AutismKB 2.0

Annotation Detail for EIF1AY


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Basic Information Top
Gene Symbol:EIF1AY ( - )
Gene Full Name: eukaryotic translation initiation factor 1A, Y-linked
Band: Yq11.223
Quick LinksEntrez ID:9086; OMIM: 400014; Uniprot ID:IF1AY_HUMAN; ENSEMBL ID: ENSG00000198692; HGNC ID: 3252
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of EIF1AY mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of EIF1AY mRNAincreases expression 16631469
C006632 arsenic trioxide arsenic trioxide results in increased expression of EIF1AY mRNAincreases expression 20458559
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of EIF1AY mRNAaffects expression 17555576
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of EIF1AY mRNAaffects cotreatment|increases expression 17183730
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of EIF1AY mRNAincreases expression 20713471
D012643 Selenium Selenium results in increased expression of EIF1AY mRNAincreases expression 18583539
D013629 Tamoxifen Tamoxifen affects the expression of EIF1AY mRNAaffects expression 17555576
C024746 tobacco tar tobacco tar results in decreased expression of EIF1AY mRNAdecreases expression 19559774
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of EIF1AY mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.728875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1019490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4119825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D000236 Adenoma Methylcholanthrene 3.596695378 10545420
MESH:D000550 Amblyopia Valproic Acid 5.5017688650
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7117497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5511922910
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8618775368 18985861 16609825 18940202 18177632 18558336 17688650 20603192 19232924 15238991 19460635 18396377 17157402 18316065 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 3.1520046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.8416206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.518888407
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3717474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.3716273361 16202921 19103187 17893378 19200415 19115204 17261762 19084267 21152245 16873071 19244106 21138602 20390343 19410462 20005174 19189210 18984771 19142967 19059307 18815881 17049068 11161223 20859285 18855134 19487384 18351453 19288272 19221464 17440819 20135344 19066611 19189212 18425577 19011961 17242785 20544844 16818667 15565566 19155303 15668708 20065188 18629630 19289846 18997820 18821012
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002277 Carcinoma Methylcholanthrene 4.1010545420
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.673084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6715553829 11135700 14691202 15073043 16217749
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.6716924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.7516192471
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.7519559774
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7620734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017681005 11677210 16105132 17333356 16919318 15861022 17110522
MESH:D003092 Colitis Selenium 3.9917936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7510525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7516575769 17688650 8888407
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4914550746 10915739 11739529 16781746 12594235 16081117 17562736 14725611 10663392 11287661 19164858 11461765 18713872 16109766 19370779 16177239 11743745 15968718 11529661 18071297 16393943 12958197 12392966 19416960 19923254 12705907 12540782 17906064 2444490 19739265 12153990 19085960 16485898 15619225 11834606 10774834 17522070 14986274 11421492 16227642 19420014
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4915131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.4919641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004421 Dystonia Valproic Acid 4.231851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1517893378 19155303 16202921 20544844
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.183922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0120417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.746254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.303659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005234 Fatty Liver arsenic trioxide 20.2715073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2715345470
MESH:D005234 Fatty Liver Tamoxifen 20.2719224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 20.2714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005315 Fetal Diseases Valproic Acid 5.1516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.3318558336 8888407
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1814633661 10962813
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006849 Hydrocephalus Valproic Acid 5.1017688650
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.8416612254
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tamoxifen 2.4319457130
MESH:D007251 Influenza, Human Selenium 4.4616624496
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1918625569
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0016467208 19850784 16968895 20471514 17050201
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.0017596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.329834237 11161223 17869043 12018890 17107899 16330433 16112521 16966277 16823087 19225113 17649720 16331271 12712474 15748426 19075265 15336539 17712046 12679006 15213294 17217047 16891316 11468182 15622746 19035177 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D008064 Lipidoses Tamoxifen 3.2717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7418564211
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 19784758 16610002 11587558 12969438 19460945 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.8114682389
MESH:D008113 Liver Neoplasms Tamoxifen 4.8116684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5720377131
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 6.57598648 1399818
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.5317228818
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6311798837 19825857
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.6310545420 9230183 21163286 1399818 16337739 7750092 20970405 17909032 6695378 11893704 20512841 16271038 15390079
MESH:D008175 Lung Neoplasms Tamoxifen 3.6318625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4015318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.4019196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D008881 Migraine Disorders Valproic Acid 3.3118765137 18803445
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2214977855 19417148 15949261 11468182 19549372
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.208888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7216105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.7217596541
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19196722 19200415
MESH:D009436 Neural Tube Defects arsenic trioxide 7.6910525206
MESH:D009436 Neural Tube Defects Valproic Acid 7.6916359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4519769630 12452020 16624393
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0720603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2019131511
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.8112752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3619155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8516876388 3137016 11738929 14763951 17978042 11044598 15475178 1511512
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9119490988
MESH:D013226 Status Epilepticus Valproic Acid 4.8112833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.5017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.763119515
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3011780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.308653321 16712894 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.868888407
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
Pathway ID Pathway Name
KEGG:03013 RNA transport
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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