Gene Symbol:	CCNB2 ( HsT17299 )
Gene Full Name:	cyclin B2
Band:	15q22.2
Quick Links	Entrez ID:9133; OMIM: 602755; Uniprot ID:CCNB2_HUMAN; ENSEMBL ID: ENSG00000157456; HGNC ID: 1580
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
hsa04914	Progesterone-mediated oocyte maturation
hsa04110	Cell cycle
hsa04114	Oocyte meiosis
hsa04115	p53 signaling pathway

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of CCNB2 mRNA	increases expression	20826375
C063002	2,3-dimethoxy-1,4-naphthoquinone	2,3-dimethoxy-1,4-naphthoquinone results in increased expression of CCNB2 mRNA	increases expression	19031421 17547211
C010914	2,4-diaminotoluene	2,4-diaminotoluene results in increased expression of CCNB2 mRNA	increases expression	20713471
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene results in increased expression of CCNB2 mRNA	increases expression	20406850
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of CCNB2 mRNA	increases expression	18648102
D000082	Acetaminophen	Acetaminophen affects the expression of CCNB2 mRNA	affects expression	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of CCNB2 mRNA	decreases expression	17942131
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of CCNB2 mRNA	increases expression	17023530
D000965	Antimony	Antimony results in increased expression of CCNB2 mRNA	increases expression	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of CCNB2 mRNA	increases expression	17547211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CCNB2 mRNA	increases expression	17547211
C015001	arsenite	arsenite results in decreased expression of CCNB2 mRNA	decreases expression	18929588
D001542	Benomyl	CCNB2 protein results in increased susceptibility to Benomyl	increases response to substance	11960377
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CCNB2 mRNA	decreases expression	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CCNB2 mRNA	decreases expression	17942131 20504355
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CCNB2 mRNA	decreases expression	20382639
C095105	bexarotene	bexarotene results in decreased expression of CCNB2 mRNA	decreases expression	17849452
C006780	bisphenol A	bisphenol A affects the expression of CCNB2 mRNA	affects expression	19490990
C006780	bisphenol A	bisphenol A results in increased expression of CCNB2 mRNA	increases expression	16474171
C006780	bisphenol A	bisphenol A results in increased expression of CCNB2 mRNA	increases expression	20826375
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of CCNB2 mRNA	decreases expression	17942131
D019819	Budesonide	Budesonide results in decreased expression of CCNB2 mRNA	decreases expression	17163412
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of CCNB2 mRNA	increases expression	15003993
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CCNB2 mRNA	increases expression	17484886
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNB2 mRNA]	increases expression\|increases reaction	16006527
D002857	Chromium	Chromium results in increased expression of CCNB2 mRNA	increases expression	17547211
C030123	coumarin	coumarin results in decreased expression of CCNB2 mRNA	decreases expression	18480146
D016572	Cyclosporine	Cyclosporine results in decreased expression of CCNB2 mRNA	decreases expression	20106945
D016572	Cyclosporine	Cyclosporine results in decreased expression of CCNB2 mRNA	decreases expression	17942131
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of CCNB2 mRNA	increases expression	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNB2 mRNA]	decreases reaction\|increases expression	17854601
D004317	Doxorubicin	CCNB2 protein affects the susceptibility to Doxorubicin	affects response to substance	16217747
D004642	Emodin	Emodin results in decreased expression of CCNB2 mRNA	decreases expression	16045814
C007610	equol	equol results in decreased expression of CCNB2 mRNA	decreases expression	16865672
D004958	Estradiol	Estradiol results in increased expression of CCNB2 mRNA	increases expression	16474171 15897899
D004958	Estradiol	Estradiol results in increased expression of CCNB2 mRNA	increases expression	20826375
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CCNB2 mRNA	affects expression	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CCNB2 mRNA	increases expression	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCNB2 mRNA	affects cotreatment\|increases expression	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CCNB2 mRNA	affects expression	17351261
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of CCNB2 mRNA	increases expression	17317680
D015073	2-Acetylaminofluorene	TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of CCNB2 mRNA]	affects expression\|affects reaction	17317680
D005472	Fluorouracil	Fluorouracil results in decreased expression of CCNB2 mRNA	decreases expression	16709241 16557594
D005472	Fluorouracil	Fluorouracil results in decreased expression of CCNB2 protein	decreases expression	17982488
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of CCNB2 mRNA]	affects reaction\|decreases expression	15016801
D019833	Genistein	Genistein affects the expression of CCNB2 mRNA	affects expression	18847459
D019833	Genistein	Genistein results in decreased expression of CCNB2 mRNA	decreases expression	16865672
