AutismKB 2.0

Annotation Detail for DHX57


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Basic Information Top
Gene Symbol:DHX57 ( DDX57,FLJ32861 )
Gene Full Name: DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
Band: 2p22.1
Quick LinksEntrez ID:90957; OMIM: NA; Uniprot ID:DHX57_HUMAN; ENSEMBL ID: ENSG00000163214; HGNC ID: 20086
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DHX57 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of DHX57 mRNAincreases expression 19774075
D007657 Ketone Bodies Ketone Bodies results in decreased expression of DHX57 mRNAdecreases expression 16807920
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DHX57 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2018057881 18218290 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.2019698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.5319483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 10.5319483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0019225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.7218974383
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1819416960 19085960 18713872 14986274 18071297 16109766 16781746 17906064 10663392 16227642 12705907 19420014 11461765 16081117 14725611 12958197 19370779 19739265 10774834 19164858 15619225 11287661 14550746 11834606 2444490 16177239 12540782 17522070 12153990 12594235 11529661 10915739 16393943 11421492 11739529 15968718 12392966 19923254 16485898 11743745 17562736
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.1815265979 18218290
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D005234 Fatty Liver Amiodarone 9.2514986274
MESH:D005234 Fatty Liver pirinixic acid 9.2519236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly Amiodarone 10.5115265979
MESH:D006529 Hepatomegaly pirinixic acid 10.5119176532 18467677 19772884 16221962
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.308137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D007037 Hypothyroidism Amiodarone 5.0818020914 17991464
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D008064 Lipidoses Amiodarone 3.7915342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.7011587558 19784758 19460945 12969438 12587719 19014921 16610002 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.9315890375 20007298 16377806
MESH:D008133 Long QT Syndrome Amiodarone 3.8911989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.6212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.2018516814
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009181 Mycoses Amiodarone 5.6212754197 17974566
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9711597910 12490602 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.7218724381
MESH:D013276 Stomach Ulcer Amiodarone 3.7418087811
MESH:D013610 Tachycardia Amiodarone 4.8011238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7019225199
MESH:D013959 Thyroid Diseases Amiodarone 5.4819731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.4218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.8211989578 17467628
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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