AutismKB 2.0

Annotation Detail for SLC16A7


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Basic Information Top
Gene Symbol:SLC16A7 ( MCT2 )
Gene Full Name: solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
Band: 12q14.1
Quick LinksEntrez ID:9194; OMIM: 603654; Uniprot ID:MOT2_HUMAN; ENSEMBL ID: ENSG00000118596; HGNC ID: 10928
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SLC16A7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SLC16A7 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SLC16A7 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC16A7 mRNAdecreases expression 20018196
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC16A7 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of SLC16A7 mRNAincreases expression 19619570
D005419 Flavonoids Flavonoids results in decreased expression of SLC16A7 mRNAdecreases expression 18035473
C008493 methylselenic acid methylselenic acid results in increased expression of SLC16A7 mRNAincreases expression 18548127
D009151 Mustard Gas Mustard Gas affects the expression of SLC16A7 mRNAaffects expression 15651846
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SLC16A7 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of SLC16A7 mRNAincreases expression 19270015
19482888
D010656 Phenylephrine Phenylephrine results in decreased expression of SLC16A7 mRNAdecreases expression 18158353
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC16A7 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of SLC16A7 mRNAincreases expression 20059764
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of SLC16A7 mRNA]increases expression|increases reaction 20059764
C004648 testosterone enanthate testosterone enanthate affects the expression of SLC16A7 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SLC16A7 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SLC16A7 mRNAincreases expression 20106945
19619570
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.696195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.6915322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Estradiol 2.1111473722
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.0017620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.0016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.0016835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1917460149
MESH:D001249 Asthma Mustard Gas 2.7310378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001919 Bradycardia Phenylephrine 4.6615306635
MESH:D001943 Breast Neoplasms Estradiol 1.9314630087 17018787 17261762 16675129 17289903 19861407 12948864 18497071
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.653084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6516924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.6517173139 20935162 6705139 20007298 1701930
MESH:D006332 Cardiomegaly Phenylephrine 7.0216170337 15728586 17287366 11754973 11179087 17124262
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.0218850075 16120746 18670907
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.8320889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis pirinixic acid 2.8819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 12621046 15668235 8697196 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.2421346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2418713872 17562736 12153990 14986274 12705907 16177239 17906064 15968718 19923254 19164858 10915739 16081117 11529661 11461765 10663392 18071297 2444490 19085960 12540782 11834606 11739529 10774834 11287661 12594235 11743745 16781746 14550746 11421492 15619225 16227642 14725611 17522070 19416960 16393943 19370779 16109766 16485898 19420014 12958197 12392966 19739265
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004487 Edema Mustard Gas 11.9111428647 11402378 11428631 9260866
MESH:D004487 Edema pirinixic acid 11.9112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.9111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.0318566989 11473722 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.003922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver pirinixic acid 2.8519236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Phenobarbital 15.0116109766
MESH:D006529 Hepatomegaly pirinixic acid 15.0119772884 18467677 16221962 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.0115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8817440010
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1816959395 15340226 16354765 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Phenylephrine 5.408949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4018670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.6318502941 12791704
MESH:D007249 Inflammation Flavonoids 8.6017296493
MESH:D007249 Inflammation Mustard Gas 8.6017524151 9357497 8975870 11428647 11428620 16001271 9260866 11428631 11402378
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.3716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.3716306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.0315629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.0315618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.5916705839
MESH:D007680 Kidney Neoplasms Estradiol 7.5915610895
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9421047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4212878042
MESH:D008107 Liver Diseases Acetaminophen 3.9912969438 11587558 19460945 12587719 19014921 16611625 19784758 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.9919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 7.5119812893 15975961 8742319 21047994 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 7.5115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5116984957
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 5.9518308698 1399818 17172636 2563599 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008171 Lung Diseases Mustard Gas 3.5018702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.433148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4319555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.4616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.4616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9718551238
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Estradiol 9.7811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009503 Neutropenia Mustard Gas 4.0616761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.5012819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2419401270
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5216965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.692563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.4316740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.4316205645
MESH:D011537 Pruritus Mustard Gas 4.2118058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9517620002 17266442 17720292 17894541 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures Phenobarbital 6.1111442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012852 Sinusitis Phenylephrine 4.827327846
MESH:D012871 Skin Diseases Mustard Gas 2.7312880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.111399818
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
REACT:20633 Bile salt and organic anion SLC transporters
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35819
    • No data
    Releated disease ID Related disease Name
    PA443433Arthritis, Juvenile Rheumatoid
    Releated drug ID Related drug Name
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00119 - Pyruvic acid Dietary supplement;Micronutrient
    No data
    Drugbank ID Action Drug Name Description
    DB00119 inhibitor Pyruvic acid Dietary supplement;Micronutrient
    DB01032 inhibitor Probenecid Uricosuric Agents;Adjuvants, Pharmaceutic
    DB01440 inhibitor Gamma Hydroxybutyric Acid Adjuvants, Anesthesia;Anesthetics, Intravenous
    DB01762 inhibitor Acetoacetic Acid
    DB03066 inhibitor D-Lactic Acid
    DB04074 inhibitor Alpha-ketoisovalerate
    DB04216 inhibitor Quercetin Antioxidants
    DB04319 inhibitor 6-Deoxyglucose
    DB04398 inhibitor Lactic Acid
    DB04552 inhibitor Niflumic Acid Cyclooxygenase Inhibitors
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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