AutismKB 2.0

Annotation Detail for UNC119


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Basic Information Top
Gene Symbol:UNC119 ( HRG4,POC7,POC7A )
Gene Full Name: unc-119 homolog (C. elegans)
Band: 17q11.2
Quick LinksEntrez ID:9094; OMIM: 604011; Uniprot ID:U119A_HUMAN; ENSEMBL ID: ENSG00000109103; HGNC ID: 12565
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2120Rabies
No data
No data
Desease Name
Cone-rod dystrophy
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of UNC119 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of UNC119 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of UNC119 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UNC119 mRNAaffects expression 16483693
D004041 Dietary Fats Dietary Fats results in decreased expression of UNC119 mRNAdecreases expression 18042831
D005419 Flavonoids Flavonoids results in decreased expression of UNC119 mRNAdecreases expression 18035473
C041786 palm oil palm oil results in decreased expression of UNC119 mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of UNC119 mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of UNC119 mRNAdecreases expression 18796159
19465110
D015032 Zinc Zinc affects the expression of UNC119 mRNAaffects expression 16979875
D015032 Zinc Zinc results in increased expression of UNC119 mRNAincreases expression 15226459
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of UNC119 mRNAincreases expression 15226459
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 11.2818287403
MESH:D000138 Acidosis Zinc Sulfate 11.287265320
MESH:D000169 Acrodermatitis Zinc 5.6017190629 17202136 16889938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000544 Alzheimer Disease Zinc 2.7816410023 16325427 17119284 16580781
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000755 Anemia, Sickle Cell Zinc 5.0616916123
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D000860 Anoxia Zinc Sulfate 5.217265320
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001249 Asthma Zinc 2.9917085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001930 Brain Injuries Zinc 4.8617109824
MESH:D001943 Breast Neoplasms Dietary Fats 1.9720435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6216705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.623581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.623084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.9316543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Zinc 3.7516936243
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.976135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.977505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.199022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.1919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1516354765 15668235 8697196 12621046 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7115322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Zinc 2.7119302082
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.978156756 14531868 18759878 11906362 12868966 2524372 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.642952479 3621924
MESH:D003920 Diabetes Mellitus Zinc 4.3316479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.258291058 6679447 18648102 1440618 18692083 16192314 9653073 9022650 18289764 11289319 7440962 6482804 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2517562736 14986274 10774834 19739265 16393943 11287661 11421492 10663392 19420014 16177239 19923254 19416960 12594235 12958197 19164858 11743745 19370779 11461765 12392966 14550746 17522070 16781746 15619225 11834606 16485898 14725611 2444490 16109766 12540782 11529661 18713872 17906064 18071297 11739529 16081117 12153990 15968718 19085960 10915739 16227642 12705907
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.783581430
MESH:D004938 Esophageal Neoplasms Zinc 4.7816543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Dietary Fats 8.1718296743 19551842 19004024 17967931
MESH:D005234 Fatty Liver pirinixic acid 8.1720131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Dietary Fats 9.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2220067830
MESH:D005756 Gastritis Acetaminophen 11.9116983495
MESH:D005756 Gastritis Zinc 11.9117241300
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006130 Growth Disorders Zinc 4.0517217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006333 Heart Failure pirinixic acid 7.4220558911
MESH:D006333 Heart Failure Zinc 7.4217162251
MESH:D006335 Heart Injuries Zinc 5.9917074742
MESH:D016481 Helicobacter Infections Zinc 4.6817241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006527 Hepatolenticular Degeneration Zinc 11.9117276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 11.9117063115
MESH:D006529 Hepatomegaly pirinixic acid 8.8518467677 19176532 16221962 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8516120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2616959395 8697196 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D007022 Hypotension Zinc Sulfate 4.627265320
MESH:D007249 Inflammation Dietary Fats 8.7220412841
MESH:D007249 Inflammation Flavonoids 8.7217296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.7212878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.5411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007511 Ischemia Zinc 4.8116584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 6.4115629191 12587719
MESH:D007674 Kidney Diseases Zinc 6.4116960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.7516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.756582329
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.3815237267
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 16611625 16610002 19460945 19014921 12969438 11587558 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.607678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.6015890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.266135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.263712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.3812773700
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity Dietary Fats 4.5419632207 21332399 20132043 11836018 18674790 17217161 18457598 20518802 16723640
MESH:D009765 Obesity pirinixic acid 4.5420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.3316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.336482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011225 Pre-Eclampsia Zinc 4.2817114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms Zinc 3.8016517595 16700911 16606632 12429649
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 9.353692021
MESH:D012162 Retinal Degeneration Zinc 9.3516584753
MESH:D012174 Retinitis Pigmentosa marker/mechanism
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.997505956 6582329 3712494 6587162 1399818
MESH:D014062 Tongue Neoplasms Zinc 4.5316543248
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1716049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.178074119
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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