AutismKB 2.0

Annotation Detail for MAP3K13


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP3K13 ( LZK,MEKK13,MGC133196 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 13
Band: 3q27.2
Quick LinksEntrez ID:9175; OMIM: 604915; Uniprot ID:M3K13_HUMAN; ENSEMBL ID: ENSG00000073803; HGNC ID: 6852
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
No data
Pathway IDPathway Name
200161Signaling events mediated by VEGFR1 and VEGFR2
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MAP3K13 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MAP3K13 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of MAP3K13 mRNAdecreases expression 20106945
C006253 pirinixic acid pirinixic acid results in increased expression of MAP3K13 mRNAincreases expression 18301758
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of MAP3K13 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Zinc Sulfate 5.457265320
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D000860 Anoxia Zinc Sulfate 5.567265320
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.023084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.0212907637 12619106 21507988
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7612371664
MESH:D002779 Cholestasis Cyclosporine 8.6319486331
MESH:D002779 Cholestasis pirinixic acid 8.6319176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6616485898 11421492 15619225 11739529 2444490 14725611 10774834 11834606 14986274 12958197 19164858 17906064 12540782 11461765 19420014 18071297 19923254 11287661 12594235 10915739 12392966 12705907 10663392 15968718 16393943 16177239 12153990 19739265 18713872 16081117 19370779 16227642 17562736 16781746 14550746 19085960 11529661 17522070 11743745 16109766 19416960
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D005234 Fatty Liver Cyclosporine 8.8219224547
MESH:D005234 Fatty Liver pirinixic acid 8.8219236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.4817063115
MESH:D006529 Hepatomegaly pirinixic acid 3.4818467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007022 Hypotension Zinc Sulfate 4.877265320
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.418314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0412371664
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.5715237267
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 19460945 12587719 19014921 11587558 19784758 16610002 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.859163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms pirinixic acid 4.8516377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.948603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6118481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
Pathway ID Pathway Name
KEGG:04010 MAPK signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30596
    • No data
    No data
    Releated drug ID Related drug Name
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved