AutismKB 2.0

Annotation Detail for P2RX6


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Basic Information Top
Gene Symbol:P2RX6 ( MGC129625,P2RXL1,P2X6,P2XM )
Gene Full Name: purinergic receptor P2X, ligand-gated ion channel, 6
Band: 22q11.21
Quick LinksEntrez ID:9127; OMIM: 608077; Uniprot ID:P2RX6_HUMAN; ENSEMBL ID: ENSG00000099957; HGNC ID: 8538
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
hypertension
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of P2RX6 mRNAincreases expression 19933214
D000643 Ammonium Chloride Ammonium Chloride affects the expression of P2RX6 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of P2RX6 mRNAdecreases expression 16644059
D000431 Ethanol Ethanol results in decreased expression of P2RX6 mRNAdecreases expression 17920746
D005419 Flavonoids Flavonoids results in increased expression of P2RX6 mRNAincreases expression 18035473
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of P2RX6 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 10.0618926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 10.0611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 12.0618287403
MESH:D000138 Acidosis Ethanol 12.0611192467
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.8415451039 15451040
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000853 Anophthalmos Ethanol 5.2415513904
MESH:D001008 Anxiety Disorders Ethanol 4.2611141031
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002056 Burns Ethanol 5.0716374292
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2010355542 16124888 15673190 16011737 15700767 16050911 16227642 16192424 15721981 3786805 16097048 18705752
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.3418788625
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.3415763234 18788625 15289165
MESH:D006332 Cardiomegaly Ethanol 7.3619332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.3616120746 18850075 18670907
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002971 Cleft Lip Ethanol 3.7315513904
MESH:D002972 Cleft Palate Ethanol 6.3215513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.3216354765 8697196 15340226 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.7115513904 19302082 10194807 15451039 11198716 15451040 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.7120055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.716884620 19085960 10092053 7440962 11566570 21278145 6623471 10915739 2869522 3786805 15027814 16227642 7179309 3732212 15998439 19336974 7120509 17522070 9327722 16177239 4309450 15968718
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.7111566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.7120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4218230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.3310568697 9294722
MESH:D004938 Esophageal Neoplasms Ethanol 2.8116704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.1312795759 19224547 15959796 61145 17595544 16045604 12631006 16239168
MESH:D005234 Fatty Liver Ethanol 9.1316409862 18620774 19236843
MESH:D005235 Fatty Liver, Alcoholic Ethanol 6.1917920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.7616946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 10.0218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 10.0220067830
MESH:D005756 Gastritis Ethanol 5.2115046732
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Ethanol 3.9718783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Flavonoids 5.4817296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4812878042 12200463
MESH:D007569 Jaw Abnormalities Ethanol 11.2315513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 11.2316580747
MESH:D007859 Learning Disorders Ethanol 4.6315451040
MESH:D017880 Limb Deformities, Congenital Ethanol 4.0317676605
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.3316221502 16239168 11408273 17157831 16943688 21278145 11903743 17334410 17174718
MESH:D008103 Liver Cirrhosis Ethanol 7.3315289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.5618295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6818210741 18205269 18705752 17721639 15370692 12445421 17708605 12958196 15650968 10355542 14620537 15362042 18054572 12667390 15931870 15959796 18395914 12741479 15925388 18187930 17922224 12898905 17823541 16033810 12389079 17766677 17944888 18251166 16015684 13678700 18317297 17631135 15338365 14724832 16638106 17525996 17761835 12546737 18006644 18263696 18166357 18376398 12632514 17640975 17869086 12586293 18472332 15123356 18481824 18418968 14716496 12609069 15730626 15876570 17481882 20821823 14748882 11481614 15673190 18420326 15893842 16097048 17698563 16011737 18412020 18339082 16136751 12632512 12445418 18395095 18277467 17976157 12666154 18429990 14512876 17557913 16248980 17900296 18472094 18279442 15057751 15996030 17565644 18156304 12649538 17714472 16116963 16192424 17805973 15818738 16027843 15052691 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.6818166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6812878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1416246199 15720792 16964402 15830285 17285989
MESH:D008108 Liver Diseases, Alcoholic Ethanol 5.0717207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9914706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7319294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.3712014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3712151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008569 Memory Disorders Ethanol 4.5715451040 18411066
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0612384795
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511118676 11896295 11222880 11399792
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012640 Seizures Ethanol 3.379754883
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1716192470
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Ethanol 3.859562338 17918041 16755016 11906479 17189318 9211565
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.569754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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