration
KEGG:04530 Tight junction
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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