AutismKB 2.0

Annotation Detail for KRT75


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Basic Information Top
Gene Symbol:KRT75 ( K6HF,KB18,PFB )
Gene Full Name: keratin 75
Band: 12q13.13
Quick LinksEntrez ID:9119; OMIM: 609025; Uniprot ID:K2C75_HUMAN; ENSEMBL ID: ENSG00000170454; HGNC ID: 24431
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Pseudofolliculitis barbae, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of KRT75 mRNAincreases expression 18648102
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of KRT75 mRNAdecreases expression 15982314
D000082 Acetaminophen Acetaminophen affects the expression of KRT75 mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in decreased expression of KRT75 mRNAdecreases expression 15982314
D004958 Estradiol Estradiol affects the expression of KRT75 mRNAaffects expression 14699072
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KRT75 mRNAaffects binding|decreases expression|increases activity 19710929
D015474 Isotretinoin Isotretinoin results in decreased expression of KRT75 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin metabolite results in decreased expression of KRT75 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of KRT75 mRNAdecreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 4.8718769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.2218769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.6616232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.8618769834 16185265
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.4011289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8019483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8016197459 16206674
MESH:D001943 Breast Neoplasms alitretinoin 2.0116344269
MESH:D001943 Breast Neoplasms Estradiol 2.0116675129 17018787 12948864 14630087 17289903 17261762 18497071 19861407
MESH:D001943 Breast Neoplasms Tretinoin 2.0116873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.817296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.813084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.811917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 5.2711237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.2716096774 16051514
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Tretinoin 7.6617460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.197505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.4319486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.4319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.1318769834 9879862
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.1310589399 8800419 17551590 9224671 16925845 9125849 14991402 9664655 9211117 9142499
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.1014531868 11298694 2524372 8156756 11906362 8970840 12868966 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.752952479 3621924
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 3.9118289764 6482804 8291058 11289319 18692083 1440618 9022650 16192314 6679447 18648102 7440962 9328219 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9119370779 16081117 10774834 18071297 14550746 11287661 2444490 16781746 19164858 12958197 12153990 17522070 18713872 14725611 16393943 10915739 19420014 11834606 12392966 11461765 12594235 19085960 10663392 15968718 12540782 11421492 19923254 17906064 16485898 12705907 15619225 16227642 17562736 19416960 11529661 14986274 11739529 16177239 11743745 16109766 19739265
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.9111473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9116569247
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tretinoin 3.7516938888 9664655
MESH:D005234 Fatty Liver pirinixic acid 3.0119236843 20131406
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Tretinoin 3.8217994277
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0114991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.796705139
MESH:D006529 Hepatomegaly pirinixic acid 3.3016221962 19176532 19772884 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006930 Hyperalgesia Acetaminophen 8.2716870215
MESH:D006930 Hyperalgesia Tretinoin 8.2716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D007333 Insulin Resistance Estradiol 7.6916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.6916306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.408074119 9022650
MESH:D007569 Jaw Abnormalities Tretinoin 4.1415992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.9816144296
MESH:D007674 Kidney Diseases Acetaminophen 6.3115629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.3115618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.046582329
MESH:D007680 Kidney Neoplasms Estradiol 8.0415610895
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3019029980 19642359 19225113 17294898 17217047 17361223 12679006 19035177 16331271 17339181 16140955 16823087 17506722 17712046 15748426 9834237 16935935 16891316 17301526 16788101 17368321 19075265 16766008 17107899 17649720
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5815474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5816248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6719460945 12587719 19784758 11587558 19014921 16610002 12969438 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8915890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.671399818 598648 6587162 3712494
MESH:D008175 Lung Neoplasms alitretinoin 3.2616413115
MESH:D008175 Lung Neoplasms Isotretinoin 3.2615899809
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7011807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Isotretinoin 3.8317237267
MESH:D008545 Melanoma Tretinoin 3.8316752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8716411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009369 Neoplasms alitretinoin 8.9716946489
MESH:D009369 Neoplasms pirinixic acid 8.9717405874
MESH:D009369 Neoplasms Tretinoin 8.9716594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009421 Nervous System Malformations Estradiol 10.6311399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.639125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.726679447
MESH:D009436 Neural Tube Defects Tretinoin 7.729142499
MESH:D009447 Neuroblastoma Isotretinoin 4.1517368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010051 Ovarian Neoplasms Estradiol 5.0219401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0216936753
MESH:D010146 Pain Acetaminophen 7.2616870215
MESH:D010146 Pain Tretinoin 7.2616870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:D017499 Porokeratosis alitretinoin 6.3816144296
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 5.2218769834
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011507 Proteinuria Tretinoin 3.8616636307
OMIM:612318 PSEUDOFOLLICULITIS BARBAE marker/mechanism
MESH:D011596 Psychomotor Disorders Isotretinoin 6.2618769834
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7016467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.756587162 6582329 1399818 7505956 3712494
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7517045167 16026305
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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