AutismKB 2.0

Annotation Detail for KIFC2


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Basic Information Top
Gene Symbol:KIFC2 ( - )
Gene Full Name: kinesin family member C2
Band: 8q24.3
Quick LinksEntrez ID:90990; OMIM: NA; Uniprot ID:KIFC2_HUMAN; ENSEMBL ID: ENSG00000167702; HGNC ID: 29530
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KIFC2 mRNAaffects expression 17562736
C068073 Am 580 Am 580 results in decreased expression of KIFC2 mRNAdecreases expression 16982809
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of KIFC2 mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of KIFC2 mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in decreased expression of KIFC2 mRNAaffects cotreatment|decreases expression 16931933
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIFC2 mRNAaffects cotreatment|increases expression 17942748
D009151 Mustard Gas Mustard Gas results in increased expression of KIFC2 mRNAincreases expression 15674844
C089730 rosiglitazone rosiglitazone results in decreased expression of KIFC2 mRNAdecreases expression 16982809
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIFC2 mRNAaffects cotreatment|increases expression 17942748
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of KIFC2 mRNAdecreases expression 18087596
D014635 Valproic Acid Valproic Acid results in increased expression of KIFC2 mRNAincreases expression 19101580
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in decreased expression of KIFC2 mRNAaffects cotreatment|decreases expression 16931933
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8314514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 8.838875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0419490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.969612607
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.7015814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000544 Alzheimer Disease rosiglitazone 2.8719621015
MESH:D000550 Amblyopia Valproic Acid 5.4117688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.6617497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.2019898480
MESH:D001249 Asthma Mustard Gas 2.7410378619
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518985861 16609825 17507914 15238991 20603192 17688650 18316065 19232924 18558336 19460635 17157402 18775368 18177632 18940202 18396377
MESH:D001714 Bipolar Disorder Valproic Acid 3.1317594078 20046352
MESH:D001768 Blister Mustard Gas 5.3119167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.2515746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 8.258888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8820146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8820435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1517687719 10378619
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4611212258
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.0020419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 5.0011212258
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.8910977129
MESH:D002386 Cataract Am 580 7.8917460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6012371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7420734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0517681005 15861022 16919318 17110522 17333356 11677210 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 15340226 16354765 8697196 12621046
MESH:D003092 Colitis Am 580 5.1017035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.5017688650 16575769 8888407
MESH:D003920 Diabetes Mellitus rosiglitazone 4.4017446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.5812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3211461765 11529661 14986274 19420014 11421492 18713872 17522070 11739529 16781746 12540782 16485898 11743745 16393943 10663392 19739265 10774834 12958197 19164858 19370779 15619225 11287661 12153990 12705907 14550746 19085960 12392966 19416960 12594235 15968718 2444490 16081117 19923254 17562736 10915739 16177239 11834606 14725611 17906064 16227642 18071297 16109766
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3220420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.321733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Lamivudine 14.3615040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 14.3611462148
MESH:D004362 Drug Toxicity Zidovudine 14.3615040536
MESH:D004421 Dystonia Valproic Acid 4.171851702
MESH:D004487 Edema Mustard Gas 12.2311428647 9260866 11402378 11428631
MESH:D004487 Edema rosiglitazone 12.2312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.2312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.293659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.0916628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9918234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.686426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.447750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.223659116
MESH:D004890 Erythema Mustard Gas 5.319357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 25.9219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 25.9215345470
MESH:D005234 Fatty Liver rosiglitazone 25.9219196556
MESH:D005234 Fatty Liver Valproic Acid 25.9214986274 19224547
MESH:D005234 Fatty Liver Zidovudine 25.9218299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005315 Fetal Diseases Valproic Acid 5.0616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2618558336 8888407
MESH:D005355 Fibrosis Cyclosporine 8.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6310048152 11294989
MESH:D006402 Hematologic Diseases Zidovudine 4.8312579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006509 Hepatitis B Lamivudine 5.2117703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.2112044531 15631357 15274664 16476009 15309715
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0316120746 15340226 12621046
MESH:D015658 HIV Infections Lamivudine 7.2411141242 20032539 9296927 17530837
MESH:D015658 HIV Infections Zidovudine 7.2420032539 11363243 11698656 17358032 11141242
MESH:D006849 Hydrocephalus Valproic Acid 5.0217688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 8.1816870215
MESH:D006930 Hyperalgesia rosiglitazone 8.1812083418
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Mustard Gas 12.5117524151 11428647 8975870 11428631 9260866 16001271 11428620 11402378 9357497
MESH:D007249 Inflammation rosiglitazone 12.5112083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.5112878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 12.5118590791
MESH:D007333 Insulin Resistance rosiglitazone 3.8716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8812371664
MESH:D007680 Kidney Neoplasms Zidovudine 7.8812579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5220370541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1716294345 17596541
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 2.5917347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5912878042
MESH:D008107 Liver Diseases Acetaminophen 1.6512969438 16610002 19014921 11587558 19460945 12587719 19784758 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.4520195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008171 Lung Diseases Mustard Gas 3.5218702808 18161513
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4417228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7420464547 20869020 18816296 6695378 18569708 18520028 17053015 20135361 20064080
MESH:D008175 Lung Neoplasms Mustard Gas 6.748781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7411884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 6.7416288123 3440675 11091918 12111688
MESH:D008175 Lung Neoplasms Zidovudine 6.7418800350
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 3.4616827153
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.4717261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.0117358032
MESH:D008881 Migraine Disorders Valproic Acid 3.2718765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.0816381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.0815006635
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.148888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2117596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2211141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects Valproic Acid 3.2016359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009503 Neutropenia Mustard Gas 4.0916761898 7688884
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D011041 Poisoning Mustard Gas 3.9115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.9811896295 11222880 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.9820603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011537 Pruritus Ethinyl Estradiol 10.0516919318 15861022
MESH:D011537 Pruritus Mustard Gas 10.0518058305
MESH:D019310 Pseudolymphoma Valproic Acid 4.7112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9617894541 10334151 17266442 17620002 17720292
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.7618410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.699296927
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2919155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.811511512 16876388 11044598 15475178 3137016 17978042 14763951 11738929
MESH:D012871 Skin Diseases Mustard Gas 2.7415451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7910029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7916192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 9.7918590791
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7112833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.622093021 20155912
MESH:D013274 Stomach Neoplasms Zidovudine 2.6217696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D014178 Translocation, Genetic Valproic Acid 5.4117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.673119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.4917053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 5.4912846360
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.788888407
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9012579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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