AutismKB 2.0

Annotation Detail for OSMR


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Basic Information Top
Gene Symbol:OSMR ( MGC150626,MGC150627,MGC75127,OSMRB )
Gene Full Name: oncostatin M receptor
Band: 5p13.1
Quick LinksEntrez ID:9180; OMIM: 601743; Uniprot ID:OSMR_HUMAN; ENSEMBL ID: ENSG00000145623; HGNC ID: 8507
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
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No data
Related Diseases/Disorders Top
No data
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Desease Name
Amyloidosis, primary localized cutaneous
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of OSMR mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of OSMR mRNAincreases expression 19420014
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of OSMR proteinaffects expression 20106945
D001151 Arsenic Arsenic results in decreased expression of OSMR mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of OSMR mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OSMR mRNAdecreases expression 20018196
19150397
C459604 candoxin candoxin results in decreased expression of OSMR mRNAdecreases expression 16309724
D002251 Carbon Tetrachloride OSMR protein affects the reaction [Carbon Tetrachloride results in increased activity of MMP9 protein]affects reaction|increases activity 14999682
D002251 Carbon Tetrachloride OSMR protein affects the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]affects reaction|increases expression 14999682
D002251 Carbon Tetrachloride OSMR protein affects the reaction [Carbon Tetrachloride results in increased expression of TIMP2 mRNA]affects reaction|increases expression 14999682
D003474 Curcumin Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OSMR mRNA]decreases reaction|increases expression 18200517
D016572 Cyclosporine Cyclosporine results in increased expression of OSMR mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of OSMR mRNAincreases expression 15251184
C014347 decitabine [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of OSMR mRNAaffects cotreatment|increases expression 15251184
D004041 Dietary Fats Dietary Fats results in decreased expression of OSMR mRNAdecreases expression 18042831
C025034 doxifluridine OSMR protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli results in increased expression of OSMR mRNAincreases expression 15919760
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of OSMR mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of OSMR mRNAincreases expression 19619570
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of OSMR mRNAincreases expression 15743783
C419708 gefitinib OSMR protein affects the susceptibility to gefitinibaffects response to substance 15496427
C051890 irinotecan irinotecan metabolite results in increased expression of OSMR mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of OSMR mRNAincreases expression 15956246
C051890 irinotecan OSMR protein results in decreased susceptibility to irinotecandecreases response to substance 16734730
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of OSMR mRNAincreases expression 15919760
D017239 Paclitaxel OSMR protein results in increased susceptibility to Paclitaxelincreases response to substance 16734730
C041786 palm oil palm oil results in decreased expression of OSMR mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OSMR mRNAaffects binding|decreases expression|increases activity 19710929
D013629 Tamoxifen Tamoxifen affects the expression of OSMR mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of OSMR mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of OSMR mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of OSMR mRNAaffects cotreatment|increases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of OSMR mRNAincreases expression 15251184
D014302 Trinitrobenzenesulfonic Acid Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of OSMR mRNA]decreases reaction|increases expression 18200517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of OSMR mRNAincreases expression 17982090
18200517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3814745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6811752688 14514962 15322242
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.5111850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.5118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1420127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.1411473722
MESH:D000236 Adenoma 2-Acetylaminofluorene 6.6310737359
MESH:D000236 Adenoma Benzo(a)pyrene 6.636695378
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.846705139
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.0417306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.9117887948
MESH:D000544 Alzheimer Disease Curcumin 2.5815590663
OMIM:105250 AMYLOIDOSIS, PRIMARY LOCALIZED CUTANEOUS, 1 marker/mechanism
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D000799 Angioedema Acetaminophen 3.6710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9019183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8218414634 16835338 16251483 12569548
MESH:D001161 Arteriosclerosis Dietary Fats 3.7215238619
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7016807698
MESH:D050197 Atherosclerosis Arsenic 6.5719371607 12928151
