Annotation Detail for TBX18
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C010914 |
2,4-diaminotoluene |
2,4-diaminotoluene results in decreased expression of TBX18 mRNA | decreases expression | 20713471
|
| D006830 |
Hydralazine |
[Hydralazine co-treated with Valproic Acid] results in increased expression of TBX18 mRNA | affects cotreatment|increases expression | 17183730
|
| D008345 |
Manganese |
Manganese results in increased expression of TBX18 mRNA | increases expression | 17175027
|
| C025340 |
manganese chloride |
manganese chloride results in increased expression of TBX18 mRNA | increases expression | 17175027
|
| D014635 |
Valproic Acid |
[Hydralazine co-treated with Valproic Acid] results in increased expression of TBX18 mRNA | affects cotreatment|increases expression | 17183730
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000014 |
Abnormalities, Drug-Induced |
|
Valproic Acid |
4.02 | 8875741 |
| MESH:D000015 |
Abnormalities, Multiple |
|
Valproic Acid |
4.30 | 19490988 |
| MESH:D000550 |
Amblyopia |
|
Valproic Acid |
5.85 | 17688650 |
| MESH:D000756 |
Anemia, Sideroblastic |
|
Manganese |
12.30 | 16910769 |
| MESH:D000756 |
Anemia, Sideroblastic |
|
manganese chloride |
12.30 | 16910769 |
| MESH:D001008 |
Anxiety Disorders |
|
Valproic Acid |
3.86 | 17497229 |
| MESH:D001321 |
Autistic Disorder |
|
Valproic Acid |
1.98 | 20603192 17507914 18396377 18558336 16609825 17157402 19460635 17688650 18177632 18316065 18940202 15238991 18775368 18985861 19232924 |
| MESH:D001714 |
Bipolar Disorder |
|
Valproic Acid |
3.23 | 20046352 17594078 |
| MESH:D001848 |
Bone Diseases, Developmental |
|
Valproic Acid |
3.61 | 8888407 |
| MESH:D001943 |
Breast Neoplasms |
|
2,4-diaminotoluene |
3.13 | 11921183 |
| MESH:D002659 |
Child Development Disorders, Pervasive |
|
Valproic Acid |
2.81 | 20734317 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
Valproic Acid |
1.90 | 16575769 8888407 17688650 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Valproic Acid |
2.25 | 19641884 1733752 |
| MESH:D004421 |
Dystonia |
|
Valproic Acid |
4.45 | 1851702 |
| MESH:D004831 |
Epilepsies, Myoclonic |
|
Valproic Acid |
4.64 | 3659116 17275665 |
| MESH:D004828 |
Epilepsies, Partial |
|
Valproic Acid |
4.53 | 16628512 3922381 |
| MESH:D004827 |
Epilepsy |
|
Valproic Acid |
3.09 | 18234410 20417680 |
| MESH:D004832 |
Epilepsy, Absence |
|
Valproic Acid |
3.91 | 6426943 7562514 6254150 |
| MESH:D017029 |
Epilepsy, Complex Partial |
|
Valproic Acid |
4.78 | 7750514 |
| MESH:D004830 |
Epilepsy, Tonic-Clonic |
|
Valproic Acid |
4.60 | 3659116 |
| MESH:D005234 |
Fatty Liver |
|
Valproic Acid |
3.67 | 19224547 14986274 |
| MESH:D005315 |
Fetal Diseases |
|
Valproic Acid |
5.50 | 16575769 |
| MESH:D005317 |
Fetal Growth Retardation |
|
Valproic Acid |
4.57 | 18558336 8888407 |
| MESH:D005909 |
Glioblastoma |
|
Manganese |
4.13 | 17043766 |
| MESH:D006849 |
Hydrocephalus |
|
Valproic Acid |
5.41 | 17688650 |
| MESH:D046110 |
Hypertension, Pregnancy-Induced |
|
Hydralazine |
5.11 | 16612254 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
Valproic Acid |
2.19 | 16294345 17596541 |
| MESH:D017563 |
Lung Diseases, Interstitial |
|
Valproic Acid |
4.87 | 17228818 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
2,4-diaminotoluene |
3.78 | 11921183 |
| MESH:D020149 |
Manganese Poisoning |
|
Manganese |
6.13 | 19453300 16551646 16568477 |
| MESH:D008881 |
Migraine Disorders |
|
Valproic Acid |
3.44 | 18765137 18803445 |
| MESH:D009069 |
Movement Disorders |
|
Manganese |
5.41 | 16551646 |
| MESH:D009139 |
Musculoskeletal Abnormalities |
|
Valproic Acid |
4.40 | 8888407 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
Valproic Acid |
3.33 | 17596541 |
| MESH:D009410 |
Nerve Degeneration |
|
Manganese |
4.55 | 16551646 |
| MESH:D009436 |
Neural Tube Defects |
|
Valproic Acid |
3.34 | 16359493 8888407 |
| MESH:D010300 |
Parkinson Disease |
|
Manganese |
3.47 | 11181820 |
| MESH:D020734 |
Parkinsonian Disorders |
|
Manganese |
4.82 | 16140633 |
| MESH:D011297 |
Prenatal Exposure Delayed Effects |
|
Valproic Acid |
4.37 | 20603192 |
| MESH:D019310 |
Pseudolymphoma |
|
Valproic Acid |
5.15 | 12752131 11422049 |
| MESH:D012208 |
Rhabdomyosarcoma |
|
Valproic Acid |
4.58 | 19155313 |
| MESH:D012559 |
Schizophrenia |
|
Valproic Acid |
2.10 | 15737665 19110320 |
| MESH:D012640 |
Seizures |
|
Valproic Acid |
2.96 | 11044598 11738929 3137016 17978042 1511512 15475178 16876388 14763951 |
| MESH:D016135 |
Spinal Dysraphism |
|
Valproic Acid |
4.06 | 19490988 |
| MESH:D013226 |
Status Epilepticus |
|
Valproic Acid |
5.15 | 12833885 |
| MESH:D014178 |
Translocation, Genetic |
|
Valproic Acid |
5.85 | 17262798 |
| MESH:D020194 |
Unverricht-Lundborg Syndrome |
|
Valproic Acid |
5.06 | 3119515 |
| MESH:D014564 |
Urogenital Abnormalities |
|
Valproic Acid |
5.13 | 8888407 |
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