AutismKB 2.0

Annotation Detail for CREB3L1


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Basic Information Top
Gene Symbol:CREB3L1 ( OASIS )
Gene Full Name: cAMP responsive element binding protein 3-like 1
Band: 11p11.2
Quick LinksEntrez ID:90993; OMIM: NA; Uniprot ID:CR3L1_HUMAN; ENSEMBL ID: ENSG00000157613; HGNC ID: 18856
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04962Vasopressin-regulated water reabsorption
hsa05016Huntington's disease
hsa05215Prostate cancer
No data
No data
Pathway IDPathway Name
P00055Transcription regulation by bZIP transcription factor
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CREB3L1 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of CREB3L1 mRNAaffects expression 17562736
C006780 bisphenol A bisphenol A results in increased expression of CREB3L1 mRNAincreases expression 20678512
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of CREB3L1 mRNAincreases expression 17484886
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of CREB3L1 mRNAincreases expression 16934159
C008493 methylselenic acid methylselenic acid results in decreased expression of CREB3L1 mRNAdecreases expression 18548127
D016226 Phosphorus, Dietary Phosphorus, Dietary affects the expression of CREB3L1 mRNAaffects expression 17651324
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CREB3L1 mRNAincreases expression 18691609
19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001862 Bone Resorption bisphenol A 4.1011985600
MESH:D001943 Breast Neoplasms bisphenol A 2.0317123778
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.0816097048 15673190 16011737 16227642 10355542 16192424 16124888 15700767 15721981 3786805 16050911 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.943084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9418788625
MESH:D002278 Carcinoma in Situ bisphenol A 5.3317123778
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 12621046 8697196 15340226 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.5114725611 18713872 16781746 19420014 12958197 11743745 12705907 12153990 17906064 12594235 15968718 12540782 17522070 10915739 11461765 19923254 18071297 14550746 19416960 11287661 11421492 15619225 12392966 19739265 16393943 10663392 19370779 11529661 16485898 19164858 16177239 2444490 16227642 11739529 11834606 10774834 16109766 16081117 19085960 14986274 17562736
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.516884620 10915739 6623471 15968718 3786805 19085960 16227642 2869522 11566570 16177239 9327722 4309450 3732212 21278145 7120509 7440962 7179309 17522070 10092053 19336974 15998439 15027814
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 9.5117851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2816714409 15322242 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4116045604 19224547 12631006 17595544 15959796 61145 12795759 16239168
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.8819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216959395 15340226 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 3.4416393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3215629191 12587719
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9216943688 11408273 17157831 17334410 16239168 17174718 21278145 16221502 11903743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3414716496 18277467 17823541 15931870 14620537 18210741 15057751 15730626 18006644 17708605 17698563 17557913 18166357 12632514 20821823 15338365 16015684 17631135 18481824 16192424 17944888 16248980 18054572 12898905 12609069 18472094 14724832 12666154 18420326 12958196 18395095 16136751 11481614 15673190 18705752 15996030 15925388 17766677 12389079 14748882 14716833 15362042 12445418 14512876 12667390 12546737 18418968 18339082 16033810 18412020 16097048 18376398 17900296 12632512 13678700 18395914 18205269 17761835 15650968 17805973 18279442 17481882 10355542 18472332 15893842 16638106 17721639 15370692 18263696 12649538 15959796 18187930 15052691 15818738 17565644 17869086 12586293 17922224 18429990 17714472 18156304 18251166 18317297 15123356 12741479 17976157 16027843 16011737 16116963 15876570 12445421 17640975 17525996
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3412878042
MESH:D008107 Liver Diseases Acetaminophen 4.0719460945 16611625 19784758 11587558 19014921 16610002 12969438 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0715830285 16246199 15720792 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1817185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6516984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009421 Nervous System Malformations bisphenol A 10.5411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.5414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D010049 Ovarian Diseases bisphenol A 5.3311985600
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.6610548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6611896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4520887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.5116740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.5116205645
MESH:D011629 Puberty, Precocious bisphenol A 5.1210548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D019966 Substance-Related Disorders bisphenol A 4.3216684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014591 Uterine Diseases bisphenol A 5.3814652134
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:05016 Huntington's disease
KEGG:04916 Melanogenesis
KEGG:05215 Prostate cancer
KEGG:04962 Vasopressin-regulated water reabsorption
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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