D019833	Genistein	Genistein results in increased expression of CCNB2 mRNA	increases expression	16474171
C051890	irinotecan	CCNB2 protein results in increased susceptibility to irinotecan	increases response to substance	16734730
C051890	irinotecan	irinotecan metabolite results in decreased expression of CCNB2 mRNA	decreases expression	15956246
C051890	irinotecan	irinotecan results in decreased expression of CCNB2 mRNA	decreases expression	15956246
D007529	Isoflavones	Isoflavones results in decreased expression of CCNB2 mRNA	decreases expression	17374662
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CCNB2 mRNA	decreases expression	12057914
D008345	Manganese	Manganese results in decreased expression of CCNB2 mRNA	decreases expression	17175027
C025340	manganese chloride	manganese chloride results in decreased expression of CCNB2 mRNA	decreases expression	17175027
D008628	Mercury	Mercury results in increased expression of CCNB2 mRNA	increases expression	17547211
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of CCNB2 mRNA	increases expression	20713471
D009151	Mustard Gas	Mustard Gas results in increased expression of CCNB2 mRNA	increases expression	15674843
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of CCNB2 mRNA	decreases expression	15585362
D009532	Nickel	Nickel results in increased expression of CCNB2 mRNA	increases expression	19031421
C022838	nickel chloride	nickel chloride results in increased expression of CCNB2 mRNA	increases expression	17547211
D010126	Ozone	TTPA protein affects the reaction [Ozone results in increased expression of CCNB2 mRNA]	affects reaction\|increases expression	19555225
D017239	Paclitaxel	CCNB2 protein affects the susceptibility to Paclitaxel	affects response to substance	16217747
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CCNB2 mRNA]	affects reaction\|increases expression	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of CCNB2 mRNA	increases expression	19482888
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CCNB2 mRNA	affects binding\|decreases expression\|increases activity	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of CCNB2 mRNA	increases expression	17950772 18301758
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of CCNB2 mRNA]	increases expression\|increases reaction	17950772
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in increased expression of CCNB2 mRNA	increases expression	16474171
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of CCNB2 mRNA	increases expression	17547211
D011374	Progesterone	Progesterone results in increased expression of CCNB2 mRNA	increases expression	18070364
C059514	resveratrol	resveratrol results in decreased expression of CCNB2 mRNA	decreases expression	15767336
C009166	retinol acetate	retinol acetate results in increased expression of CCNB2 mRNA	increases expression	16772331
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of CCNB2 mRNA	decreases expression	16678137
C410733	scriptaid	scriptaid affects the expression of CCNB2 mRNA	affects expression	18813790
D017632	Asbestos, Serpentine	Asbestos, Serpentine results in increased expression of CCNB2 mRNA	increases expression	16251409
C017947	sodium arsenite	sodium arsenite results in decreased expression of CCNB2 mRNA	decreases expression	17998272
D014284	Triiodothyronine	Triiodothyronine results in increased expression of CCNB2 mRNA	increases expression	17403546
D016559	Tacrolimus	Tacrolimus results in decreased expression of CCNB2 mRNA	decreases expression	16574167
D013629	Tamoxifen	Tamoxifen affects the expression of CCNB2 mRNA	affects expression	17555576
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CCNB2 mRNA	increases expression	11007951
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCNB2 mRNA	affects cotreatment\|increases expression	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CCNB2 mRNA	decreases expression	16611356
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of CCNB2 mRNA	increases expression	19031421
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of CCNB2 mRNA	increases expression	19031421
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCNB2 mRNA	affects cotreatment\|affects expression	16979875
D024505	Tocopherols	Tocopherols results in increased expression of CCNB2 mRNA	increases expression	17056531
D019772	Topotecan	CCNB2 protein affects the susceptibility to Topotecan	affects response to substance	16217747
C099150	trabectedin	trabectedin results in decreased expression of CCNB2 mRNA	decreases expression	15961672
C099150	trabectedin	trabectedin results in decreased expression of CCNB2 mRNA	decreases expression	15961672
D014212	Tretinoin	Tretinoin results in decreased expression of CCNB2 mRNA	decreases expression	16574167
D014212	Tretinoin	Tretinoin results in increased expression of CCNB2 mRNA	increases expression	17198874
D014747	Vinblastine	CCNB2 protein affects the susceptibility to Vinblastine	affects response to substance	16217747
C017963	vinyl carbamate	vinyl carbamate results in increased expression of CCNB2 mRNA	increases expression	17163412
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of CCNB2 mRNA	affects cotreatment\|affects expression	16979875

