AutismKB 2.0

Annotation Detail for USP8


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Basic Information Top
Gene Symbol:USP8 ( FLJ34456,HumORF8,KIAA0055,MGC129718,UBPY )
Gene Full Name: ubiquitin specific peptidase 8
Band: 15q21.2
Quick LinksEntrez ID:9101; OMIM: 603158; Uniprot ID:UBP8_HUMAN; ENSEMBL ID: ENSG00000138592; HGNC ID: 12631
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04144Endocytosis
No data
Pathway IDPathway Name
200146Internalization of ErbB1
200119ErbB2/ErbB3 signaling events
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of USP8 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of USP8 mRNAincreases expression 17879257
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of USP8 mRNAaffects expression 17555576
C008776 pelargonic acid pelargonic acid results in increased expression of USP8 mRNAincreases expression 11379042
C017947 sodium arsenite sodium arsenite results in increased expression of USP8 mRNAincreases expression 12016162
D013629 Tamoxifen Tamoxifen affects the expression of USP8 mRNAaffects expression 17555576
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of USP8 mRNAdecreases expression 11379042
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3720464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3714692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.1415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.3517306315 16712894
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 3.5712762349 3040596 8156442 7684630 6091946 16792590 19187332 15855793 12585506 17015710 18394133 12684321 10797510 20032816 16210060 11077013 10934080 11467998 15590891 15590890 170078 11742282 6091945
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0317474063 20146248
MESH:D001943 Breast Neoplasms Tamoxifen 2.0319084267 19103187 17893378 20005174 19221464 20065188 20544844 16202921 19189210 16273361 15668708 18984771 18815881 19115204 19189212 19142967 19011961 21138602 19200415 20135344 17440819 17261762 15565566 17242785 20859285 19487384 21152245 19059307 18425577 11161223 18629630 16873071 17049068 19066611 19289846 20390343 18855134 19244106 16818667 19288272 19155303 18997820 18351453 18821012 19410462
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 2.0311921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.7615590891 8156442 12507178
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.753084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.7516507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.7516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8220419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8218572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1719524636 20056578
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0716919318 15861022 16105132 17110522 17681005 17333356 11677210
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 4.4512956900 18759878 15491423
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 5.0917010967
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516781746 11287661 19923254 18713872 19164858 10915739 16393943 11461765 14725611 19739265 16227642 17906064 11834606 10663392 15619225 19416960 12392966 12153990 2444490 12705907 17562736 18071297 19370779 11739529 19085960 11743745 10774834 19420014 16109766 11529661 14550746 17522070 15968718 12958197 14986274 12540782 16177239 12594235 16485898 16081117 11421492
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2120544844 16202921 19155303 17893378
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 5.018156442
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 6.1418447907
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6415345470
MESH:D005234 Fatty Liver Tamoxifen 8.6419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.0816452187
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D006689 Hodgkin Disease sodium arsenite 3.4012676792
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.8611019492 10880147
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2317937319
MESH:D007248 Infertility, Male sodium arsenite 7.2312646999 15346721
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007674 Kidney Diseases Acetaminophen 6.4515629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.4520008137
MESH:D007680 Kidney Neoplasms Tamoxifen 3.2718625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 11587558 19014921 16611625 19784758 12587719 16610002 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.9821137059 20195826
MESH:D008113 Liver Neoplasms sodium arsenite 7.9815276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 7.9816684651
MESH:D008171 Lung Diseases sodium arsenite 3.3519095001
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5720135361 20464547 6695378 17053015 18816296 18520028 18569708 20064080 20869020
MESH:D008175 Lung Neoplasms sodium arsenite 3.5716712894 15276417 17306315 19931552 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 3.5718625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7911731420 19196722 14580682 16827153 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma sodium arsenite 3.4416487513 19082730
MESH:D008545 Melanoma Tamoxifen 3.4412393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.4311141357
MESH:D009369 Neoplasms sodium arsenite 5.4311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 10.7220056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 10.721670384
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19189210 19200415
MESH:D009436 Neural Tube Defects sodium arsenite 3.3112854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.988156442 6091945 6091946 18394133 12585506 11077013 3040596
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5017306315 15276417
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.4817292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.4816039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.4815067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 6.0714606601
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.607692837 20219652 16940033
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.5618447907
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.8419050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.7215015336 12617775
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.9519075512
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 6.0919755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 6.0918572023 19524636
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.9519075512 19050374
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0112854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8517053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.8516712894 17306315 11723127 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8517572228 8653321 16712894
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014652 Vascular Diseases sodium arsenite 4.8217056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
Pathway ID Pathway Name
KEGG:04144 Endocytosis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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