AutismKB 2.0

Annotation Detail for YTHDC1


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Basic Information Top
Gene Symbol:YTHDC1 ( KIAA1966,YT521,YT521-B )
Gene Full Name: YTH domain containing 1
Band: 4q13.2
Quick LinksEntrez ID:91746; OMIM: NA; Uniprot ID:YTDC1_HUMAN; ENSEMBL ID: ENSG00000083896; HGNC ID: 30626
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of YTHDC1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of YTHDC1 mRNAaffects expression 17562736
D006710 Homocysteine Homocysteine results in decreased expression of YTHDC1 mRNAdecreases expression 17326132
D000643 Ammonium Chloride Ammonium Chloride affects the expression of YTHDC1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of YTHDC1 mRNAincreases expression 20458559
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of YTHDC1 mRNAincreases expression 18687144
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of YTHDC1 mRNAincreases expression 17616710
D018038 Sodium Selenite Sodium Selenite results in increased expression of YTHDC1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of YTHDC1 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3319825857 11798837
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001321 Autistic Disorder Acetaminophen 2.2418445737
MESH:D001321 Autistic Disorder Homocysteine 2.2420468076 16297937
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.6616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5511589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.6916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6915073043 14691202 11135700 16217749 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.3112490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.188697196 15340226 12621046 16354765 15668235
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D003324 Coronary Artery Disease Homocysteine 3.8216379339
MESH:D023903 Coronary Restenosis arsenic trioxide 4.4212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5220055451 15322242 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.2718551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.3215213294
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.4018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4016109766 11461765 16081117 19923254 16485898 18071297 19164858 2444490 16177239 11743745 17562736 12705907 17522070 19416960 14986274 14550746 12594235 11529661 19085960 19739265 11421492 10663392 19370779 12392966 11834606 12153990 16393943 12540782 15968718 15619225 16227642 14725611 17906064 12958197 19420014 10774834 11287661 16781746 18713872 11739529 10915739
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.4015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.8712903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.8715878914 16805852 15623463 15150132 16704527 15547733 15264214 15547721 16510608
MESH:D017889 Exfoliation Syndrome Homocysteine 5.9916504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver arsenic trioxide 3.4915073043
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.5016904648
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005901 Glaucoma Homocysteine 5.5116504073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Homocysteine 7.2719638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.2711294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1516120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.368697196 18606429 16354765 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.8918234410 17369066 17292331
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9718850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3015629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.1416705839
MESH:D007938 Leukemia arsenic trioxide 2.9215070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.0012560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1620471514 19850784 16467208 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3416331271 16891316 9834237 19225113 11468182 16966277 15336539 15622746 16112521 17869043 17217047 16330433 19035177 16823087 17712046 15213294 15748426 17649720 19642359 11161223 12712474 12679006 19075265 12018890 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5916882451
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 12587719 11587558 16611625 19460945 19784758 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 4.6614682389
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.2120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.5115213294
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2817365036
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3419825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3411884234 19555203
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008591 Meningomyelocele Homocysteine 5.7916602021
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2518303189 16966607 16166281
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2515949261 19549372 14977855 11468182 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2516882451 16105982
MESH:D009203 Myocardial Infarction Homocysteine 3.7917412321
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.1418551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.2016624393
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2410525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.6216049721 12819281
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4616624393 12452020 19769630
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D010235 Paraganglioma arsenic trioxide 4.3819927285
MESH:D010300 Parkinson Disease Homocysteine 3.6316275827
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1510923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2919131511
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2918760546
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0917975199 17322281 15814490 17365031
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.2016646077
MESH:D012559 Schizophrenia Homocysteine 3.1316641680
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6618551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6917007042
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6917575124 12958204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2419014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2415213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.3116049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3120435036 12973940 11780464 12845720
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.6010091137
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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