AutismKB 2.0

Annotation Detail for SLC28A1


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Basic Information Top
Gene Symbol:SLC28A1 ( CNT1,HCNT1 )
Gene Full Name: solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
Band: 15q25.3
Quick LinksEntrez ID:9154; OMIM: 606207; Uniprot ID:S28A1_HUMAN; ENSEMBL ID: ENSG00000156222; HGNC ID: 11001
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of nucleotides
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500224Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
2106Pancreas cancer
2238Lipodystrophy
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000241 Adenosine Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 9124315
D000241 Adenosine SLC28A1 protein affects the transport of Adenosineaffects transport 9124315
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SLC28A1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC28A1 mRNAaffects expression 16483693
D001374 Azacitidine SLC28A1 protein results in increased susceptibility to Azacitidineincreases response to substance 19139132
D001374 Azacitidine SLC28A1 protein results in increased uptake of Azacitidineincreases uptake 19139132
D001374 Azacitidine [SLC28A1 protein results in increased uptake of Azacitidine] which results in decreased expression of DNMT1 proteindecreases expression|increases uptake 19139132
D001374 Azacitidine Sodium affects the reaction [SLC28A1 protein results in increased uptake of Azacitidine]affects reaction|increases uptake 19139132
D016572 Cyclosporine Cyclosporine results in decreased expression of SLC28A1 mRNAdecreases expression 20106945
D003561 Cytarabine Cytarabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]decreases reaction|increases transport 10772724
D003561 Cytarabine Cytarabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D003562 Cytidine Cytidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 9124315
D003562 Cytidine SLC28A1 protein results in increased transport of Cytidineincreases transport 10772724
D016047 Zalcitabine SLC28A1 protein results in increased uptake of Zalcitabineincreases uptake 8027026
8700147
D016047 Zalcitabine Zalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D016047 Zalcitabine Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]increases export|increases reaction 8700147
C014347 decitabine SLC28A1 protein results in increased susceptibility to decitabineincreases response to substance 19139132
D003841 Deoxycytidine SLC28A1 protein results in increased transport of Deoxycytidineincreases transport 10772724
D019259 Lamivudine Lamivudine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]decreases reaction|increases transport 10772724
C056507 gemcitabine gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]decreases reaction|increases transport 10772724
C056507 gemcitabine gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D007065 Idoxuridine Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D012964 Sodium Sodium affects the reaction [SLC28A1 protein results in increased uptake of Azacitidine]affects reaction|increases uptake 19139132
D012964 Sodium Sodium affects the reaction [SLC28A1 protein results in increased uptake of Uridine]affects reaction|increases uptake 9124315
D012964 Sodium SLC28A1 protein results in increased uptake of Sodiumincreases uptake 8700147
D013936 Thymidine Thymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 9124315
D014529 Uridine Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 9124315
D014529 Uridine Cytarabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]decreases reaction|increases transport 10772724
D014529 Uridine Cytidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 9124315
D014529 Uridine gemcitabine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]decreases reaction|increases transport 10772724
D014529 Uridine Lamivudine inhibits the reaction [SLC28A1 protein results in increased transport of Uridine]decreases reaction|increases transport 10772724
D014529 Uridine SLC28A1 protein results in increased transport of Uridineincreases transport 10772724
D014529 Uridine SLC28A1 protein results in increased uptake of Uridineincreases uptake 9124315
D014529 Uridine Sodium affects the reaction [SLC28A1 protein results in increased uptake of Uridine]affects reaction|increases uptake 9124315
D014529 Uridine Thymidine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 9124315
D014529 Uridine Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 9124315
D014529 Uridine Cytarabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D014529 Uridine gemcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D014529 Uridine Idoxuridine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D014529 Uridine SLC28A1 protein results in increased export of Uridineincreases export 8700147
D014529 Uridine SLC28A1 protein results in increased uptake of Uridineincreases uptake 8713072
8700147
D014529 Uridine Zalcitabine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D014529 Uridine Zalcitabine promotes the reaction [SLC28A1 protein results in increased export of Uridine]increases export|increases reaction 8700147
D014529 Uridine Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D014529 Uridine Zidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine]increases export|increases reaction 8700147
D015215 Zidovudine SLC28A1 protein affects the transport of Zidovudineaffects transport 9124315
D015215 Zidovudine Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 9124315
D015215 Zidovudine SLC28A1 protein results in increased uptake of Zidovudineincreases uptake 8700147
8027026
D015215 Zidovudine Zidovudine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine]decreases reaction|increases uptake 8713072
D015215 Zidovudine Zidovudine promotes the reaction [SLC28A1 protein results in increased export of Uridine]increases export|increases reaction 8700147
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.819612607
MESH:D001321 Autistic Disorder Adenosine 3.8720468076
MESH:D001943 Breast Neoplasms marker/mechanism 16837820
MESH:D001943 Breast Neoplasms decitabine 2.7018320071 19208741
MESH:D001943 Breast Neoplasms gemcitabine 2.7017039268 18382427
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 1.9621507988 12619106 12907637
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.5919215824
MESH:D009202 Cardiomyopathies Zalcitabine 4.6910591146
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0712371664
MESH:D002471 Cell Transformation, Neoplastic Cytarabine 7.078243401
MESH:D002779 Cholestasis Cyclosporine 2.9019486331
MESH:D003110 Colonic Neoplasms decitabine 4.7917616700
MESH:D003110 Colonic Neoplasms Idoxuridine 4.7915001691
MESH:D015179 Colorectal Neoplasms Azacitidine 2.8919934284
MESH:D015179 Colorectal Neoplasms decitabine 2.8918981723
MESH:D004362 Drug Toxicity Lamivudine 14.0715040536
MESH:D004362 Drug Toxicity Zalcitabine 14.077515130
MESH:D004362 Drug Toxicity Zidovudine 14.0715040536
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1219294695
MESH:D004827 Epilepsy Adenosine 4.7911404469
MESH:D005234 Fatty Liver Cyclosporine 13.3119224547
MESH:D005234 Fatty Liver Zalcitabine 13.3118299183
MESH:D005234 Fatty Liver Zidovudine 13.3118299183
MESH:D005355 Fibrosis Cyclosporine 3.1312639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006258 Head and Neck Neoplasms decitabine 3.4719215824
MESH:D006402 Hematologic Diseases Zidovudine 4.6912579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006509 Hepatitis B Lamivudine 5.0817703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.0815309715 16476009 12044531 15631357 15274664
MESH:D015658 HIV Infections Lamivudine 11.0711141242 20032539 9296927 17530837
MESH:D015658 HIV Infections Zalcitabine 11.0717457083
MESH:D015658 HIV Infections Zidovudine 11.0711698656 11141242 11363243 17358032 20032539
MESH:D006689 Hodgkin Disease Cytarabine 4.4016200630
MESH:D006973 Hypertension Cyclosporine 2.0910903974
MESH:D007248 Infertility, Male decitabine 3.1917581917
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.338314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5112371664
MESH:D007680 Kidney Neoplasms Zidovudine 7.5112579204
MESH:D007938 Leukemia Azacitidine 6.7319148494
MESH:D007938 Leukemia decitabine 6.7318980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3920370541
MESH:D007951 Leukemia, Myeloid Azacitidine 9.8419077051
MESH:D007951 Leukemia, Myeloid decitabine 9.8419117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.3018720364 17596541
MESH:D015470 Leukemia, Myeloid, Acute decitabine 4.3019387464 18460780 18206229 17679729 18704418 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4618055864
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.1719299654
MESH:D008106 Liver Cirrhosis, Experimental Adenosine 3.7418263696
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.3415890375 9163691 18177683 2125692
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.738603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6714755239
MESH:D008175 Lung Neoplasms Azacitidine 3.6721224363
MESH:D008175 Lung Neoplasms Zidovudine 3.6718800350
MESH:D008223 Lymphoma decitabine 8.1119470736
MESH:D008223 Lymphoma Zalcitabine 8.1117941976 8840982 18798262 11980663 9205081 9488045 8764131
MESH:D008545 Melanoma decitabine 2.2417785578 16505122
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.8417358032
MESH:D009006 Monosomy Azacitidine 6.0819299654
MESH:D009101 Multiple Myeloma Azacitidine 7.6419549372 18443271
MESH:D009101 Multiple Myeloma decitabine 7.6418172295
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.7819805378 17596541 18720364 17611569
MESH:D009190 Myelodysplastic Syndromes decitabine 7.7819010910 18608210 19157545 16882708
MESH:D009369 Neoplasms decitabine 2.7019116145 19470736 17925555
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.099488045 9205081 8764131
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009437 Neuralgia Zalcitabine 6.3117292584
MESH:D010051 Ovarian Neoplasms decitabine 2.6419259094 19331143
MESH:D010190 Pancreatic Neoplasms decitabine 5.7519294695
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.7516929163 18383843 17440100 11504793 18992248
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 5.2918606552
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cytarabine 4.4321297632
MESH:D055728 Primary Myelofibrosis decitabine 4.7117616702
MESH:D011471 Prostatic Neoplasms Azacitidine 4.1418324645
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D012206 Rhabdomyolysis Lamivudine 5.539296927
MESH:D012208 Rhabdomyosarcoma decitabine 4.3819155313
MESH:D013274 Stomach Neoplasms decitabine 2.7919037991
MESH:D013274 Stomach Neoplasms Zidovudine 2.7917696246
MESH:D013964 Thyroid Neoplasms decitabine 3.3117967635
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7119087683 17616700
MESH:D014604 Uveal Neoplasms decitabine 4.9117785578
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.7412579204
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
REACT:1698 Metabolism of nucleotides
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA387
    • Releated gene ID Related gene Name
    PA387SLC28A1
    Releated disease ID Related disease Name
    PA444850Waldenstrom Macroglobulinemia
    Releated drug ID Related drug Name
    PA449748gemcitabine
    PA451241ribavirin
    PA449748gemcitabine
    PA449027cladribine
    PA451261rituximab
    PA449652floxuridine
    PA451954zidovudine
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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