AutismKB 2.0

Annotation Detail for ARHGEF2


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Basic Information Top
Gene Symbol:ARHGEF2 ( DKFZp547L106,DKFZp547P1516,FLJ45440,GEF,GEF-H1,GEFH1,KIAA0651,LFP40,P40 )
Gene Full Name: Rho/Rac guanine nucleotide exchange factor (GEF) 2
Band: 1q22
Quick LinksEntrez ID:9181; OMIM: 607560; Uniprot ID:ARHG2_HUMAN; ENSEMBL ID: ENSG00000116584; HGNC ID: 682
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05130Pathogenic Escherichia coli infection
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Signaling by Rho GTPases
Pathway IDPathway Name
200165Regulation of RAC1 activity
200051Reelin signaling pathway
200050Regulation of RhoA activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001104 Arbutin Arbutin results in decreased expression of ARHGEF2 mRNAdecreases expression 17103032
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ARHGEF2 mRNAaffects cotreatment|increases expression 18164116
C006780 bisphenol A bisphenol A results in decreased expression of ARHGEF2 mRNAdecreases expression 20678512
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of ARHGEF2 mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in increased expression of ARHGEF2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ARHGEF2 mRNAaffects cotreatment|increases expression 18164116
C008493 methylselenic acid methylselenic acid results in increased expression of ARHGEF2 mRNAincreases expression 18548127
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of ARHGEF2 mRNAincreases expression 17951470
D014212 Tretinoin Tretinoin results in increased expression of ARHGEF2 mRNAincreases expression 16054129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma beta-Naphthoflavone 7.2519389873
MESH:D000236 Adenoma Diethylnitrosamine 7.256695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1819061943 19052882 17620307 16434500 17162532 18056438
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.1916412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8116197459 16206674
MESH:D001862 Bone Resorption bisphenol A 4.0711985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9317123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9317474063
MESH:D001943 Breast Neoplasms Tretinoin 1.9316873071 16166294 16443354
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1219052882 20007298 19539802 18506893 16569478 17138121 18210153 11831363 20727157 19171122 19701751 16779866 20214788 17978847 16935385 19519916 3084413 20524982 19208518 17761372 18393292 17173139 16328049 20084675 16502159 19822196 18788625 16288022 17162532 21159647 18056438 18785209 19418558 16807293 18971187 19394651 10672840 18665156 19383236 16540662 16878318 17428255 20512989 16681979 20101231 17055752 3581430 19919837 19335982 16830150 10737359 20432363 16698587 19107877 18494052 20935162 18691550 20514400 18978308
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.121917145
MESH:D002278 Carcinoma in Situ bisphenol A 5.2717123778
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416096774 16051514
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.0617174075 2727394 7505956 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tretinoin 2.749407595
MESH:D003092 Colitis Tretinoin 3.9617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.839211117 16925845 9125849 17551590 14991402 10589399 9664655 8800419 9142499 9224671
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 4.5117654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.5119107877
MESH:D004489 Edema, Cardiac Tretinoin 4.7818230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005124 Eye Abnormalities Tretinoin 3.739664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 8.4119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 8.4121071580 20387270
MESH:D005355 Fibrosis Cyclosporine 9.5712639820 12168785
MESH:D005355 Fibrosis Tretinoin 9.5717994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.999664655 14991402
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D007333 Insulin Resistance bisphenol A 3.4116393666
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1115992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.448314463 18776723 10903974
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9012371664
MESH:D007938 Leukemia Tretinoin 2.8617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9019285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1019850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2816935935 17368321 19029980 12679006 17301526 16140955 17294898 17506722 17361223 16766008 19642359 15748426 19035177 16331271 16788101 17217047 16891316 17107899 19225113 17712046 16823087 9834237 17649720 17339181 19075265
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318522880 18407596 20032147 18665156 19638242
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8116248980 18397230
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1417034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 4.9919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.9918648771 19090486 19426721 19996281 18977376 19833225 19294768 19642983 19690152 2862719 18644402 19255062 15175105 15885732 19254457 20434301 20101389 18978307 18754104 19551842 19499222 21167192 12771043 20583210 21047994 19256749 20405173 20501860 20452335 2422723 10737359 21071580 19427195 20118626 19073162 9163691 19638242 19850985 20492335 19812893 12112319 20137499 21278145 16942905
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.5418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.5419126423 18775883 18253720 19009564 3124819 2563599 18079962 19539802 18164116 19004024 18544905 19519916 18308698 9362446 18282651 18093689 16842330 17174075 17942915 17854601 21159647 16267830
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20512841 20970405 6695378
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1917596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D009369 Neoplasms Tretinoin 2.4916946489 16594593
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 10.6011399458 16427766
MESH:D009421 Nervous System Malformations Tretinoin 10.609125849
MESH:D009436 Neural Tube Defects Tretinoin 3.189142499
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D010049 Ovarian Diseases bisphenol A 5.2711985600
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4616540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4615976015
MESH:D011230 Precancerous Conditions Cyclosporine 9.5612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.562563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.2410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.4120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.5216740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.5216205645
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D011629 Puberty, Precocious bisphenol A 5.0710548101
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.6916467112
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4618456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4617261132
MESH:D019966 Substance-Related Disorders bisphenol A 4.2716045194 16684133
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.697505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014591 Uterine Diseases bisphenol A 5.3314652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
Pathway ID Pathway Name
KEGG:05130 Pathogenic Escherichia coli infection
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24972
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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