AutismKB 2.0

Annotation Detail for SYNGR1


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Basic Information Top
Gene Symbol:SYNGR1 ( MGC:1939 )
Gene Full Name: synaptogyrin 1
Band: 22q13.1
Quick LinksEntrez ID:9145; OMIM: 603925; Uniprot ID:SNG1_HUMAN; ENSEMBL ID: ENSG00000100321; HGNC ID: 11498
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2045Bipolar disorder
2069Schizophrenia
Desease Name
bipolar disorder
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SYNGR1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of SYNGR1 mRNAdecreases expression 19128835
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of SYNGR1 mRNAaffects cotreatment|affects expression 17330099
D002117 Calcitriol Calcitriol results in decreased expression of SYNGR1 mRNAdecreases expression 16002434
D000431 Ethanol Ethanol results in decreased expression of SYNGR1 mRNAdecreases expression 15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SYNGR1 mRNAincreases expression 17555576
D005419 Flavonoids Flavonoids results in decreased expression of SYNGR1 mRNAdecreases expression 18035473
D015735 Mifepristone Mifepristone results in decreased expression of SYNGR1 mRNAdecreases expression 17584828
D010795 Phthalic Acids Phthalic Acids results in decreased expression of SYNGR1 mRNAdecreases expression 15728792
D024505 Tocopherols Tocopherols results in increased expression of SYNGR1 mRNAincreases expression 17654050
D014303 Trinitrotoluene Trinitrotoluene affects the expression of SYNGR1 mRNAaffects expression 21346803
D014810 Vitamin E Vitamin E results in increased expression of SYNGR1 mRNAincreases expression 19244175
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of SYNGR1 mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.3617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 9.367525203
MESH:D000138 Acidosis Ammonium Chloride 10.8718287403
MESH:D000138 Acidosis Ethanol 10.8711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3511798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3514692618
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4515451039 15451040
MESH:D000853 Anophthalmos Ethanol 4.9215513904
MESH:D001008 Anxiety Disorders Ethanol 4.0711141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.4120106747
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7516206674
MESH:D001943 Breast Neoplasms Calcitriol 2.1711237771
MESH:D001943 Breast Neoplasms decitabine 2.1718320071 19208741
MESH:D001943 Breast Neoplasms vorinostat 2.1716144943
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002056 Burns Ethanol 4.7616374292
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.3016217749 15073043 15553829 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.3015289165 15763234 18788625
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9611237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.9619215824
MESH:D006332 Cardiomegaly Ethanol 3.4819332462
MESH:D002386 Cataract Trinitrotoluene 3.9114694615 15817613
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9317681005 17110522 16105132 11677210 16919318 15861022 17333356
MESH:D002971 Cleft Lip Ethanol 3.6215513904
MESH:D002972 Cleft Palate Ethanol 3.2015513904
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6020501625
MESH:D015179 Colorectal Neoplasms decitabine 2.6018981723
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.4715095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9610525206
MESH:D019465 Craniofacial Abnormalities Ethanol 3.9615451039 11873399 19302082 11198716 15513904 10194807 15451040
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9619769572
MESH:D003490 Cyanosis Trinitrotoluene 5.0318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003967 Diarrhea vorinostat 4.5920479100
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.5011566570
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 4.5018551238 21346803
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.4115138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.4112538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.2519294695
MESH:D004715 Endometriosis Mifepristone 4.4416134523
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.7712903497
MESH:D004938 Esophageal Neoplasms Ethanol 4.7716704527
MESH:D005221 Fatigue vorinostat 5.7120479100
MESH:D005234 Fatty Liver arsenic trioxide 13.6715073043
MESH:D005234 Fatty Liver Ethanol 13.6718620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6715345470
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8017920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4216946407 10194807 15451040 15513904
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005756 Gastritis Ethanol 4.8315046732
MESH:D006258 Head and Neck Neoplasms decitabine 3.5419215824
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0316080930
MESH:D006529 Hepatomegaly Trinitrotoluene 4.3415817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006930 Hyperalgesia Ethanol 3.7818783367