MESH:D050197 Atherosclerosis Curcumin 6.5718704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases Curcumin 4.3219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.2519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.4115867366
MESH:D002545 Brain Ischemia Curcumin 4.1616770732
MESH:D001932 Brain Neoplasms Curcumin 3.7917596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6017474063 20146248
MESH:D001943 Breast Neoplasms Curcumin 4.6019250217 18462866 18593918 16243823
MESH:D001943 Breast Neoplasms decitabine 4.6018320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 4.6020435547
MESH:D001943 Breast Neoplasms Estradiol 4.6012948864 17018787 16675129 17289903 14630087 18497071 17261762 19861407
MESH:D001943 Breast Neoplasms Paclitaxel 4.6016273361 18223236 16244791 18234424 15136595 11325840 18323546 16115903
MESH:D001943 Breast Neoplasms Tamoxifen 4.6018815881 18997820 16202921 20065188 19084267 19288272 19189212 19103187 19155303 17440819 19115204 18425577 16273361 19487384 17242785 15668708 20544844 20005174 20135344 19289846 19059307 18984771 19189210 18821012 19221464 20859285 18351453 20390343 15565566 19066611 19244106 16873071 18855134 19410462 11161223 19011961 17893378 19200415 16818667 17049068 18629630 17261762 19142967 21152245 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.613786805 15721981 15673190 18705752 16050911 15700767 16192424 10355542 16227642 16011737 16124888 16097048
MESH:D002277 Carcinoma Curcumin 7.8318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5015504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3419066611
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 16.4517761372 6705139 3581430 3084413 10737359
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.453084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.4512907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 16.4516507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.4518788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.4516924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 16.4516313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 16.4516924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung marker/mechanism 15496427
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 5.9218414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 5.9217290066 20005069 19233551 15496427 16230376 18347146
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.4218922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.4220419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 10.4218462866
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.4219215824
MESH:D002295 Carcinoma, Transitional Cell Arsenic 9.0018640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.0017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2718670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.3315738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.1618022660 16973168
MESH:D002386 Cataract Acetaminophen 2.4810977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.4620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.4612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.4618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis Cyclosporine 7.3419486331
MESH:D002779 Cholestasis pirinixic acid 7.3419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0315668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Curcumin 9.3816804969 16782535 18200517
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.3816782535 16867261 16474422 17936198 18200517 17991707 18023891 11698051 16804969
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.3917276891
MESH:D003103 Coloboma Curcumin 4.3918809619
MESH:D003110 Colonic Neoplasms Curcumin 5.7719359593 16340194
MESH:D003110 Colonic Neoplasms decitabine 5.7717616700
MESH:D003110 Colonic Neoplasms irinotecan 5.7717725105 17287894
MESH:D015179 Colorectal Neoplasms decitabine 4.7818981723
MESH:D015179 Colorectal Neoplasms gefitinib 4.7817594712
MESH:D015179 Colorectal Neoplasms irinotecan 4.7818259882 17454858 16391804 18509181 17159606 15273666 16303861
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.7818802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.7318497527
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1919031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.2718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2717107852
MESH:D003928 Diabetic Nephropathies Curcumin 14.1918204486
MESH:D003928 Diabetic Nephropathies Estradiol 14.1919279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.1919279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.8216781746 2444490 12392966 17522070 12594235 16081117 19164858 12705907 12540782 11287661 19420014 19923254 11461765 19739265 19370779 12958197 11743745 15619225 11529661 16109766 12153990 11834606 16485898 19085960 14725611 15968718 10774834 16227642 11739529 17906064 18713872 11421492 14550746 14986274 17562736 18071297 10663392 16177239 16393943 10915739 19416960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.8215027814 3732212 6884620 15998439 9327722 7120509 2869522 11566570 10092053 17522070 21278145 7179309 19085960 6623471 7440962 4309450 16177239 3786805 10915739 15968718 16227642 19336974
