AutismKB 2.0

Annotation Detail for HGS


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Basic Information Top
Gene Symbol:HGS ( HRS,Vps27,ZFYVE8 )
Gene Full Name: hepatocyte growth factor-regulated tyrosine kinase substrate
Band: 17q25.3
Quick LinksEntrez ID:9146; OMIM: 604375; Uniprot ID:HGS_HUMAN; ENSEMBL ID: ENSG00000185359; HGNC ID: 4897
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04145Phagosome
hsa04144Endocytosis
Pathway IDPathway Name
Signaling by EGFR
Pathway IDPathway Name
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200146Internalization of ErbB1
200083CXCR4-mediated signaling events
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1771Neurilemmoma
1870Drug abuse
2013Sella turcica tumor
2154Adenoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of HGS mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of HGS mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of HGS mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of HGS mRNAincreases expression 20106945
D000431 Ethanol Ethanol results in decreased expression of HGS mRNAdecreases expression 17920746
D005419 Flavonoids Flavonoids results in decreased expression of HGS mRNAdecreases expression 18035473
D008727 Methotrexate HGS protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D012643 Selenium Selenium results in increased expression of HGS mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 10.1318926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 10.1312039119
MESH:D000138 Acidosis Ethanol 4.8311192467
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.7015451040 15451039
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D000853 Anophthalmos Ethanol 5.1315513904
MESH:D001008 Anxiety Disorders Ethanol 4.2011141031
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1417286800
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Methotrexate 3.0816978400
MESH:D002056 Burns Ethanol 4.9616374292
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.843084413
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.8415763234 18788625 15289165
MESH:D006332 Cardiomegaly Ethanol 3.5619332462
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.116135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D002971 Cleft Lip Ethanol 3.6915513904
MESH:D002972 Cleft Palate Ethanol 3.2615513904
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D019465 Craniofacial Abnormalities Ethanol 3.2111198716 15451040 10194807 11873399 19302082 15513904 15451039
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.219562676 12039119
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.9418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.9418551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.4719747007
MESH:D003882 Dermatomyositis Methotrexate 5.4120191521
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.6921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.6918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.6919416960 12705907 19739265 11287661 11461765 17906064 10663392 12958197 2444490 10915739 11743745 16781746 16393943 15968718 15619225 16177239 18713872 11421492 14550746 19085960 16081117 17522070 12153990 18071297 16485898 16227642 19164858 11834606 12392966 14725611 10774834 14986274 12594235 16109766 19923254 19420014 19370779 12540782 11739529 11529661 17562736
MESH:D056486 Drug-Induced Liver Injury Ethanol 12.6911566570
MESH:D056486 Drug-Induced Liver Injury Selenium 12.6915131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004938 Esophageal Neoplasms Ethanol 2.8016704527
MESH:D005234 Fatty Liver Cyclosporine 8.7319224547
MESH:D005234 Fatty Liver Ethanol 8.7319236843 18620774 16409862
MESH:D005235 Fatty Liver, Alcoholic Ethanol 6.0417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.6416946407 15513904 15451040 10194807
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005756 Gastritis Acetaminophen 12.4216983495
MESH:D005756 Gastritis Ethanol 12.4215046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006086 Graft vs Host Disease Methotrexate 5.4516518429
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006930 Hyperalgesia Acetaminophen 8.4616870215
MESH:D006930 Hyperalgesia Ethanol 8.4618783367
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007249 Inflammation Flavonoids 2.7517296493
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007569 Jaw Abnormalities Ethanol 4.6515513904
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 6.2215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.2218776723 10903974 8314463
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.5716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.5712371664
MESH:D007805 Language Development Disorders Methotrexate 5.369562676
MESH:D007859 Learning Disorders Ethanol 4.5215451040
MESH:D017880 Limb Deformities, Congenital Ethanol 3.9817676605
MESH:D008103 Liver Cirrhosis Ethanol 7.5415289165
MESH:D008103 Liver Cirrhosis Methotrexate 7.5414986274
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.4318295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.3118166357
MESH:D008107 Liver Diseases Acetaminophen 1.6719784758 16610002 12969438 16611625 19460945 11587558 19014921 12587719
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.9617347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.227678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.682876784 6135515 2876786
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.4018516814
MESH:D008223 Lymphoma Methotrexate 4.1217352296
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008569 Memory Disorders Ethanol 4.4718411066 15451040
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D052016 Mucositis Methotrexate 5.6217488658
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.5018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.5018551238 7678174
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.6616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.6616049721
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0412384795
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011565 Psoriasis Cyclosporine 6.1416882103
MESH:D011565 Psoriasis Methotrexate 6.1417410198
MESH:D051437 Renal Insufficiency Methotrexate 5.0217352296
MESH:D012640 Seizures 2,4-dinitrotoluene 10.8118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.8118551238
MESH:D012640 Seizures Ethanol 10.819754883
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Ethanol 3.7717189318 17918041 16755016 11906479 9562338 9211565
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.489754883
MESH:D013576 Syndactyly Methotrexate 5.329562676
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2816049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.1410091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.1410091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:04144 Endocytosis
REACT:11123 Membrane Trafficking
KEGG:04145 Phagosome
REACT:9417 Signaling by EGFR
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB04272 - Citric Acid Anticoagulants;Chelating Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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