AutismKB 2.0

Annotation Detail for IL1RL1


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Basic Information Top
Gene Symbol:IL1RL1 ( DER4,FIT-1,IL33R,MGC32623,ST2,ST2L,ST2V,T1 )
Gene Full Name: interleukin 1 receptor-like 1
Band: 2q12.1
Quick LinksEntrez ID:9173; OMIM: 601203; Uniprot ID:ILRL1_HUMAN; ENSEMBL ID: ENSG00000115602; HGNC ID: 5998
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2074Asthma
2111Systemic infection
2193Helicobacter infection
2220Dermatitis
Desease Name
HEMATOLOGICAL
plasma eosinophil count
Celiac Disease
IMMUNE
Desease Name
Celiac disease
Plasma eosinophil count
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IL1RL1 mRNAdecreases expression 19933214
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of IL1RL1 mRNAincreases expression 20713471
D000082 Acetaminophen Acetaminophen affects the expression of IL1RL1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IL1RL1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic affects the expression of IL1RL1 mRNAaffects expression 18315880
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IL1RL1 mRNAincreases expression 20713471
D002251 Carbon Tetrachloride IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]affects reaction|increases expression 17412915
D002251 Carbon Tetrachloride IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL13 protein]affects reaction|increases expression 17412915
D002251 Carbon Tetrachloride IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]affects reaction|increases expression 17412915
D002251 Carbon Tetrachloride IL1RL1 protein affects the reaction [Carbon Tetrachloride results in increased expression of IL5 protein]affects reaction|increases expression 17412915
D002713 Chlorine Chlorine results in decreased expression of IL1RL1 mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of IL1RL1 mRNAaffects cotreatment|decreases expression 18636392
D003345 Corticosterone Corticosterone results in decreased expression of IL1RL1 mRNAdecreases expression 15755911
D016572 Cyclosporine Cyclosporine results in increased expression of IL1RL1 mRNAincreases expression 20106945
D015084 2,4-Dichlorophenoxyacetic Acid 2,4-Dichlorophenoxyacetic Acid results in decreased expression of IL1RL1 mRNAdecreases expression 15878651
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IL1RL1 mRNAaffects cotreatment|decreases expression 16054899
D002117 Calcitriol Calcitriol results in increased expression of IL1RL1 mRNAincreases expression 16002434
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of IL1RL1 mRNAincreases expression 11708898
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of IL1RL1 mRNAaffects cotreatment|increases expression 17404688
D005419 Flavonoids Flavonoids results in increased expression of IL1RL1 mRNAincreases expression 18035473
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IL1RL1 mRNAaffects cotreatment|decreases expression 16054899
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of IL1RL1 mRNAincreases expression 20713471
D009151 Mustard Gas Mustard Gas results in increased expression of IL1RL1 mRNAincreases expression 18955075
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of IL1RL1 mRNAaffects cotreatment|decreases expression 18636392
D010126 Ozone Ozone results in increased expression of IL1RL1 mRNAincreases expression 16716893
C008776 pelargonic acid pelargonic acid results in increased expression of IL1RL1 mRNAincreases expression 11379042
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL1RL1 mRNAaffects binding|decreases expression|increases activity 19710929
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of IL1RL1 mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of IL1RL1 mRNAincreases expression 17404688
D011794 Quercetin Quercetin affects the expression of IL1RL1 mRNAaffects expression 18178720
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of IL1RL1 mRNAaffects cotreatment|decreases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IL1RL1 mRNAdecreases expression 19933214
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of IL1RL1 mRNAdecreases expression 11379042
C015559 trimellitic anhydride trimellitic anhydride results in increased expression of IL1RL1 mRNAincreases expression 11708898
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of IL1RL1 mRNAincreases expression 17982090
D001335 Vehicle Emissions Vehicle Emissions results in increased expression of IL1RL1 mRNAincreases expression 19465080
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2818287403
MESH:D055371 Acute Lung Injury Chlorine 8.2920601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.2918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.0320127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.0311473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.336695378
MESH:D000236 Adenoma Methylcholanthrene 6.336695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9716835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.9317306315
MESH:D000382 Agricultural Workers' Diseases 2,4-Dichlorophenoxyacetic Acid 4.8416132792
MESH:D000544 Alzheimer Disease Ozone 4.2615513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.2619621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9917084956
MESH:D000799 Angioedema Acetaminophen 3.5610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8019183758
MESH:D020261 Arsenic Poisoning Arsenic 2.7916251483 12569548 16835338 18414634
MESH:D001169 Arthritis, Experimental Dexamethasone 3.3717659584
MESH:D001172 Arthritis, Rheumatoid Ozone 2.4915570426
MESH:D001249 Asthma marker/mechanism 19198610 21150878
MESH:D001249 Asthma Mustard Gas 10.6910378619
MESH:D001249 Asthma Ozone 10.6917854713 16373670
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 10.6915590890 11742282 17015710 12762349 18394133 12585506 7684630 8156442 170078 6091946 15590891 12684321 19187332 6091945 3040596 16210060 10934080 10797510 11467998 20032816 15855793 16792590 11077013
MESH:D001249 Asthma trimellitic anhydride 10.6916141432
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7015336622
MESH:D050197 Atherosclerosis Arsenic 6.4119371607 12928151
MESH:D050197 Atherosclerosis Methylcholanthrene 6.4111922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Quercetin 4.1319761891