Pathway ID	Pathway Name
KEGG:04110	Cell cycle
REACT:1538	Cell Cycle Checkpoints
REACT:152	Cell Cycle, Mitotic
KEGG:04114	Oocyte meiosis
KEGG:04115	p53 signaling pathway
KEGG:04914	Progesterone-mediated oocyte maturation

Desease ID	Desease Name
1712	Yersinia infection
2066	Lung cancer

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms	Tamoxifen	3.85	14745880
MESH:D000014	Abnormalities, Drug-Induced	Phenobarbital	6.05	6195326
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	6.05	11752688 14514962 15322242
MESH:D000152	Acne Vulgaris	Ethinyl Estradiol	3.24	17505938
MESH:D000169	Acrodermatitis	Zinc	4.72	17202136 17190629 16889938
MESH:D058186	Acute Kidney Injury	resveratrol	3.24	16538975
MESH:D055371	Acute Lung Injury	Lipopolysaccharides	11.70	11850527 18653653
MESH:D055371	Acute Lung Injury	Nickel	11.70	16166738
MESH:D055371	Acute Lung Injury	pirinixic acid	11.70	18653653
MESH:D000230	Adenocarcinoma	arsenic trioxide	20.58	19825857 11798837
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	20.58	20464547 20127859
MESH:D000230	Adenocarcinoma	Doxorubicin	20.58	17418594
MESH:D000230	Adenocarcinoma	Estradiol	20.58	11473722
MESH:D000230	Adenocarcinoma	Ethinyl Estradiol	20.58	14692618
MESH:D000230	Adenocarcinoma	Fluorouracil	20.58	17638652
MESH:D000230	Adenocarcinoma	Genistein	20.58	11473722
MESH:D000230	Adenocarcinoma	vinyl carbamate	20.58	17363558 16247444
MESH:D000236	Adenoma	2-Acetylaminofluorene	20.56	10737359
MESH:D000236	Adenoma	4,4'-diaminodiphenylmethane	20.56	3712494
MESH:D000236	Adenoma	Benzo(a)pyrene	20.56	6695378
MESH:D000236	Adenoma	Diethylnitrosamine	20.56	6695378 10737359
MESH:D000236	Adenoma	Methylcholanthrene	20.56	10545420 6695378
MESH:D000236	Adenoma	resveratrol	20.56	15688382
MESH:D002759	Adenoma, Bile Duct	2-Acetylaminofluorene	5.31	6705139
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	25.48	19061943 18056438 17620307 17162532 19052882 16434500
MESH:D018248	Adenoma, Liver Cell	Phenobarbital	25.48	17620307
MESH:D018248	Adenoma, Liver Cell	pirinixic acid	25.48	16434500
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	25.48	16835633
MESH:D018248	Adenoma, Liver Cell	vinyl carbamate	25.48	12371669
MESH:D000310	Adrenal Gland Neoplasms	sodium arsenite	4.00	15276417
MESH:D018246	Adrenocortical Adenoma	sodium arsenite	4.20	16712894 17306315
MESH:D000419	Albuminuria	Doxorubicin	3.89	21441931
MESH:D000505	Alopecia	Isoflavones	7.72	17569567
MESH:D000505	Alopecia	Tretinoin	7.72	15955085
MESH:D000544	Alzheimer Disease	Ozone	5.48	15513908
MESH:D000544	Alzheimer Disease	resveratrol	5.48	16162502 16183991
MESH:D000544	Alzheimer Disease	Zinc	5.48	16410023 16325427 16580781 17119284
MESH:D000740	Anemia	Fluorouracil	6.69	17963324 16511603 15504547
MESH:D000740	Anemia	Tetrachlorodibenzodioxin	6.69	11748828
MESH:D000755	Anemia, Sickle Cell	Zinc	4.25	16916123

AutismKB 2.0

Annotation Detail for CCNB2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics