AutismKB 2.0

Annotation Detail for EXO1


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Basic Information Top
Gene Symbol:EXO1 ( HEX1,hExoI )
Gene Full Name: exonuclease 1
Band: 1q43
Quick LinksEntrez ID:9156; OMIM: 606063; Uniprot ID:EXO1_HUMAN; ENSEMBL ID: ENSG00000174371; HGNC ID: 3511
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
CANCER
cervical intraepithelial neoplasia grade 3
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of EXO1 mRNAincreases expression 20713471
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of EXO1 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of EXO1 mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EXO1 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of EXO1 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EXO1 mRNAdecreases expression 20382639
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of EXO1 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of EXO1 mRNAdecreases expression 20106945
C119620 kenpaullone kenpaullone results in decreased expression of EXO1 mRNAdecreases expression 17993264
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of EXO1 mRNAincreases expression 20713471
C006253 pirinixic acid pirinixic acid results in increased expression of EXO1 mRNAincreases expression 18301758
D012402 Rotenone Rotenone results in increased expression of EXO1 mRNAincreases expression 18191903
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in decreased expression of EXO1 mRNAaffects cotreatment|decreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 11752688 15322242
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 7.076695378
MESH:D000236 Adenoma Methylcholanthrene 7.0710545420 6695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9018057881 18218290 20041841
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5111922910
MESH:D001281 Atrial Fibrillation Amiodarone 3.9818651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.9719483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.9719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.9712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.0111921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.0117474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216124888 15721981 16011737 16227642 18705752 15700767 16192424 15673190 16050911 10355542 3786805 16097048
MESH:D002277 Carcinoma Methylcholanthrene 8.6310545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.6316835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.1021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1018788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9215710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2418974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.6712371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.6716192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 15340226 16354765 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.4115265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.4110092053 6884620 15027814 15998439 7440962 7179309 16227642 3786805 2869522 7120509 10915739 6623471 21278145 3732212 15968718 19085960 9327722 11566570 4309450 19336974 17522070 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Amiodarone 19.7114986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 19.7119224547 12795759 61145 15959796 17595544 12631006 16045604 16239168
MESH:D005234 Fatty Liver Cyclosporine 19.7119224547
MESH:D005234 Fatty Liver pirinixic acid 19.7119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0914633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 15.5518705752
MESH:D005355 Fibrosis Cyclosporine 15.5512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.5520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219110552 19900420
MESH:D006529 Hepatomegaly Amiodarone 15.2615265979
MESH:D006529 Hepatomegaly pirinixic acid 15.2618467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.2615340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16354765 8697196 16959395 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.988137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007037 Hypothyroidism Amiodarone 4.6517991464 18020914
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.408314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8212371664
MESH:D008064 Lipidoses Amiodarone 3.5917567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8616221502 21278145 17334410 11408273 17174718 16943688 17157831 11903743 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4512389079 12445418 16136751 17714472 15370692 18376398 16097048 18277467 17698563 18251166 17922224 16015684 14512876 18054572 17869086 14748882 15925388 18395914 15052691 16248980 18472094 15338365 16033810 12666154 15931870 17823541 18006644 17761835 16638106 15818738 12649538 18412020 17481882 18472332 14620537 18210741 17900296 14716496 18317297 17708605 17640975 17805973 12898905 12586293 15362042 15123356 12667390 15730626 18395095 12609069 18205269 15893842 17565644 12445421 15650968 15057751 14724832 17976157 18187930 11481614 18156304 15959796 18263696 15673190 17721639 15876570 20821823 10355542 12958196 13678700 12632514 12546737 16192424 18429990 16116963 18420326 12741479 17525996 12632512 17631135 16011737 17766677 16027843 18166357 17557913 17944888 18418968 18705752 14716833 18339082 15996030 18481824 18279442
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1015720792 16964402 15830285 17285989 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7916899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.6418177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.6419294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.6415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.708603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.7015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.70598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.7012151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6611989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.4412587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6518516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9518569708 20869020 18816296 20064080 20464547 18520028 20135361 17053015 6695378
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.9517909032 7750092 6695378 15390079 21163286 10545420 11893704 16337739 20512841 9230183 16271038 1399818 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9519555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 3.6411921183
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009181 Mycoses Amiodarone 5.0817974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9911141357
MESH:D009369 Neoplasms pirinixic acid 4.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 3.9618619942 15790535 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010300 Parkinson Disease Rotenone 3.0115451049 19232380 11445065 16140633 11535288 19114014 18619942 16412576 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 4.1815927086 18197244 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8912832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2418724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6310029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6316192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Amiodarone 3.4218087811
MESH:D013610 Tachycardia Amiodarone 4.4211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3219225199
MESH:D013959 Thyroid Diseases Amiodarone 12.6419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.6412697716
MESH:D013971 Thyrotoxicosis Amiodarone 5.0019584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.3417467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2117053015
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:03430 Mismatch repair
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27923
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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