Annotation Detail for MYLK3
Basic Information Top
| Gene Symbol: | MYLK3 ( MGC126319,MGC126320,MLCK,MLCK2,caMLCK ) |
|---|---|
| Gene Full Name: | myosin light chain kinase 3 |
| Band: | 16q11.2 |
| Quick Links | Entrez ID:91807; OMIM: 612147; Uniprot ID:MYLK3_HUMAN; ENSEMBL ID: ENSG00000140795; HGNC ID: 29826 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| hsa04270 | Vascular smooth muscle contraction |
| hsa04020 | Calcium signaling pathway |
| hsa04971 | Gastric acid secretion |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04510 | Focal adhesion |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| P00016 | Cytoskeletal regulation by Rho GTPase |
| P00031 | Inflammation mediated by chemokine and cytokine signaling pathway |
| No data |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D010656 | Phenylephrine | Phenylephrine results in increased phosphorylation of MYLK3 protein | increases phosphorylation | 18202317 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D001145 | Arrhythmias, Cardiac | Phenylephrine | 4.68 | 17460149 | |
| MESH:D001919 | Bradycardia | Phenylephrine | 5.63 | 15306635 | |
| MESH:D006332 | Cardiomegaly | Phenylephrine | 3.79 | 11179087 15728586 11754973 17124262 17287366 16170337 | |
| MESH:D006973 | Hypertension | Phenylephrine | 3.22 | 12717712 8949925 | |
| MESH:D006984 | Hypertrophy | Phenylephrine | 5.18 | 12791704 18502941 | |
| MESH:D012852 | Sinusitis | Phenylephrine | 5.79 | 7327846 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04020 | Calcium signaling pathway |
| KEGG:04510 | Focal adhesion |
| KEGG:04971 | Gastric acid secretion |
| KEGG:04810 | Regulation of actin cytoskeleton |
| KEGG:04270 | Vascular smooth muscle contraction |