AutismKB 2.0

Annotation Detail for DNAJA3


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Basic Information Top
Gene Symbol:DNAJA3 ( FLJ45758,TID1,hTid-1 )
Gene Full Name: DnaJ (Hsp40) homolog, subfamily A, member 3
Band: 16p13.3
Quick LinksEntrez ID:9093; OMIM: 608382; Uniprot ID:DNJA3_HUMAN; ENSEMBL ID: ENSG00000103423; HGNC ID: 11808
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200128Neurotrophic factor-mediated Trk receptor signaling
No data
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Related Diseases/Disorders Top
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Desease IDDesease Name
1860Brain tumor
1944Breast cancer
2237Neoplasm metastasis
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DNAJA3 mRNAdecreases expression 19150397
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of DNAJA3 mRNAaffects cotreatment|decreases expression 18313992
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of DNAJA3 mRNAaffects cotreatment|decreases expression 17942748
D005485 Flutamide Flutamide results in increased expression of DNAJA3 mRNAincreases expression 17702527
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of DNAJA3 mRNAaffects cotreatment|increases expression 17183730
C006253 pirinixic acid pirinixic acid results in increased expression of DNAJA3 mRNAincreases expression 18301758
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of DNAJA3 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of DNAJA3 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of DNAJA3 mRNAincreases expression 16014739
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of DNAJA3 mRNAaffects cotreatment|decreases expression 17942748
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of DNAJA3 mRNAaffects cotreatment|increases expression 17183730
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of DNAJA3 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of DNAJA3 mRNAdecreases expression 19244175
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of DNAJA3 mRNAaffects cotreatment|decreases expression 18313992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8315322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.838875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.969612607
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.0817306315 16712894
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.6617497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001321 Autistic Disorder Valproic Acid 2.0019460635 15238991 18177632 18316065 16609825 20603192 17157402 17507914 18775368 18940202 19232924 18985861 17688650 18558336 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1317594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.2515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.258888407
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 1.9916507464 15276417 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4118572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.9720889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.9719524636 20056578
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0111677210 16105132 17110522 16919318 17333356 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 8.0119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 12621046 8697196 15668235 15340226
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.8317688650 8888407 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8319769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Selenium 6.4015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.401733752 19641884
MESH:D004362 Drug Toxicity Lamivudine 14.3615040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.3611462148
MESH:D004362 Drug Toxicity Zidovudine 14.3615040536
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:C538011 Eales disease Vitamin E 4.889068938
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.2917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.093922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9920417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.686426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.7415345470
MESH:D005234 Fatty Liver pirinixic acid 19.7420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 19.7419224547 14986274
MESH:D005234 Fatty Liver Zidovudine 19.7418299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.268888407 18558336
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.8316452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7516080930
MESH:D006333 Heart Failure pirinixic acid 7.1720558911
MESH:D006333 Heart Failure Selenium 7.1717162251
MESH:D006402 Hematologic Diseases Zidovudine 4.8312579204
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006509 Hepatitis B Lamivudine 5.2117703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2112044531 15274664 15309715 16476009 15631357
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19176532 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D015658 HIV Infections Lamivudine 7.2411141242 20032539 17530837 9296927
MESH:D015658 HIV Infections Zidovudine 7.2420032539 11363243 11698656 11141242 17358032
MESH:D006689 Hodgkin Disease sodium arsenite 3.2512676792
MESH:D019584 Hot Flashes Vitamin E 4.1514716179
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 18606429 15340226 16959395 16354765
MESH:D017588 Hyperandrogenism Flutamide 5.6315356085
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9418670907 18850075
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.7616612254
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.8817937319
MESH:D007248 Infertility, Male sodium arsenite 6.8812646999 15346721
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007251 Influenza, Human Selenium 11.5516624496
MESH:D007251 Influenza, Human Vitamin E 11.5516624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases sodium arsenite 6.3920008137
MESH:D007674 Kidney Diseases Vitamin E 6.3912488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9916518626
MESH:D007680 Kidney Neoplasms Zidovudine 3.8812579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5220370541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4716169303
MESH:D008113 Liver Neoplasms pirinixic acid 7.5816377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 7.5815276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008171 Lung Diseases sodium arsenite 7.6819095001
MESH:D008171 Lung Diseases Vitamin E 7.6816863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms sodium arsenite 4.9717306315 15276417 19931552 16712894 17077188
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9711884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.9711062179
MESH:D008175 Lung Neoplasms Zidovudine 4.9718800350
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8315318939
MESH:D008545 Melanoma sodium arsenite 2.0416487513 19082730
MESH:D008654 Mesothelioma Selenium 2.8315107826
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.0117358032
MESH:D008881 Migraine Disorders Valproic Acid 3.2718803445 18765137
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms pirinixic acid 5.1117405874
MESH:D009369 Neoplasms sodium arsenite 5.1111559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8020056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects sodium arsenite 7.5712854658
MESH:D009436 Neural Tube Defects Valproic Acid 7.578888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4615276417 17306315
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D011085 Polycystic Ovary Syndrome Flutamide 5.1115356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9811222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.9820603192
MESH:D011471 Prostatic Neoplasms Flutamide 2.733169114
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7316039940
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7315084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.7111422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.699296927
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0819110320 15737665
MESH:D012640 Seizures Valproic Acid 2.8116876388 3137016 15475178 11044598 11738929 1511512 17978042 14763951
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms sodium arsenite 5.7519524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D016135 Spinal Dysraphism sodium arsenite 9.8312854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.8319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D020521 Stroke Vitamin E 3.6116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5411723127 17306315 16452187 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.8711813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9012579204
MESH:D014652 Vascular Diseases sodium arsenite 4.5817056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6515869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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