MESH:D001768 Blister Mustard Gas 4.8819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.9419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.9412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0517868700
MESH:D001930 Brain Injuries Progesterone 3.9815380490 15665606 15845082
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 5.5411921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 5.5417474063 20146248
MESH:D001943 Breast Neoplasms Calcitriol 5.5411237771
MESH:D001943 Breast Neoplasms Estradiol 5.5412948864 16675129 17289903 14630087 18497071 19861407 17261762 17018787
MESH:D001943 Breast Neoplasms Methylcholanthrene 5.5417474063
MESH:D001943 Breast Neoplasms Progesterone 5.5416175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 5.5418628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.5420435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 5.5411921183
MESH:D016535 Bronchial Hyperreactivity Ozone 8.1918315731 17626835 18417511 19059883 15516495 14754758 16777450
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 8.1915590891 8156442 12507178
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6917687719 10378619
MESH:D002100 Cachexia Ozone 4.4616183385
MESH:D002105 Cadmium Poisoning Quercetin 5.2616962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5116192424 15721981 18705752 15700767 3786805 15673190 10355542 16227642 16050911 16097048 16011737 16124888
MESH:D002277 Carcinoma Methylcholanthrene 7.6110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4415504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.353084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.3517306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.3518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.3516924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 8.3519519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6817234771
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.1015504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.1020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.1011237771
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.8418640142
MESH:D006332 Cardiomegaly Quercetin 6.2919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2918670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.2615738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.0818022660 16973168
MESH:D002386 Cataract Acetaminophen 2.4210977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.1412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.1418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 10.1416192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D002779 Cholestasis Cyclosporine 7.0819486331
MESH:D002779 Cholestasis pirinixic acid 7.0819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9912621046 8697196 16354765 15668235 15340226
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 4.2718200517 17936198 11698051 17991707 16782535 16867261 16804969 18023891 16474422
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 6.1917373747 19159591
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 6.1917276891
MESH:D003110 Colonic Neoplasms Dexamethasone 3.8115824018
MESH:D003110 Colonic Neoplasms Quercetin 3.8111134977 19440933 15741050 19056647 17148506 16640504 17191121
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8314669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5317728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5310048152 20055451 15322242
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 10.3512438553
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 10.3515491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 10.3512956900 15491423 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 4.5317010967
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0717446233
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5119496084
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 4.2512642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2217187935
MESH:D003967 Diarrhea Dexamethasone 3.447237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.6219085960 12392966 17906064 14550746 14986274 19923254 19739265 19420014 11287661 15619225 10915739 17562736 18071297 10774834 11461765 2444490 11834606 16485898 16227642 16393943 14725611 11739529 16781746 12153990 16081117 12594235 12705907 11743745 12958197 10663392 16177239 19164858 19416960 11529661 16109766 19370779 17522070 18713872 15968718 12540782 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.626884620 2869522 10092053 17522070 6623471 9327722 7120509 4309450 7179309 16227642 15027814 7440962 19336974 10915739 11566570 16177239 15998439 15968718 3732212 19085960 3786805 21278145
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.6220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004417 Dyspnea Chlorine 4.3420016425
MESH:D004485 Eczema Dexamethasone 4.1912438553
MESH:D004487 Edema Dexamethasone 19.0219703484
MESH:D004487 Edema Mustard Gas 19.029260866 11428631 11402378 11428647
MESH:D004487 Edema pirinixic acid 19.0212083418
MESH:D004487 Edema rosiglitazone 19.0212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 19.0212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 8.4315138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.4317692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.8011473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 8.1316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.139294722 10568697
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 4.388156442
MESH:D004890 Erythema Mustard Gas 4.889357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.4718447907
MESH:D005234 Fatty Liver Carbon Tetrachloride 16.7412795759 16045604 15959796 16239168 12631006 61145 19224547 17595544
MESH:D005234 Fatty Liver Cyclosporine 16.7419224547
MESH:D005234 Fatty Liver pirinixic acid 16.7419236843 20131406
MESH:D005234 Fatty Liver rosiglitazone 16.7419196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6610962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 24.8318705752
MESH:D005355 Fibrosis Cyclosporine 24.8312639820 12168785
MESH:D005355 Fibrosis Quercetin 24.8319474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.8320067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 24.8317994277
MESH:D005534 Foot Diseases Arsenic 5.276392382
MESH:D005739 Gas Poisoning Chlorine 4.7320016425
MESH:D005756 Gastritis Acetaminophen 3.3916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.948708960
MESH:D005909 Glioblastoma Quercetin 3.2119804834
MESH:D005910 Glioma Quercetin 2.9417643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3319110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 7.3518467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3515340226 16120746 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.977520565
MESH:D006558 Herpes Genitalis Estradiol 4.7515709030
MESH:D019584 Hot Flashes Estradiol 3.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.1616870215
MESH:D006930 Hyperalgesia rosiglitazone 7.1612083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2516899240
MESH:D006943 Hyperglycemia pirinixic acid 8.4420558911
MESH:D006943 Hyperglycemia Quercetin 8.4418262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2117050553
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.3610880147 11019492
MESH:D006973 Hypertension Arsenic 15.2316076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 15.2310903974
MESH:D006973 Hypertension Dexamethasone 15.2317042910
MESH:D006973 Hypertension Quercetin 15.2318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 15.2318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8115338365
MESH:D006987 Hypesthesia Arsenic 5.2716093927
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1618306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1315869954
MESH:D007248 Infertility, Male 2,4-Dichlorophenoxyacetic Acid 4.4212948887
MESH:D007249 Inflammation Dexamethasone 18.078960868 11099482
MESH:D007249 Inflammation Flavonoids 18.0717296493
MESH:D007249 Inflammation Mustard Gas 18.0716001271 11428620 11428631 9260866 11428647 8975870 9357497 17524151 11402378
MESH:D007249 Inflammation Progesterone 18.0715869954
MESH:D007249 Inflammation rosiglitazone 18.0712083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.0712200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.4718200517
MESH:D007251 Influenza, Human Quercetin 4.2216624496
MESH:D007333 Insulin Resistance Estradiol 11.3416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.3416306350
MESH:D007333 Insulin Resistance rosiglitazone 11.3416306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.3317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0916580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1618306037
MESH:D007627 Keloid Quercetin 4.6817086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1615604871
MESH:D007642 Keratosis Arsenic 4.7112749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 13.1012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.1018776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 13.1015618244
MESH:D007674 Kidney Diseases Quercetin 13.1016962696
MESH:D007680 Kidney Neoplasms Cyclosporine 6.5312371664
MESH:D007680 Kidney Neoplasms Estradiol 6.5315610895
MESH:D007938 Leukemia Quercetin 3.0217468513
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.3717339181
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6611408273 21278145 16943688 17157831 16221502 16239168 17174718 11903743 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.3418279442 15730626 15959796 18472094 16027843 17922224 17944888 18210741 12741479 15818738 15123356 14620537 18429990 12546737 12632512 16248980 18156304 17481882 18187930 18054572 12586293 12898905 17766677 17869086 14724832 18376398 18263696 15673190 14716833 18251166 18418968 14716496 16011737 17565644 15362042 18472332 17525996 12389079 17900296 18412020 12667390 16638106 12445421 17761835 17976157 14748882 17640975 17698563 15876570 15925388 16097048 12666154 18395095 16015684 12609069 18395914 16033810 18317297 18420326 15338365 18205269 17805973 13678700 16136751 16192424 17823541 20821823 18006644 18705752 12632514 17631135 15931870 15057751 12649538 18481824 18277467 15996030 12445418 11481614 16116963 18166357 15370692 12958196 17557913 10355542 17708605 18339082 14512876 17721639 17714472 15650968 15893842 15052691
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 10.3416718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.3414659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.3415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.3412741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 10.3415980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.3412878042
MESH:D008107 Liver Diseases Acetaminophen 6.0819014921 11587558 19784758 16610002 19460945 12587719 12969438 16611625
MESH:D008107 Liver Diseases Arsenic 6.0811134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.0816964402 15720792 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.6116899240 14706259
MESH:D008113 Liver Neoplasms Arsenic 16.5616368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.5621137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.5619294768
MESH:D008113 Liver Neoplasms pirinixic acid 16.5616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 16.5618980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.5616984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 12.7312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 12.731399818 598648
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.7319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.7312151625
MESH:D008171 Lung Diseases Mustard Gas 7.0018702808 18161513
MESH:D008171 Lung Diseases Ozone 7.0019066396 8266340
MESH:D055370 Lung Injury Ozone 3.5820417186
MESH:D008175 Lung Neoplasms Arsenic 14.6817306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.6818569708 20064080 18816296 18520028 20464547 20869020 6695378 17053015 20135361
MESH:D008175 Lung Neoplasms Dexamethasone 14.6811195469 15824018
MESH:D008175 Lung Neoplasms Methylcholanthrene 14.6816337739 17909032 16271038 10545420 9230183 20512841 15390079 6695378 1399818 21163286 7750092 11893704 20970405
MESH:D008175 Lung Neoplasms Mustard Gas 14.688781369 3148597
