AutismKB 2.0

Annotation Detail for INA


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Basic Information Top
Gene Symbol:INA ( FLJ18662,FLJ57501,MGC12702,NEF5,NF-66,TXBP-1 )
Gene Full Name: internexin neuronal intermediate filament protein, alpha
Band: 10q24.33
Quick LinksEntrez ID:9118; OMIM: 605338; Uniprot ID:AINX_HUMAN; ENSEMBL ID: ENSG00000148798; HGNC ID: 6057
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2151Neuroblastoma
2248Cytomegalovirus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of INA mRNAaffects expression 16483693
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of INA proteindecreases expression 16483693
D001104 Arbutin Arbutin results in decreased expression of INA mRNAdecreases expression 17103032
D005038 Ethylnitrosourea Ethylnitrosourea results in increased expression of INA mRNAincreases expression 15954086
D008713 Methimazole Methimazole results in decreased expression of INA mRNAdecreases expression 17403546
C494474 perchlorate perchlorate results in decreased expression of INA mRNAdecreases expression 17403546
D011441 Propylthiouracil Propylthiouracil results in decreased expression of INA mRNAdecreases expression 17403546
D013974 Thyroxine Thyroxine results in increased expression of INA mRNAincreases expression 17403546
C024746 tobacco tar tobacco tar results in decreased expression of INA mRNAdecreases expression 19559774
D014212 Tretinoin Tretinoin results in decreased expression of INA mRNAdecreases expression 16604517
C025643 vinclozolin vinclozolin affects the expression of INA mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000236 Adenoma Ethylnitrosourea 3.816695378
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 9.9719483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.9716206674 16197459
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0414991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4518412241 16436596 15144691 16357521 16651633
MESH:D001943 Breast Neoplasms Tretinoin 2.2516443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.901917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316096774 16051514
MESH:D006332 Cardiomegaly Thyroxine 4.1918093424
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 7.8316003739
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.8319559774
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.2517160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8210589399 9664655 17551590 9142499 16925845 9125849 9224671 8800419 9211117 14991402
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.2518357618
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.7317994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D005909 Glioblastoma Ethylnitrosourea 7.7816436596
MESH:D005909 Glioblastoma Tretinoin 7.7817312396
MESH:D005910 Glioma Ethylnitrosourea 3.5516357521 16651633 18412241
MESH:D006042 Goiter perchlorate 5.4918801409
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006980 Hyperthyroidism Methimazole 5.8114678291
MESH:D007037 Hypothyroidism Methimazole 12.6818031379
MESH:D007037 Hypothyroidism Propylthiouracil 12.6818031379 8137927
MESH:D007248 Infertility, Male vinclozolin 3.1516467254
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0717551590 15992940
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.0717379185
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617294898 16331271 19035177 15748426 17339181 17368321 17107899 16140955 17361223 16766008 19075265 12679006 16891316 16935935 19642359 17301526 17712046 19225113 9834237 17217047 16823087 17506722 17649720 19029980 16788101
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6317703301 16271038 6695378 16019985
MESH:D008223 Lymphoma Ethylnitrosourea 4.0615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.2615375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.6118041768 10767621 10838139
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008579 Meningioma Ethylnitrosourea 6.2517943659
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009369 Neoplasms Tretinoin 2.4816594593 16946489
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6216707424
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.6516003739 16651423 17160924
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.2517160924
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3916936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.1318042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.6816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4015790496
MESH:D013959 Thyroid Diseases Thyroxine 5.9019910387
MESH:D013964 Thyroid Neoplasms Propylthiouracil 7.8615710170
MESH:D013964 Thyroid Neoplasms Tretinoin 7.8616026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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