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male decitabine 11.6417581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.6417937319
MESH:D007248 Infertility, Male Trinitrotoluene 11.6412150543
MESH:D007249 Inflammation Flavonoids 2.6817296493
MESH:D007251 Influenza, Human Vitamin E 4.3516624496
MESH:D007569 Jaw Abnormalities Ethanol 4.4915513904
MESH:D007674 Kidney Diseases Vitamin E 2.8512488133
MESH:D007859 Learning Disorders Ethanol 4.3115451040
MESH:D007938 Leukemia arsenic trioxide 6.5815070760
MESH:D007938 Leukemia decitabine 6.5818980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.8619077051
MESH:D007951 Leukemia, Myeloid decitabine 9.8617236224 19117987 18454857
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 4.0419850784 20471514 16968895 16467208 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.0418704418 18460780 17679729 19010910 19387464 18206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6018055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2611161223 16966277 17217047 19642359 15336539 19225113 19035177 16823087 9834237 17107899 12018890 15622746 16330433 19075265 16331271 17712046 15748426 12679006 16112521 15213294 11468182 17869043 16891316 12712474 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8717676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4115289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2118295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.7618166357
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.7616169303
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7617207112 17347304
MESH:D008113 Liver Neoplasms arsenic trioxide 2.3714682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.7820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5619825857 11798837
MESH:D008175 Lung Neoplasms Vitamin E 2.5611062179
MESH:D008223 Lymphoma decitabine 3.4719470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.7920479100
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.1317927505
MESH:D008545 Melanoma decitabine 2.2517785578 16505122
MESH:D008569 Memory Disorders Ethanol 4.2818411066 15451040
MESH:D008654 Mesothelioma Tocopherols 4.1315878867
MESH:D009101 Multiple Myeloma arsenic trioxide 7.5719417148 19549372 15949261 11468182 14977855
MESH:D009101 Multiple Myeloma decitabine 7.5718172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6516882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.6519010910 16882708 18608210 19157545
MESH:D009325 Nausea vorinostat 5.6620479100
MESH:D009336 Necrosis Trinitrotoluene 4.8818551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009369 Neoplasms decitabine 2.7517925555 19116145 19470736
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1710525206
MESH:D009784 Occupational Diseases Trinitrotoluene 4.4112819281 17852074 14694615
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.1712452020 16624393 19769630
MESH:D010051 Ovarian Neoplasms decitabine 8.1719259094 19331143
MESH:D010051 Ovarian Neoplasms Mifepristone 8.1716525653
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.8915580305
MESH:D010190 Pancreatic Neoplasms decitabine 8.8919294695
MESH:D010190 Pancreatic Neoplasms Ethanol 8.8912384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D055728 Primary Myelofibrosis decitabine 4.8317616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9015572423
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9119131511
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9118247401 16289102 16644109 12479363 15754350
MESH:D011471 Prostatic Neoplasms Tocopherols 1.9112504091
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9115084515
MESH:D011471 Prostatic Neoplasms vorinostat 1.9117218635
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D012208 Rhabdomyosarcoma decitabine 4.4919155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012640 Seizures Ethanol 6.629754883
MESH:D012640 Seizures Trinitrotoluene 6.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.3015817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5217007042
MESH:D013274 Stomach Neoplasms decitabine 3.5219037991
MESH:D013274 Stomach Neoplasms Ethanol 3.5218456281
MESH:D013276 Stomach Ulcer Ethanol 3.6116755016 11906479 17189318 17918041 9211565 9562338
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.339754883
MESH:D013921 Thrombocytopenia vorinostat 5.0520479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.5319014326
MESH:D013964 Thyroid Neoplasms decitabine 7.5317967635
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3412973940 11780464 20435036 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.3417616700 19087683
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms decitabine 5.0517785578
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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