AutismKB 2.0

Annotation Detail for DEPDC7


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Basic Information Top
Gene Symbol:DEPDC7 ( TR2,dJ85M6.4 )
Gene Full Name: DEP domain containing 7
Band: 11p13
Quick LinksEntrez ID:91614; OMIM: 612294; Uniprot ID:DEPD7_HUMAN; ENSEMBL ID: ENSG00000121690; HGNC ID: 29899
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by Rho GTPases
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DEPDC7 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DEPDC7 mRNAincreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DEPDC7 mRNAincreases expression 20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of DEPDC7 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in decreased expression of DEPDC7 mRNAdecreases expression 20106945
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of DEPDC7 mRNAincreases expression 17412507
D010634 Phenobarbital Phenobarbital results in increased expression of DEPDC7 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DEPDC7 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of DEPDC7 mRNAincreases expression 17426115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.4820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.4811473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 7.4815113128 15688392
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.2717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2716434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9820146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 1.9812948864 17261762 19861407 14630087 17289903 17018787 16675129 18497071
MESH:D001943 Breast Neoplasms Methylnitrosourea 1.9811306469 14633655 16253758
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.711701930 6705139 17173139 20935162 20007298
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002386 Cataract Acetaminophen 7.9810977129
MESH:D002386 Cataract Methylnitrosourea 7.9812484553
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17.4120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.4112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.4118566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 17.412727394 7505956
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6410915739 12392966 16177239 18713872 11421492 12153990 14725611 16485898 17522070 11529661 19085960 10663392 15968718 19370779 12705907 11461765 17906064 19416960 16781746 19164858 11287661 10774834 19739265 11743745 19923254 11739529 16109766 12540782 19420014 17562736 2444490 18071297 12958197 12594235 16081117 14550746 16227642 16393943 11834606 14986274 15619225
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D016889 Endometrial Neoplasms Estradiol 3.1319148513 11473722 18566989
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005234 Fatty Liver Cyclosporine 8.3819224547
MESH:D005234 Fatty Liver pirinixic acid 8.3819236843 20131406
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.5711555667
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005910 Glioma Methylnitrosourea 3.649825942
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly Phenobarbital 9.5216109766
MESH:D006529 Hepatomegaly pirinixic acid 9.5216221962 19772884 19176532 18467677
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007248 Infertility, Male Methylnitrosourea 3.957193160
MESH:D007333 Insulin Resistance Estradiol 7.6916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.6916306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.7212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.728314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 10.7215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.9515610895
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.3715526292
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3614716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3615474484
MESH:D008107 Liver Diseases Acetaminophen 4.1012587719 19460945 19014921 19784758 16610002 12969438 11587558 16611625
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8521137059 20195826
MESH:D008113 Liver Neoplasms Phenobarbital 7.858742319 15975961 19812893 19482888 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 7.8520007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.846150874 17172636 1399818 18308698 2563599
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.7716080182
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.7818816296 17053015 20064080 20464547 20869020 20135361 18520028 6695378 18569708
MESH:D008175 Lung Neoplasms Methylnitrosourea 2.7818062963
MESH:D008223 Lymphoma Methylnitrosourea 4.1811418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 5.0314633661
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.8111807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 6.8110767621 16051031 14999141 16827153 16619500 14633655 16944150 17131329 15113128 17020996 15313902 15688392 11751437 19196723 11807958 12931682 10838139
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009369 Neoplasms Benzo(a)pyrene 8.9411141357
MESH:D009369 Neoplasms Methylnitrosourea 8.9415533788
MESH:D009369 Neoplasms pirinixic acid 8.9417405874
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.7812696579
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5019348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 3.9316427766 11399458
MESH:D009442 Neurilemmoma Methylnitrosourea 5.8211555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.8516965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.8516965848
MESH:D011230 Precancerous Conditions Cyclosporine 9.6912371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.692563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5917292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5916740699
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.5912376480 15682402
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.5918155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 5.8211555667
MESH:D012640 Seizures Phenobarbital 2.8416876388 3137016 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4610029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.722093021 20155912
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7216257854 15930296 18593901
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.5711418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 8.143078959 7505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.141399818
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
REACT:11044 Signaling by Rho GTPases
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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