AutismKB 2.0

Annotation Detail for USP2


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Basic Information Top
Gene Symbol:USP2 ( UBP41,USP9 )
Gene Full Name: ubiquitin specific peptidase 2
Band: 11q23.3
Quick LinksEntrez ID:9099; OMIM: 604725; Uniprot ID:UBP2_HUMAN; ENSEMBL ID: ENSG00000036672; HGNC ID: 12618
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
Desease Name
insulin obesity
METABOLIC
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of USP2 mRNAdecreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of USP2 mRNAaffects expression 21346803
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of USP2 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen affects the expression of USP2 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of USP2 mRNAdecreases expression 18544908
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of USP2 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of USP2 mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of USP2 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of USP2 mRNAincreases expression 20106945
D002101 Cacodylic Acid Cacodylic Acid results in increased expression of USP2 mRNAincreases expression 17720352
D016572 Cyclosporine Cyclosporine results in decreased expression of USP2 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of USP2 mRNAdecreases expression 19638242
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of USP2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of USP2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of USP2 mRNAaffects cotreatment|decreases expression 17942748
C010176 halofuginone halofuginone results in decreased expression of USP2 mRNAdecreases expression 17180598
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of USP2 mRNAincreases expression 17616710
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of USP2 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of USP2 mRNAincreases expression 19482888
19270015
C006253 pirinixic acid pirinixic acid affects the expression of USP2 mRNAaffects expression 17950772
18445702
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of USP2 mRNAaffects binding|decreases expression|increases activity 19710929
C031280 pyrazole pyrazole results in decreased expression of USP2 mRNAdecreases expression 17945193
C009250 sevoflurane sevoflurane affects the expression of USP2 mRNAaffects expression 15967596
C017947 sodium arsenite sodium arsenite results in increased expression of USP2 mRNAincreases expression 17879257
D013629 Tamoxifen Tamoxifen affects the expression of USP2 mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of USP2 mRNAaffects expression 17440010
C517826 tetrabrominated diphenyl ether 47 tetrabrominated diphenyl ether 47 results in decreased expression of USP2 mRNAdecreases expression 20056577
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of USP2 mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of USP2 mRNAincreases expression 19465110
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of USP2 mRNAdecreases expression 19490992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4014745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.796195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7911752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0520127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0514692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.346695378
MESH:D000236 Adenoma Diethylnitrosamine 6.346695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.6117620307 16434500 19052882 19061943 17162532 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.6116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5515276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7516712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6720041841 18057881 18218290
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.7919698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.3618445737
MESH:D001321 Autistic Disorder tetrabrominated diphenyl ether 47 2.3619211157
MESH:D001778 Blood Coagulation Disorders Amiodarone 14.5119483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.5119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.5112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3017474063 20146248
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.3017474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.3017474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.3019189212 19155303 17893378 17049068 18815881 16202921 20544844 19066611 19084267 19142967 19115204 19103187 19200415 17440819 15565566 19244106 16873071 16818667 21152245 18855134 19189210 20135344 15668708 20065188 20859285 21138602 19011961 18629630 19221464 20005174 18351453 19289846 18821012 16273361 19288272 18984771 18997820 17242785 19059307 20390343 19487384 17261762 11161223 19410462 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3519066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.713084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.7121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.7120512989 19171122 18691550 19822196 16830150 19335982 19418558 20935162 19107877 11831363 19919837 21159647 16540662 16288022 19383236 17173139 18665156 16328049 16569478 18393292 18494052 18785209 16698587 17428255 18056438 20514400 20214788 20524982 20432363 19394651 10737359 3084413 16681979 19519916 20101231 16779866 18978308 20084675 18971187 17761372 16935385 19052882 19208518 17978847 17162532 20007298 18788625 16807293 18210153 18506893 16878318 19539802 16502159 3581430 19701751 20727157 17138121 10672840 17055752
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.716705139 17173139 20007298 1701930 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.7117306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.7116924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4520419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.4518572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 16120746 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8419225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9318974383
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.166135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.1612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.162727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.1619524636 20056578
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis Cyclosporine 12.6919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.6917333356 16919318 11677210 16105132 17110522 17681005 15861022
MESH:D002779 Cholestasis pirinixic acid 12.6919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0416354765 12621046 8697196 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8718551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2119031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3519279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 14.6821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.6812392966 14725611 12540782 17906064 11529661 11461765 16393943 19739265 11739529 10915739 19420014 18071297 11743745 19416960 15968718 10663392 12958197 12153990 14986274 16781746 10774834 12705907 16485898 11287661 16081117 18713872 17562736 17522070 19085960 11421492 15619225 19164858 12594235 14550746 16177239 19370779 2444490 16227642 19923254 16109766 11834606
MESH:D056486 Drug-Induced Liver Injury Amiodarone 14.6818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.6819107877
MESH:D056486 Drug-Induced Liver Injury pyrazole 14.6812499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.6820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:D004487 Edema pirinixic acid 6.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.4619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9517893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.7211558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4816530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.4815547721 16510608 15623463 15547733 15264214 15878914 16805852 16704527 15150132
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Amiodarone 28.9114986274
MESH:D005234 Fatty Liver Cyclosporine 28.9119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 28.9121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.9115345470