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.8220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6311462148
MESH:D004381 Duodenal Ulcer Curcumin 3.8817351913
MESH:D050171 Dyslipidemias Dietary Fats 3.3318367378
MESH:D004487 Edema pirinixic acid 6.0312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7318230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.3719031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9419294695
MESH:D016889 Endometrial Neoplasms Estradiol 7.0218566989 19148513 11473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.0219155303 20544844 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8710568697 9294722
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 10.4718509659 17637181
MESH:D019446 Endotoxemia Lipopolysaccharides 10.4717637181 15821434 15328337
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.0220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0216530937
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.0216481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.6912631006 17595544 12795759 16239168 61145 16045604 19224547 15959796
MESH:D005234 Fatty Liver Curcumin 28.6919297423
MESH:D005234 Fatty Liver Cyclosporine 28.6919224547
MESH:D005234 Fatty Liver Dietary Fats 28.6918296743 19551842 17967931 19004024
MESH:D005234 Fatty Liver pirinixic acid 28.6919236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 28.6914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005334 Fever endotoxin, Escherichia coli 9.2516997862
MESH:D005334 Fever Lipopolysaccharides 9.259205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3514745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0119069698
MESH:D005355 Fibrosis Carbon Tetrachloride 32.3118705752
MESH:D005355 Fibrosis Curcumin 32.3118705752
MESH:D005355 Fibrosis Cyclosporine 32.3112168785 12639820
MESH:D005355 Fibrosis Dietary Fats 32.3118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 32.3120067830
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 32.3117994277
MESH:D005534 Foot Diseases Arsenic 5.396392382
MESH:D005756 Gastritis Acetaminophen 3.5016983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.5218462866
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.058708960
MESH:D005909 Glioblastoma Curcumin 3.3717596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.6218829502 18462866
MESH:D006258 Head and Neck Neoplasms decitabine 7.6219215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4320558911
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 5.146705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.256705139
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2515720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.7019772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7015340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.8717701891
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D019584 Hot Flashes Estradiol 3.5817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.878697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.5716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3616899240
MESH:D006937 Hypercholesterolemia Curcumin 8.7118704882
MESH:D006937 Hypercholesterolemia Dietary Fats 8.7121332399
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.3017050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.4521332399
MESH:D006973 Hypertension Arsenic 8.209931084 16076760 11953799
MESH:D006973 Hypertension Cyclosporine 8.2010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9215338365
MESH:D006976 Hypertension, Pulmonary gefitinib 4.5718424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.0618424623
MESH:D006987 Hypesthesia Arsenic 5.3916093927
MESH:D007248 Infertility, Male decitabine 3.0917581917
MESH:D007249 Inflammation Curcumin 14.9318403477 17151092 16956363
MESH:D007249 Inflammation Dietary Fats 14.9320412841
MESH:D007249 Inflammation Lipopolysaccharides 14.939205823 17963957 12878042 17255318 17237260
MESH:D007249 Inflammation Tamoxifen 14.9319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.9312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 6.4618596194 18200517
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 6.4618200517
MESH:D007333 Insulin Resistance Dietary Fats 11.6518457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.6516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.6516306350
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 4.4417994277
MESH:D007414 Intestinal Neoplasms Curcumin 4.0710783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4717255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2715604871
MESH:D007642 Keratosis Arsenic 4.8212749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.418314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.4115618244
MESH:D007680 Kidney Neoplasms Cyclosporine 16.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 16.6715610895
MESH:D007680 Kidney Neoplasms gefitinib 16.6718625569
MESH:D007680 Kidney Neoplasms Tamoxifen 16.6718625569
MESH:D007889 Leiomyoma Curcumin 4.4118555241
MESH:D007938 Leukemia Curcumin 6.3218462866
MESH:D007938 Leukemia decitabine 6.3218980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.0516106398
MESH:D007951 Leukemia, Myeloid decitabine 3.8517236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3518460780 18206229 17679729 19387464 19010910 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2918055864
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.4417339181
MESH:D015458 Leukemia, T-Cell Curcumin 4.6016106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.5315821434
MESH:D008064 Lipidoses Tamoxifen 3.0317567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.6617353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3211408273 11903743 16943688 21278145 16221502 17174718 17334410 16239168 17157831
MESH:D008103 Liver Cirrhosis Dietary Fats 6.3218296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5915893842 15370692 18420326 15673190 18429990 15338365 18279442 14512876 17565644 12667390 15052691 18376398 16192424 17525996 12632512 15876570 17631135 18156304 16116963 17823541 18395095 18251166 18705752 17557913 15057751 18472094 18317297 16015684 17944888 16136751 14716833 18210741 15362042 15730626 18339082 18412020 18277467 18418968 17922224 12632514 16638106 15818738 17976157 17761835 15959796 18395914 18481824 17481882 17766677 17869086 15123356 18472332 17900296 14620537 16033810 12958196 12586293 17640975 20821823 13678700 12741479 17805973 18263696 15925388 11481614 16248980 18205269 14716496 16027843 14748882 16011737 17714472 15996030 17698563 18166357 12666154 12609069 17708605 18187930 18006644 14724832 18054572 12649538 12546737 16097048 12445421 15931870 12389079 10355542 12898905 15650968 12445418 17721639
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 10.5917355460 18705752 18006644
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.5914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 10.5912878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.5915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.5918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.5912878042
MESH:D008107 Liver Diseases Acetaminophen 9.0419014921 12969438 16610002 19784758 12587719 16611625 19460945 11587558
MESH:D008107 Liver Diseases Arsenic 9.0411134558
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.0416964402 15830285 15720792 16246199 17285989
MESH:D008107 Liver Diseases Curcumin 9.0416956363
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9915123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9116899240 14706259
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 24.8416273603 14678523 10737359 11376686 18001218 10672840
MESH:D008113 Liver Neoplasms Aflatoxin B1 24.8415890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Arsenic 24.8416368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 24.8420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 24.8419294768
MESH:D008113 Liver Neoplasms pirinixic acid 24.8416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 24.8416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 24.8416984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 13.286150874 534488 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.288603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.2815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.2812151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.8421114838
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 10.3811376686
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.3814755239
MESH:D008175 Lung Neoplasms Arsenic 10.3817976673 19168569 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.3818816296 20464547 20135361 18569708 20064080 17053015 20869020 18520028 6695378
MESH:D008175 Lung Neoplasms Curcumin 10.3816243823 19359593 18462866
MESH:D008175 Lung Neoplasms Tamoxifen 10.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3819555203 11884234
MESH:D008223 Lymphoma Curcumin 7.3718462866
MESH:D008223 Lymphoma decitabine 7.3719470736
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9514749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.5216173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5919428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.5117203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 9.5118375820
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.5116827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.0719453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0719453300
MESH:D008545 Melanoma Curcumin 7.0917885582 18462866
MESH:D008545 Melanoma decitabine 7.0916505122 17785578
MESH:D008545 Melanoma Paclitaxel 7.0912040289 12025231 16342250
MESH:D008545 Melanoma Tamoxifen 7.0919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4019513568
MESH:D008569 Memory Disorders Curcumin 3.9917263510
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0616381670
MESH:D052016 Mucositis irinotecan 4.8417159606
MESH:D009101 Multiple Myeloma Curcumin 11.5619372569
MESH:D009101 Multiple Myeloma decitabine 11.5618172295
MESH:D009101 Multiple Myeloma Paclitaxel 11.5614749477
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.7517962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2919157545 18608210 16882708 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Arsenic 8.5515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8116411023
MESH:D009361 Neoplasm Invasiveness Curcumin 4.2018495463
