AutismKB 2.0

Annotation Detail for MYOM2


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Basic Information Top
Gene Symbol:MYOM2 ( TTNAP )
Gene Full Name: myomesin (M-protein) 2, 165kDa
Band: 8p23.3
Quick LinksEntrez ID:9172; OMIM: 603509; Uniprot ID:MYOM2_HUMAN; ENSEMBL ID: ENSG00000036448; HGNC ID: 7614
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001151 Arsenic Arsenic results in decreased expression of MYOM2 mRNAdecreases expression 19654921
C006780 bisphenol A bisphenol A results in increased expression of MYOM2 mRNAincreases expression 18180321
D002794 Choline Choline affects the expression of MYOM2 mRNAaffects expression 17616785
D004317 Doxorubicin Doxorubicin results in increased expression of MYOM2 mRNAincreases expression 16243910
D008044 Linuron Linuron results in increased expression of MYOM2 mRNAincreases expression 16498641
D010795 Phthalic Acids Phthalic Acids results in increased expression of MYOM2 mRNAincreases expression 15728792
C006253 pirinixic acid pirinixic acid results in increased expression of MYOM2 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Doxorubicin 2.6217418594
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.6617306315
MESH:D000419 Albuminuria Doxorubicin 4.8721441931
MESH:D020261 Arsenic Poisoning Arsenic 2.9316251483 12569548 16835338 18414634
MESH:D050197 Atherosclerosis Arsenic 3.4012928151 19371607
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.5420106747
MESH:D001321 Autistic Disorder Choline 3.3316818868
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.1414601052
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001932 Brain Neoplasms Doxorubicin 4.0717150277
MESH:D001943 Breast Neoplasms bisphenol A 2.3617123778
MESH:D001943 Breast Neoplasms Doxorubicin 2.3616595493 16264153 15634643 18382427 16935488 18628466 16115903 15939500 16322301 18695136 11325840 15136595 15668708 15994142 16826403 16096432 18234424 17369602 15993339 17983394 17426702 15567936 19526202 15692762
MESH:D002276 Carcinoid Tumor Doxorubicin 5.2516051944
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7315504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.4316507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 3.4318059187 17876044 16023760 16234567
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2716201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.1515504454 18922899 17687452
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.156189445
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3418640142
MESH:D009202 Cardiomyopathies Doxorubicin 3.7017928571 16109756 16455267 15476868 16242529 17329180 17974986 17519947 16278810 17131338 16952015 17382496 16612575 16651473 17924179 15505089 17007740 15811867 15792986 16269455 18627295 17308081 16364871 16731534 17351982
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0217334414 16243910
MESH:D002318 Cardiovascular Diseases Arsenic 3.6315738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5618022660 16973168
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D002658 Developmental Disabilities Choline 4.8516818868
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 2.5017416283
MESH:D004362 Drug Toxicity Doxorubicin 3.8718602426
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6018037988
MESH:D005234 Fatty Liver pirinixic acid 3.0420131406 19236843
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9819069698
MESH:D005534 Foot Diseases Arsenic 6.006392382
MESH:D005909 Glioblastoma Doxorubicin 3.5217150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7015692506
MESH:D006331 Heart Diseases Doxorubicin 3.6716495754 16244371 14766674 18674790 18006777 16330681 17875725 16144979 16244372 17888722 16879835 12587719 16707910
MESH:D006333 Heart Failure Doxorubicin 7.5817481944
MESH:D006333 Heart Failure pirinixic acid 7.5820558911
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1815692506
MESH:D006529 Hepatomegaly pirinixic acid 3.3516221962 18467677 19772884 19176532
MESH:D006689 Hodgkin Disease Doxorubicin 3.6518501091 15147373 17606976
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.7217050553
MESH:D006973 Hypertension Arsenic 2.9516076760 11953799 9931084
MESH:D006987 Hypesthesia Arsenic 6.0016093927
MESH:D007333 Insulin Resistance bisphenol A 7.8816393666
MESH:D007333 Insulin Resistance pirinixic acid 7.8816306350
MESH:D007642 Keratosis Arsenic 5.3912749816 16930632
MESH:D007674 Kidney Diseases Doxorubicin 3.2015699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4416707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6016085563
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7217339181
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5416595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008107 Liver Diseases Arsenic 2.5911134558
MESH:D008113 Liver Neoplasms Arsenic 4.9016368122
MESH:D008113 Liver Neoplasms pirinixic acid 4.9020007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1717085340 16842330
MESH:D008175 Lung Neoplasms Arsenic 2.8217306315 17976673 19168569
MESH:D008175 Lung Neoplasms Doxorubicin 2.8217418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6516098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9315621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1915458769
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1517638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7815792986
MESH:D052016 Mucositis Doxorubicin 5.1917415656
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction Doxorubicin 6.0419429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 6.0419151258
MESH:D017202 Myocardial Ischemia Arsenic 4.2115371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0418259882
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009401 Nephrosis Doxorubicin 5.1316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2516889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 4.3011399458 16427766
MESH:D009436 Neural Tube Defects Arsenic 3.6216620997
MESH:D009447 Neuroblastoma Doxorubicin 3.3915555623
MESH:D020078 Neurogenic Inflammation Arsenic 4.6817056641
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D012516 Osteosarcoma Doxorubicin 4.3415930896
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms Arsenic 2.8117306315
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.5116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3915371236 16905509 6392382
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6017983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6017638057
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.3510548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.6416140617
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6416740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6416868541 18437689 15749863 15897917 16888761 16729912
MESH:D011507 Proteinuria Arsenic 4.3121343184
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D051437 Renal Insufficiency Doxorubicin 4.5817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012509 Sarcoma Doxorubicin 4.2516767912 17203757 15625365 17710206 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5714601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1917846226
MESH:D012871 Skin Diseases Arsenic 2.8017548696 17453740 19834688 17050553 15952646 16759981 16702368 17938729 18709164 6392382 16353154
MESH:D012878 Skin Neoplasms Arsenic 6.4217029826 17050553 17976673 19538983 16251483 15504454
MESH:D012878 Skin Neoplasms Doxorubicin 6.4215692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9316767912 15625365 17203757
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5816010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.6917306315 11144890 19429237 15987713 18640142 19322015 17976673
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.6917653716
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
MESH:D014652 Vascular Diseases Arsenic 5.1317056641
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5817638931 17334414 16364871 17678736
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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