MESH:D005234 Fatty Liver pirinixic acid 28.9120131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 28.9119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0319069698
MESH:D005355 Fibrosis Cyclosporine 7.9812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9820067830
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5316452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1810048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006529 Hepatomegaly Amiodarone 19.4415265979
MESH:D006529 Hepatomegaly Phenobarbital 19.4416109766
MESH:D006529 Hepatomegaly pirinixic acid 19.4418467677 19176532 19772884 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.4416120746 12621046 15340226
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.6017440010
MESH:D006689 Hodgkin Disease sodium arsenite 3.0312676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8918606429 15340226 16354765 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.5816870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.739751232 8137927
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006965 Hyperplasia halofuginone 5.0911874485
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.3618020914 17991464
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.3117937319
MESH:D007248 Infertility, Male sodium arsenite 6.3112646999 15346721
MESH:D007249 Inflammation Diethylnitrosamine 7.8118785209
MESH:D007249 Inflammation Tamoxifen 7.8119457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.5015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.508314463 18776723 10903974
MESH:D007674 Kidney Diseases sodium arsenite 9.5020008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.6516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.6512371664
MESH:D007680 Kidney Neoplasms Tamoxifen 11.6518625569
MESH:D007859 Learning Disorders sevoflurane 4.6219212262
MESH:D008064 Lipidoses Amiodarone 7.5617567588 15342952
MESH:D008064 Lipidoses Tamoxifen 7.5615342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.7120032147 19638242 18665156 18522880 18407596
MESH:D008103 Liver Cirrhosis halofuginone 10.7117180598
MESH:D008103 Liver Cirrhosis Phenobarbital 10.7121047994
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 4.8312175628 14739098 16489207 11172339 18458672
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8312878042
MESH:D008107 Liver Diseases Acetaminophen 6.2512587719 19014921 16610002 16611625 19460945 12969438 11587558 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2517034775
MESH:D008107 Liver Diseases Phenobarbital 6.2519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 29.087678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 29.089163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.0820195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.0820501860 16942905 20583210 19638242 2862719 18644402 19996281 20452335 21167192 20137499 15885732 12771043 19254457 19294768 19255062 10737359 19551842 20405173 20434301 21047994 20101389 18754104 18648771 19073162 19642983 19690152 21071580 12112319 20118626 19256749 18977376 19833225 19850985 20492335 18978307 19090486 15175105 9163691 19427195 19426721 21278145 19499222 2422723 19812893
MESH:D008113 Liver Neoplasms Phenobarbital 29.088742319 15975961 19073162 19482888 21047994 19812893
MESH:D008113 Liver Neoplasms pirinixic acid 29.0820007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 29.0816712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 29.0816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.0816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.646135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.648603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.6418544905 2563599 18775883 18282651 18093689 17174075 19009564 19519916 16267830 9362446 18079962 21159647 19539802 16842330 18253720 17854601 18164116 18308698 17942915 19004024 19126423 3124819
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 17.641399818 17172636 18308698 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.6412151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4617391786 11989578 15350150
MESH:D008171 Lung Diseases Amiodarone 7.1812587719
MESH:D008171 Lung Diseases sodium arsenite 7.1819095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3318516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.3114755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.3120869020 18520028 18569708 18816296 20064080 20135361 6695378 20464547 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.3120512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms sodium arsenite 8.3117077188 15276417 16712894 17306315 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 8.3118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3119555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5311731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.4019453300
MESH:D008545 Melanoma sodium arsenite 3.2316487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.2312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008569 Memory Disorders sevoflurane 4.6019212262
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009181 Mycoses Amiodarone 4.7517974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7118551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.539029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7711141357
MESH:D009369 Neoplasms pirinixic acid 7.7717405874
MESH:D009369 Neoplasms sodium arsenite 7.7711559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5220056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8519196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1519348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0512854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3016049721
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.3915276417 17306315
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0816540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.0816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.5212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.522563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.522563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0411399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5817292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8011597910 12832656 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012640 Seizures 2,6-dinitrotoluene 5.5918551238
MESH:D012640 Seizures Phenobarbital 5.593137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9318724381
MESH:D012871 Skin Diseases halofuginone 3.4711874485
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.9919755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 8.9918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0616709447
MESH:D013088 Spermatocele Tamoxifen 11.0616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8919457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6812854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3220155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3218456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.3212958204 17575124
MESH:D013276 Stomach Ulcer Amiodarone 3.1818087811
MESH:D013610 Tachycardia Amiodarone 4.1411238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0419225199
MESH:D013733 Testicular Diseases pyrazole 4.666499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Amiodarone 11.5519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.5512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.807505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.801399818
MESH:D013971 Thyrotoxicosis Amiodarone 4.7118020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.0417467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.1916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.1917053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 15.1915537745
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 15.1916452187 11723127 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.1917572228 8653321 16712894
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4015869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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