MESH:D009362 Neoplasm Metastasis irinotecan 9.2518259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.2515867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.2519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7411141357
MESH:D009369 Neoplasms decitabine 7.7417925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 7.7417405874
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 10.2712497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.2719200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.9111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9114600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.4618462866
MESH:D009436 Neural Tube Defects Arsenic 3.3416620997
MESH:D009447 Neuroblastoma irinotecan 3.398761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7318514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.568761367
MESH:D020078 Neurogenic Inflammation Arsenic 4.2117056641
MESH:D009765 Obesity Curcumin 7.1819297423
MESH:D009765 Obesity Dietary Fats 7.1817217161 11836018 18457598 20132043 16723640 18674790 21332399 20518802 19632207
MESH:D009765 Obesity pirinixic acid 7.1820558911
MESH:D010014 Osteolysis Paclitaxel 4.8115867366
MESH:D010024 Osteoporosis Curcumin 3.3718719352
MESH:D010051 Ovarian Neoplasms Arsenic 14.4217306315
MESH:D010051 Ovarian Neoplasms Curcumin 14.4218462866 19020741
MESH:D010051 Ovarian Neoplasms decitabine 14.4219331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 14.4219401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 14.4211161223
MESH:D010146 Pain Acetaminophen 2.2516870215
MESH:D010190 Pancreatic Neoplasms Curcumin 5.3517440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms decitabine 5.3519294695
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.0417698068
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.0116093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.8215371236 16905509 6392382
MESH:D011014 Pneumonia Lipopolysaccharides 4.3812224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0211222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.5617616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.0816140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0817292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.0811398177 18226269 12497104 18769126 10851300 18156803 15129424
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms gefitinib 2.0815651060 16685379 17914592
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0816729912 17172428 17136230 16356831
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011507 Proteinuria Arsenic 3.8421343184
MESH:D011565 Psoriasis Cyclosporine 2.1716882103
MESH:D011656 Pulmonary Emphysema Curcumin 4.3819168576
MESH:D011658 Pulmonary Fibrosis gefitinib 3.9418424623
MESH:D015427 Reperfusion Injury pirinixic acid 2.3019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.8718379247 10666014
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6210835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.2419155313
MESH:D012509 Sarcoma Curcumin 3.9718462866
MESH:D018805 Sepsis Curcumin 3.9318389075
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 5.4618063050
MESH:D012871 Skin Diseases Arsenic 2.7015952646 16759981 18709164 16702368 16353154 6392382 17050553 19834688 17453740 17548696 17938729
MESH:D012878 Skin Neoplasms Arsenic 8.9717976673 15504454 17029826 19538983 16251483 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.9719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.9716192470
MESH:D013088 Spermatocele Tamoxifen 4.1216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8719457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.6420155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.6419037991
MESH:D013274 Stomach Neoplasms irinotecan 4.6415723263
MESH:D013274 Stomach Neoplasms Paclitaxel 4.6418396642 18506536
MESH:D013276 Stomach Ulcer Curcumin 3.3516631530 19188055
MESH:D024801 Tauopathies Paclitaxel 4.6416930453
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0115821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms decitabine 7.4017967635
MESH:D013964 Thyroid Neoplasms gefitinib 7.4016940797
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 19.0315289314 1399818 15867355
MESH:D001749 Urinary Bladder Neoplasms Arsenic 19.0317306315 19429237 11144890 18640142 19322015 15987713 17976673
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 19.0317053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 19.0318593936
MESH:D001749 Urinary Bladder Neoplasms decitabine 19.0317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 19.0316712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 5.0918462866
MESH:D014581 Urticaria Acetaminophen 2.8210982225
MESH:D014604 Uveal Neoplasms decitabine 4.7417785578
MESH:D014605 Uveitis Cyclosporine 3.811336536
MESH:D014652 Vascular Diseases Arsenic 4.5617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
MESH:D015430 Weight Gain Dietary Fats 3.5916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2717120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA32837
    • No data
    Releated disease ID Related disease Name
    PA443331Amyloidosis
    PA447169Amyloidosis, Familial
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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