MESH:D008175 Lung Neoplasms Ozone 14.687614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 14.6816280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.6811884234 19555203
MESH:D008175 Lung Neoplasms Vehicle Emissions 14.689255578
MESH:D008228 Lymphoma, Non-Hodgkin 2,4-Dichlorophenoxyacetic Acid 4.9316132792
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 16.9711921183
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 16.9712807724
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.9711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 16.9711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 16.9716827153
MESH:D020149 Manganese Poisoning Estradiol 4.2019453300
MESH:D008545 Melanoma Dinitrochlorobenzene 3.1617334785 12202904
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2919513568
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1517261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5016801185
MESH:D008679 Metaplasia Ozone 4.8210496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9816381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.3116118317 15867202 15744524
MESH:D009135 Muscular Diseases pirinixic acid 3.2316239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.389809623
MESH:D009203 Myocardial Infarction pirinixic acid 5.3319151258
MESH:D009203 Myocardial Infarction Quercetin 5.3319595682
MESH:D017202 Myocardial Ischemia Arsenic 8.2715371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.9616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.9616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.9619207477
MESH:D009369 Neoplasms Benzo(a)pyrene 7.4311141357
MESH:D009369 Neoplasms pirinixic acid 7.4317405874
MESH:D009369 Neoplasms Quercetin 7.4315185748
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.461670384
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.5816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5814600291
MESH:D009436 Neural Tube Defects Arsenic 3.2716620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6518514411
MESH:D020078 Neurogenic Inflammation Arsenic 9.8317056641
MESH:D020078 Neurogenic Inflammation Quercetin 9.8317929310
MESH:D009503 Neutropenia Mustard Gas 3.7116761898 7688884
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.483040596 6091945 18394133 6091946 12585506 8156442 11077013
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.9619495926
MESH:D010051 Ovarian Neoplasms Arsenic 10.5717306315
MESH:D010051 Ovarian Neoplasms Estradiol 10.5719401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.5717393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 10.5719005980
MESH:D010146 Pain Acetaminophen 2.1716870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.7516965848
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.9517698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.7116905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 3.8616369182
MESH:D011014 Pneumonia Ozone 4.1218381685 18929643 18007984
MESH:D011041 Poisoning Mustard Gas 3.5415727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3312371664
MESH:D011230 Precancerous Conditions Quercetin 8.3319056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3921297632
MESH:D011248 Pregnancy Complications 2,4-Dichlorophenoxyacetic Acid 5.452087686
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9111896295 11399792 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5015572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6320887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8918247401 12479363 15754350 16644109 16289102
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Quercetin 1.8917292933 14715546
MESH:D011507 Proteinuria Arsenic 3.7521343184
MESH:D011537 Pruritus Mustard Gas 3.8118058305
MESH:D011565 Psoriasis Cyclosporine 2.1316882103
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.3414606601
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8217894541 17620002 17266442 10334151 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 2.2519058328
MESH:D012120 Respiration Disorders Chlorine 4.9318579056
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.7611700416 18379247
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 8.4420219652 7692837 16940033
MESH:D012130 Respiratory Hypersensitivity trimellitic anhydride 8.4420219652
MESH:D012135 Respiratory Sounds Vehicle Emissions 4.9418950799
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.8418447907
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.3419050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 4.9912617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.2319075512
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.2616862918
MESH:D012871 Skin Diseases Arsenic 4.8817938729 18709164 17548696 16759981 17453740 6392382 19834688 16702368 17050553 15952646 16353154
MESH:D012871 Skin Diseases Mustard Gas 4.8816961503 12880345 15451306
MESH:D012878 Skin Neoplasms Arsenic 8.6717050553 17976673 16251483 17029826 19538983 15504454
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.6716192470
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.2319050374 19075512
MESH:D013119 Spinal Cord Injuries Progesterone 4.0015862959 16503802
MESH:D013272 Stomach Diseases Dexamethasone 4.0415472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5520155912 2093021
MESH:D013276 Stomach Ulcer Dexamethasone 3.2515138204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6212697716
MESH:D013978 Tibial Fractures Estradiol 4.4019048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.1118640142 19322015 19429237 11144890 17306315 17976673 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.1117053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 11.1116720314
MESH:D001749 Urinary Bladder Neoplasms Vehicle Emissions 11.1111144890
MESH:D014581 Urticaria Acetaminophen 2.7210982225
MESH:D014605 Uveitis Cyclosporine 10.821336536
MESH:D014605 Uveitis Dexamethasone 10.821336536
MESH:D014652 Vascular Diseases Arsenic 4.4617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29814
    • No data
    Releated disease ID Related disease Name
    PA443879Dermatitis, Atopic
    PA443450Asthma
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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