Annotation Detail for SLC6A5
Basic Information
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| Gene Symbol: | SLC6A5 ( GLYT-2,GLYT2,NET1 ) |
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| Gene Full Name: | solute carrier family 6 (neurotransmitter transporter, glycine), member 5 |
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| Band: | 11p15.1 |
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| Quick Links | Entrez ID:9152; OMIM: 604159; Uniprot ID:SC6A5_HUMAN; ENSEMBL ID: ENSG00000165970; HGNC ID: 11051 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| Amine compound SLC transporters |
| Transmembrane transport of small molecules |
| Desease ID | Desease Name |
|---|
| 2045 | Bipolar disorder |
| 2069 | Schizophrenia |
| Desease Name |
|---|
| Hyperekplexia |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of SLC6A5 mRNA | affects expression | 16483693
|
| C006632 |
arsenic trioxide |
arsenic trioxide results in increased expression of SLC6A5 mRNA | increases expression | 15761015
|
| D018038 |
Sodium Selenite |
Sodium Selenite results in decreased expression of SLC6A5 mRNA | decreases expression | 18175754
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.30 | 18287403 |
| MESH:D000230 |
Adenocarcinoma |
|
arsenic trioxide |
2.36 | 11798837 19825857 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
arsenic trioxide |
4.15 | 16206674 |
| MESH:D002051 |
Burkitt Lymphoma |
|
arsenic trioxide |
4.86 | 11589617 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
arsenic trioxide |
1.98 | 15073043 16217749 11135700 14691202 15553829 |
| MESH:D002291 |
Carcinoma, Papillary |
|
arsenic trioxide |
5.74 | 19014326 |
| MESH:D018288 |
Carcinoma, Small Cell |
|
arsenic trioxide |
4.57 | 12490120 |
| MESH:D019457 |
Chromosome Breakage |
|
Sodium Selenite |
5.41 | 15894690 |
| MESH:D015179 |
Colorectal Neoplasms |
|
arsenic trioxide |
1.87 | 20501625 |
| MESH:D023903 |
Coronary Restenosis |
|
arsenic trioxide |
4.77 | 12609071 |
| MESH:D019465 |
Craniofacial Abnormalities |
|
arsenic trioxide |
1.89 | 10525206 |
| MESH:D016757 |
Death, Sudden, Cardiac |
|
arsenic trioxide |
4.63 | 15213294 |
| MESH:D003920 |
Diabetes Mellitus |
|
Sodium Selenite |
4.19 | 16285004 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Sodium Selenite |
2.37 | 15131321 |
| MESH:D004938 |
Esophageal Neoplasms |
|
arsenic trioxide |
2.39 | 12903497 |
| MESH:D005234 |
Fatty Liver |
|
arsenic trioxide |
3.77 | 15073043 |
| MESH:D005706 |
Gallbladder Neoplasms |
|
arsenic trioxide |
4.85 | 16904648 |
| OMIM:149400 |
HYPEREKPLEXIA, HEREDITARY |
marker/mechanism |
|
| |
| MESH:D007333 |
Insulin Resistance |
|
Sodium Selenite |
3.54 | 14714311 |
| MESH:D007938 |
Leukemia |
|
arsenic trioxide |
3.01 | 15070760 |
| MESH:D015459 |
Leukemia-Lymphoma, Adult T-Cell |
|
arsenic trioxide |
4.28 | 12560223 17077332 |
| MESH:D007948 |
Leukemia, Monocytic, Acute |
|
arsenic trioxide |
5.05 | 16972261 |
| MESH:D015464 |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
|
arsenic trioxide |
3.75 | 14633726 |
| MESH:D007951 |
Leukemia, Myeloid |
|
arsenic trioxide |
4.24 | 19077051 |
| MESH:D015470 |
Leukemia, Myeloid, Acute |
|
arsenic trioxide |
2.19 | 20471514 16467208 17050201 16968895 19850784 |
| MESH:D015473 |
Leukemia, Promyelocytic, Acute |
|
arsenic trioxide |
3.48 | 12679006 19035177 16891316 16966277 12712474 19642359 19075265 15622746 9834237 17217047 16823087 15748426 17649720 16331271 11161223 11468182 17712046 12018890 15213294 17107899 17869043 19225113 16330433 16112521 15336539 |
| MESH:D015458 |
Leukemia, T-Cell |
|
arsenic trioxide |
4.94 | 16882451 |
| MESH:D008113 |
Liver Neoplasms |
|
arsenic trioxide |
2.47 | 14682389 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
arsenic trioxide |
2.98 | 20377131 |
| MESH:D008133 |
Long QT Syndrome |
|
arsenic trioxide |
3.69 | 15213294 |
| MESH:D008175 |
Lung Neoplasms |
|
arsenic trioxide |
1.87 | 19825857 11798837 |
| MESH:D016393 |
Lymphoma, B-Cell |
|
Sodium Selenite |
4.59 | 14737004 |
| MESH:D009101 |
Multiple Myeloma |
|
arsenic trioxide |
3.41 | 19417148 14977855 11468182 15949261 19549372 |
| MESH:D009182 |
Mycosis Fungoides |
|
arsenic trioxide |
5.54 | 18349030 |
| MESH:D009190 |
Myelodysplastic Syndromes |
|
arsenic trioxide |
3.36 | 16882451 16105982 |
| MESH:D009361 |
Neoplasm Invasiveness |
|
arsenic trioxide |
4.54 | 16624393 |
| MESH:D009436 |
Neural Tube Defects |
|
arsenic trioxide |
3.38 | 10525206 |
| MESH:D010051 |
Ovarian Neoplasms |
|
arsenic trioxide |
2.51 | 16624393 12452020 19769630 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
arsenic trioxide |
2.64 | 15580305 |
| MESH:D010235 |
Paraganglioma |
|
arsenic trioxide |
4.69 | 19927285 |
| MESH:D011471 |
Prostatic Neoplasms |
|
arsenic trioxide |
3.24 | 19131511 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Sodium Selenite |
3.24 | 18760546 |
| MESH:D012512 |
Sarcoma, Ewing's |
|
arsenic trioxide |
4.54 | 16646077 |
| MESH:D013274 |
Stomach Neoplasms |
|
arsenic trioxide |
1.86 | 17007042 |
| MESH:D013964 |
Thyroid Neoplasms |
|
arsenic trioxide |
3.43 | 19014326 |
| MESH:D016171 |
Torsades de Pointes |
|
arsenic trioxide |
4.70 | 15213294 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
arsenic trioxide |
2.61 | 20435036 12845720 11780464 12973940 |
| Pathway ID |
Pathway Name |
|---|
| REACT:20679 |
Amine compound SLC transporters |
| REACT:15518 |
Transmembrane transport of small molecules |
PharmGKB Accession:PA35911
| Releated gene ID |
Related gene Name |
| PA35911 | SLC6A5 |
| Releated drug ID |
Related drug Name |
| PA449841 | haloperidol |
| Drugbank ID |
Action |
Drug Name |
Description |
|---|
| DB00145 |
- |
Glycine |
Dietary supplement;Micronutrient;Non-Essential Amino Acids;Glycine Agents |
