AutismKB 2.0

Annotation Detail for BUB3


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Basic Information Top
Gene Symbol:BUB3 ( BUB3L,hBUB3 )
Gene Full Name: budding uninhibited by benzimidazoles 3 homolog (yeast)
Band: 10q26.13
Quick LinksEntrez ID:9184; OMIM: 603719; Uniprot ID:BUB3_HUMAN; ENSEMBL ID: ENSG00000154473; HGNC ID: 1151
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04110Cell cycle
Pathway IDPathway Name
APC-Cdc20 mediated degradation of Nek2A
Cell Cycle, Mitotic
DNA Replication
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cell Cycle Checkpoints
No data
No data
Pathway IDPathway Name
500396APC/C:Cdc20 mediated degradation of mitotic proteins
500328Inactivation of APC/C via direct inhibition of the APC/C complex
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of BUB3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of BUB3 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of BUB3 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of BUB3 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of BUB3 mRNAincreases expression 17879257
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of BUB3 proteinincreases expression 20097212
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BUB3 mRNAdecreases expression 20382639
D003520 Cyclophosphamide [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BUB3 mRNAaffects cotreatment|affects expression 16322899
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of BUB3 mRNAincreases expression 19031421
D004317 Doxorubicin [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BUB3 mRNAaffects cotreatment|affects expression 16322899
D005472 Fluorouracil BUB3 protein affects the susceptibility to Fluorouracilaffects response to substance 15548681
D005472 Fluorouracil Fluorouracil results in decreased expression of BUB3 proteindecreases expression 15585135
16803524
D008628 Mercury Mercury results in decreased expression of BUB3 mRNAdecreases expression 16823088
C059514 resveratrol resveratrol results in increased expression of BUB3 mRNAincreases expression 12002526
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury resveratrol 3.9616538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.4520464547 20127859
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 10.4516033868
MESH:D000230 Adenocarcinoma Doxorubicin 10.4517418594
MESH:D000230 Adenocarcinoma Fluorouracil 10.4517638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 16.523712494
MESH:D000236 Adenoma Benzo(a)pyrene 16.526695378
MESH:D000236 Adenoma Dimethylnitrosamine 16.5219555203
MESH:D000236 Adenoma resveratrol 16.5215688382
MESH:D000419 Albuminuria Doxorubicin 4.6721441931
MESH:D000544 Alzheimer Disease resveratrol 2.5916162502 16183991
MESH:D000740 Anemia Fluorouracil 3.8115504547 16511603 17963324
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.7415014928
MESH:D001169 Arthritis, Experimental resveratrol 3.5617115116
MESH:D050197 Atherosclerosis resveratrol 3.3316873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 5.0116634805
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1911289319 1440618
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8714601052
MESH:D002545 Brain Ischemia resveratrol 4.4417600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.9117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3917474063 20146248
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.3911325840 18234424 16978400 12006526 15093573 18323546 15136595 17388661 17020986
MESH:D001943 Breast Neoplasms Doxorubicin 2.3916595493 16096432 15634643 19526202 15993339 15939500 15692762 18695136 16264153 18628466 16826403 18234424 15136595 17369602 15994142 16322301 18382427 16115903 17426702 11325840 16935488 15567936 15668708 17983394
MESH:D001943 Breast Neoplasms Fluorouracil 2.3915136595 16595493 18608205 16110121 16557594 19217205 18357371
MESH:D001943 Breast Neoplasms resveratrol 2.3917651959 16393696 17534123
MESH:D002276 Carcinoid Tumor Doxorubicin 12.9416051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.9416051944
MESH:D002277 Carcinoma Dimethylnitrosamine 8.9319555203
MESH:D002277 Carcinoma Fluorouracil 8.9317121937
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 17.2716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 17.2716705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 17.277296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.273084413
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 17.2719701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 17.2718059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 17.2717971768 18930000 17088986 17045692 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular resveratrol 17.2716227395 19321006
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 12.0116152834
MESH:D018827 Carcinoma, Lewis Lung resveratrol 12.0116675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 15.787296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 15.7816201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 15.7816201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 15.7818695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 14.6820419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 14.6816033868
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 14.686189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.6818986760 17066447 16757204 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 14.6816227395
MESH:D009202 Cardiomyopathies Doxorubicin 3.6017131338 16612575 16731534 17329180 16651473 15476868 16364871 16455267 17519947 17308081 17382496 17351982 16269455 17924179 17974986 16242529 18627295 16109756 15792986 16278810 15505089 17007740 17928571 15811867 16952015
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.2916243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Mercury 6.2910334427
MESH:D002318 Cardiovascular Diseases resveratrol 3.5515458977
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.616135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.617505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6120889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.239022650 19486331
MESH:D003092 Colitis resveratrol 4.2716474422
MESH:D003110 Colonic Neoplasms Fluorouracil 3.9716510598 16340194 15001691 18772588 17725105 17169374 17287894 17018589 17016597 17172411
MESH:D003110 Colonic Neoplasms resveratrol 3.9716338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.5818802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.5818509181 17016601 18383874 17594712 17695437 14970324 16282729 18448328 16303861 16391804 20501625 15289873 17454858 17401013 18802399 15148649 16524972 17094418 18949393 17255274 16331619 18288408
MESH:D015179 Colorectal Neoplasms resveratrol 3.5816550006
MESH:D003327 Coronary Disease resveratrol 3.8216507316
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003556 Cystitis Cyclophosphamide 5.1618483878 12161096 12388444 18710439 16989017 15643279 17979934 16651033 18295254 17010015 18372110 15276878 11948286 16614059 10700343 10498854 16413132 18093676 18433785 12913760
MESH:D007644 Darier Disease Fluorouracil 4.9516733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.658156756 11298694 18759878 8970840 12868966 14531868 2524372 11906362
MESH:D017449 Dermatitis, Allergic Contact Mercury 7.6516823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 8.9915331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 8.9916873680
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2518772604
MESH:D003928 Diabetic Nephropathies resveratrol 4.0616286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.6818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.6818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 15.6816192314 6679447 1440618 9022650 7440962 11289319 18289764 6482804 18648102 9328219 18692083 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.6819739265 16393943 11287661 12392966 16177239 2444490 14986274 11421492 17906064 15968718 11834606 15619225 16227642 19420014 12958197 19164858 16109766 19923254 16081117 17522070 19085960 12594235 10915739 10774834 14550746 12540782 11743745 17562736 19370779 12705907 12153990 10663392 19416960 18071297 11529661 16781746 18713872 11461765 11739529 16485898 14725611
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 15.688172417
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.6817416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Doxorubicin 3.7518602426
MESH:D004487 Edema resveratrol 3.478985016
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 4.1517872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3318037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.9917923197
MESH:D004802 Eosinophilia Cyclophosphamide 4.3511006010
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 14.123581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.1220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 14.1216530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 14.1217016578
MESH:D004938 Esophageal Neoplasms Fluorouracil 14.1216481741 17638652 16785472 15173087 16337965
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7419069698
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005909 Glioblastoma Doxorubicin 3.4217150277
MESH:D005910 Glioma Fluorouracil 2.9116145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.6711389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.1716376943 11014644 15172196
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.1615692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 8.1615162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006331 Heart Diseases Doxorubicin 3.5616244371 18674790 17888722 16707910 18006777 16879835 16144979 16330681 16495754 16244372 12587719 14766674 17875725
MESH:D006333 Heart Failure Doxorubicin 3.4117481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0115692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.4311918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.7114986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.646705139
MESH:D006561 Herpes Simplex resveratrol 4.3316876885
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.0316135485 17606976
MESH:D006689 Hodgkin Disease Doxorubicin 8.0315147373 17606976 18501091
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006937 Hypercholesterolemia resveratrol 4.1117188708
MESH:D006949 Hyperlipidemias resveratrol 4.1416873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4117488730
MESH:D007154 Immune System Diseases Cyclophosphamide 5.5116076520
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.7817600658
MESH:D007248 Infertility, Male Cyclophosphamide 3.6916517039 7193160
MESH:D007249 Inflammation resveratrol 2.8916366677
MESH:D007251 Influenza, Human resveratrol 4.7216624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 10.5615629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 10.5616775033 15369732 15699352
MESH:D007674 Kidney Diseases Mercury 10.5617934191
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2616707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.5616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.5616705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.566582329
MESH:D007680 Kidney Neoplasms Fluorouracil 18.5616985049
MESH:D007938 Leukemia Cyclophosphamide 3.5410602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5417296974 17008537 17802794 17658394 18587576 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.1710373061
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6416087638
MESH:D007970 Leukopenia Cyclophosphamide 5.1210052129 11830472
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 2.9115086199 18210741 15798949 15479170 14659978 16042886 15733078 17036385 15366600 17198567 12918455 16169303 17534399 18672772 17640959 15138612 15842777 17432682 18237412 18364076 16270385 18239293 18637143 12925901 15339415 15763062 18567088 15081153 18371158 18095165 15744066 17881167 15723089 16544323 15571005 15864749 18629640 15942678 15504291 15492853 14568256 17465448 16627068 15298665 16009107 17196135 17724770 15067225 16570917 17719030 17203207 15099470 17201889 17666798 15383259 17348192 15161499 14709902 16603200 15577212 14726149 15591649 15793283 14643895 15369754
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.9116439617 16595196
MESH:D008107 Liver Diseases Acetaminophen 1.6512969438 11587558 19784758 16610002 16611625 12587719 19460945 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 10.0216871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 10.0217457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.687678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.6821137059 20195826
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 14.6815890375 3113478
MESH:D008113 Liver Neoplasms Fluorouracil 14.6816603448 15113037 17045692 18383874
MESH:D008113 Liver Neoplasms resveratrol 14.6819073162 20405173 19321006 19812893
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.742876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.74598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 14.746150874 15603536 1848544
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.7417085340 16842330
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 5.0118520028 20135361 17053015 6695378 20464547 18816296 20869020 20064080 18569708
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 5.0116061637 19555203 11884234
