AutismKB 2.0

Annotation Detail for MTMR7


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Basic Information Top
Gene Symbol:MTMR7 ( DKFZp781E194,MGC163449,MGC163451 )
Gene Full Name: myotubularin related protein 7
Band: 8p22
Quick LinksEntrez ID:9108; OMIM: 603562; Uniprot ID:MTMR7_HUMAN; ENSEMBL ID: ENSG00000003987; HGNC ID: 7454
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00051Fructose and mannose metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MTMR7 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of MTMR7 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of MTMR7 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of MTMR7 mRNAincreases expression 18648102
D003513 Cycloheximide Cycloheximide results in increased expression of MTMR7 mRNAincreases expression 19684285
D003513 Cycloheximide [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of MTMR7 mRNAaffects cotreatment|increases expression 19684285
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of MTMR7 mRNAaffects cotreatment|increases expression 17347304
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of MTMR7 mRNAaffects cotreatment|increases expression 17347304
D007657 Ketone Bodies Ketone Bodies results in decreased expression of MTMR7 mRNAdecreases expression 16807920
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MTMR7 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of MTMR7 mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of MTMR7 mRNA]decreases expression|increases reaction 20059764
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of MTMR7 mRNAaffects cotreatment|increases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MTMR7 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of MTMR7 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of MTMR7 mRNAincreases expression 19684285
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.2717676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2714514962 15322242 11752688
MESH:D000138 Acidosis Ethanol 4.7311192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.5815451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000853 Anophthalmos Ethanol 5.0415513904
MESH:D001008 Anxiety Disorders Ethanol 4.1411141031
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002056 Burns Ethanol 4.8716374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.793581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.7918788625 15289165 15763234
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D006332 Cardiomegaly Ethanol 7.1419332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.1416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.046135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.047505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.279022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D002971 Cleft Lip Ethanol 3.6615513904
MESH:D002972 Cleft Palate Ethanol 6.1615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1615340226 8697196 12621046 15668235 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6811198716 19302082 10194807 15451039 11873399 15451040 15513904
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6810048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.6318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.6318551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0111298694 12868966 2524372 8156756 11906362 18759878 14531868 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.529328219 6679447 9022650 18692083 8291058 16192314 9653073 7440962 18648102 11289319 18289764 1440618 6482804
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.5211566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.5220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1715322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.763581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.7616704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethanol 14.3619236843 16409862 18620774
MESH:D005234 Fatty Liver Fish Oils 14.3618620774
MESH:D005234 Fatty Liver pirinixic acid 14.3619236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5416946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Ethanol 4.9615046732
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly pirinixic acid 8.9916221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9915340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3115340226 16354765 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Ethanol 3.8518783367
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Fish Oils 4.9415752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.7711484837
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9312200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 10.7015513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.7016580747
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2516705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.256582329
MESH:D007859 Learning Disorders Ethanol 4.4215451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9317676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3318295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5618166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5612878042
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.8717347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.667678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.6620007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.6616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.372876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.37598648 1399818 3712494 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3712151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008569 Memory Disorders Ethanol 4.3918411066 15451040
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.1518551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.1518551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.0316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.0316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 16.036482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0212384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11399792 11896295 11222880
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012640 Seizures 2,4-dinitrotoluene 10.5518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.5518551238
MESH:D012640 Seizures Ethanol 10.559754883
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.709211565 17918041 11906479 9562338 17189318 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.429754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.016582329 7505956 6587162 1399818 3712494
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.638074119
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
KEGG:00051 Fructose and mannose metabolism
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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