AutismKB 2.0

Annotation Detail for PKMYT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PKMYT1 ( DKFZp547K1610,FLJ20093,MYT1 )
Gene Full Name: protein kinase, membrane associated tyrosine/threonine 1
Band: 16p13.3
Quick LinksEntrez ID:9088; OMIM: 602474; Uniprot ID:PMYT1_HUMAN; ENSEMBL ID: ENSG00000127564; HGNC ID: 29650
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04110Cell cycle
hsa04114Oocyte meiosis
Pathway IDPathway Name
Cell Cycle, Mitotic
No data
No data
Pathway IDPathway Name
500991Cyclin A/B1 associated events during G2/M transition
500877Cyclin E associated events during G1/S transition
500379Polo-like kinase mediated events
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PKMYT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of PKMYT1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PKMYT1 mRNAdecreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PKMYT1 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PKMYT1 mRNAincreases expression 19150397
D010634 Phenobarbital Phenobarbital affects the expression of PKMYT1 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of PKMYT1 mRNAaffects expression 19136022
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in decreased expression of PKMYT1 mRNAaffects cotreatment|decreases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 5.139612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.5219825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5220464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.8216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8219483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0117474063 20146248
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5911589617
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.823084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.8211135700 15073043 16217749 14691202 15553829
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.8220007298 17173139 20935162 6705139 1701930
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.2519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3512490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.186135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.1820889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3615213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9115619225 19739265 12153990 11287661 17562736 11461765 14550746 17906064 2444490 16177239 10774834 14986274 16485898 12705907 11529661 19416960 19370779 14725611 19923254 18713872 19420014 16227642 11421492 11834606 15968718 12958197 17522070 16109766 10663392 11743745 12594235 18071297 19164858 16081117 16393943 19085960 12392966 10915739 12540782 16781746 11739529
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Zidovudine 4.1815040536
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.5220426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.5212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.5216530937
MESH:D005234 Fatty Liver arsenic trioxide 14.6615073043
MESH:D005234 Fatty Liver pirinixic acid 14.6619236843 20131406
MESH:D005234 Fatty Liver Zidovudine 14.6618299183
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5416904648
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006402 Hematologic Diseases Zidovudine 4.9712579204
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5218467677 16221962 19176532 19772884
MESH:D015658 HIV Infections Zidovudine 3.6020032539 11363243 11141242 17358032 11698656
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.3416705839
MESH:D007680 Kidney Neoplasms Zidovudine 8.3412579204
MESH:D007938 Leukemia arsenic trioxide 2.9315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 10.6612560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 10.6620370541
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.6416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1717050201 16968895 16467208 19850784 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3616112521 16966277 19035177 17712046 17869043 15336539 19075265 17217047 17649720 16331271 9834237 15748426 12679006 19225113 16891316 17107899 15622746 16330433 16823087 11161223 11468182 12712474 15213294 12018890 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.6316882451
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1016611625 16610002 11587558 12969438 19784758 12587719 19014921 19460945
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 15.097678174
MESH:D008113 Liver Neoplasms arsenic trioxide 15.0914682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.0921137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 15.0919482888 15975961 19812893 19073162 8742319 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 15.0920007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.716135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.7120377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.712563599 1399818 6150874 17172636 18308698
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 3.6519825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6517053015 20135361 18520028 18816296 20869020 6695378 20064080 20464547 18569708
MESH:D008175 Lung Neoplasms Zidovudine 3.6518800350
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.2117358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2719417148 11468182 15949261 19549372 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.0518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2616882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2416624393
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4716624393 12452020 19769630
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.5415580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5416965848
MESH:D010235 Paraganglioma arsenic trioxide 4.4219927285
MESH:D011230 Precancerous Conditions Phenobarbital 3.842563599
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.1219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1217292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4518551238
MESH:D012640 Seizures Phenobarbital 6.454039156 11442880 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4619755658 10029692
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5417007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5420155912 2093021
MESH:D013274 Stomach Neoplasms Zidovudine 3.5417696246
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.8319014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.831399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.3015213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.7716049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.7712973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7717053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014625 Vaginal Neoplasms Zidovudine 5.0612579204
Pathway ID Pathway Name
KEGG:04110 Cell cycle
REACT:152 Cell Cycle, Mitotic
KEGG:04114 Oocyte meiosis
KEGG:04914 Progesterone-mediated oocyte maturation
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved