AutismKB 2.0

Annotation Detail for MTMR6


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Basic Information Top
Gene Symbol:MTMR6 ( - )
Gene Full Name: myotubularin related protein 6
Band: 13q12.13
Quick LinksEntrez ID:9107; OMIM: 603561; Uniprot ID:MTMR6_HUMAN; ENSEMBL ID: ENSG00000139505; HGNC ID: 7453
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00051Fructose and mannose metabolism
No data
No data
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MTMR6 mRNAincreases expression 18648102
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MTMR6 mRNAdecreases expression 19150397
C014347 decitabine decitabine results in increased expression of MTMR6 mRNAincreases expression 19151715
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of MTMR6 mRNAdecreases expression 17681415
C006253 pirinixic acid pirinixic acid results in increased expression of MTMR6 mRNAincreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms decitabine 2.5418320071 19208741
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.777296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6719215824
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.437505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4320889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.729022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.7219176532
MESH:D003110 Colonic Neoplasms decitabine 2.3817616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2814531868 8156756 11906362 11298694 2524372 18759878 8970840 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0318289764 9328219 18692083 6679447 11289319 1440618 8291058 16192314 18648102 7440962 6482804 9653073 9022650
MESH:D004487 Edema perfluorooctanoic acid 8.2417259670 12083418
MESH:D004487 Edema pirinixic acid 8.2412083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.7319294695
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.633581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.6320426865
MESH:D005234 Fatty Liver pirinixic acid 3.1419236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006258 Head and Neck Neoplasms decitabine 3.7119215824
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006529 Hepatomegaly perfluorooctanoic acid 10.363609246
MESH:D006529 Hepatomegaly pirinixic acid 10.3616221962 18467677 19772884 19176532
MESH:D006930 Hyperalgesia perfluorooctanoic acid 4.1412083418
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007248 Infertility, Male decitabine 3.4217581917
MESH:D007249 Inflammation perfluorooctanoic acid 3.2112083418
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.276582329
MESH:D007938 Leukemia decitabine 3.2218980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.3717236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4218704418 17679729 18206229 19010910 19387464 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 6.0718055864
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.778812269
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 5.0618709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 5.0620007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.731399818 598648 3712494 6587162
MESH:D008223 Lymphoma decitabine 3.6619470736
MESH:D008545 Melanoma decitabine 2.2816505122 17785578
MESH:D009101 Multiple Myeloma decitabine 3.5918172295
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5619010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms decitabine 5.5319470736 19116145 17925555
MESH:D009369 Neoplasms pirinixic acid 5.5317405874
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.136679447
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.449802331
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.776482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010051 Ovarian Neoplasms decitabine 2.7319259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 2.8619294695
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 4.9317132714
MESH:D055728 Primary Myelofibrosis decitabine 5.2117616702
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012208 Rhabdomyosarcoma decitabine 4.8119155313
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.163712494 7505956 1399818 6587162 6582329
MESH:D013964 Thyroid Neoplasms decitabine 8.1617967635
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.558074119
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.5517616700 19087683
MESH:D014604 Uveal Neoplasms decitabine 5.5217785578
Pathway ID Pathway Name
KEGG:00051 Fructose and mannose metabolism
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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