MESH:D008175 Lung Neoplasms Doxorubicin 5.016189445 17418594
MESH:D008175 Lung Neoplasms Fluorouracil 5.0115246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9515086387
MESH:D008223 Lymphoma Cyclophosphamide 8.1412854902
MESH:D008223 Lymphoma Doxorubicin 8.1416098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 10.8716675587
MESH:D016393 Lymphoma, B-Cell resveratrol 10.8717088997
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 15.2011911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 15.2017654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 15.2014749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7015621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4015688416
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.5515458769
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.558985016 11606380
MESH:D008545 Melanoma Doxorubicin 3.6416827129
MESH:D008545 Melanoma resveratrol 3.6417992120
MESH:D008546 Melanoma, Experimental Acetaminophen 11.3019513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 11.3016388313
MESH:D008654 Mesothelioma Doxorubicin 3.1017638057
MESH:D008659 Metabolic Diseases resveratrol 4.4917112576
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6115792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.8116381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.8116757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.9417415656
MESH:D009101 Multiple Myeloma resveratrol 3.5417164350 17049120 16267019 14749477 16490592 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.0217962980
MESH:D009203 Myocardial Infarction Doxorubicin 6.1719429709 15857846
MESH:D009203 Myocardial Infarction resveratrol 6.1716525036 16456233 17188708 17015251 16317513 17125593
MESH:D017202 Myocardial Ischemia resveratrol 4.0917125593 17015251
MESH:D009205 Myocarditis resveratrol 4.9117322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.983581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6811141357
MESH:D009369 Neoplasms Cyclophosphamide 8.6818854779
MESH:D009369 Neoplasms Fluorouracil 8.6816928823 18600527 18239605
MESH:D009374 Neoplasms, Experimental resveratrol 4.148985016
MESH:D009401 Nephrosis Doxorubicin 4.9116899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1016889571 15640375
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D009447 Neuroblastoma Cyclophosphamide 7.398761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 7.3915555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.6618514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.6617652729
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.048761367 12837982
MESH:D020078 Neurogenic Inflammation resveratrol 4.5217929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5116436463
MESH:D009503 Neutropenia Cyclophosphamide 4.448291058
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.6816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.6816049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.684026338 6482804
MESH:D009845 Oligospermia Cyclophosphamide 4.8616517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.3717513867
MESH:D012516 Osteosarcoma Doxorubicin 4.2015930896
MESH:D010146 Pain Acetaminophen 7.1616870215
MESH:D010146 Pain Cyclophosphamide 7.1618093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 5.7211332152
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.7215113037 16929163 16500647 19003803
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3317638057
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8621297632
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 4.3316679765
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.8817136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8815897917 16729912 15749863 16868541 18437689 16888761
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.8819082440 18626508
MESH:D011471 Prostatic Neoplasms resveratrol 1.8817636462 15767336 17804756 16731767 17718901 17675339
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3216636934
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1118722050 16160472 15538739 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 4.3617922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.7616325855
MESH:D015427 Reperfusion Injury resveratrol 3.3216317513 16314181 17058453 17520802 15827377
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012509 Sarcoma Doxorubicin 4.0915675481 16767912 17203757 17710206 18313854 15625365
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3716326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9417846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.9416636934
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8519755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 9.8515692506
MESH:D012878 Skin Neoplasms resveratrol 9.858985016 15837718
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7017203757 16767912 15625365
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.6716517039
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.4412587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.5020155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 3.5016033868
MESH:D013274 Stomach Neoplasms Fluorouracil 3.5016424979 18567086 17172411 18396642 17498489 17522103 19015929 19084572 16951190 15786421
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.5816321402
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.2112837982
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.547505956 1399818 3712494 6587162 6582329
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.5417909728 16010429
MESH:D014062 Tongue Neoplasms Fluorouracil 10.3316280240
MESH:D014062 Tongue Neoplasms resveratrol 10.3316227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 20.4216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 20.4216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 20.428074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 20.4217053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 20.4214692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 20.4217653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.9516803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.9517473185
MESH:D014594 Uterine Neoplasms resveratrol 4.2617044934
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 10.8117638931 16364871 17678736 17334414
MESH:D018487 Ventricular Dysfunction, Left resveratrol 10.8117488730
Pathway ID Pathway Name
REACT:8017 APC-Cdc20 mediated degradation of Nek2A
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
REACT:383 DNA Replication
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25467
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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