AutismKB 2.0

Annotation Detail for ARRDC4


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Basic Information Top
Gene Symbol:ARRDC4 ( FLJ36045 )
Gene Full Name: arrestin domain containing 4
Band: 15q26.2
Quick LinksEntrez ID:91947; OMIM: NA; Uniprot ID:ARRD4_HUMAN; ENSEMBL ID: ENSG00000140450; HGNC ID: 28087
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ARRDC4 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ARRDC4 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ARRDC4 mRNAincreases expression 20064835
20106945
D016572 Cyclosporine Cyclosporine results in increased expression of ARRDC4 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of ARRDC4 mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of ARRDC4 mRNAincreases expression 20106945
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARRDC4 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARRDC4 mRNAaffects binding|decreases expression|increases activity 19710929
C034028 vanadyl sulfate vanadyl sulfate results in decreased expression of ARRDC4 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.4511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.786695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8216434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3819183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9120146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9111237771
MESH:D001943 Breast Neoplasms Estradiol 1.9112948864 18497071 17289903 16675129 17261762 17018787 14630087 19861407
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7112907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7116924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8920419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.8911237771
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.1118566989
MESH:D002779 Cholestasis Cyclosporine 8.3519486331
MESH:D002779 Cholestasis pirinixic acid 8.3519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003921 Diabetes Mellitus, Experimental vanadyl sulfate 4.5716684804
MESH:D003928 Diabetic Nephropathies Estradiol 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6410774834 11421492 19085960 17522070 16485898 19416960 15619225 16227642 16081117 11834606 11743745 11461765 19370779 18071297 11739529 14986274 17562736 16781746 16109766 14725611 16177239 12958197 19164858 19739265 2444490 11287661 19923254 10663392 19420014 14550746 12392966 12705907 18713872 12153990 15968718 17906064 16393943 10915739 12594235 12540782 11529661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2115138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.1311473722 18566989 19148513
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Cyclosporine 8.3819224547
MESH:D005234 Fatty Liver pirinixic acid 8.3820131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.4512168785 12639820
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7720471113
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly pirinixic acid 3.3018467677 19176532 16221962 19772884
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Cyclosporine 2.1710903974
MESH:D007333 Insulin Resistance Estradiol 7.6916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.6916306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.7212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.728314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.7215618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.9515610895
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3615474484
MESH:D008107 Liver Diseases Acetaminophen 1.6711587558 16611625 12587719 16610002 19784758 12969438 19014921 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.869163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.8621137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.8615890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.888603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4720869020 17053015 20064080 20464547 18816296 20135361 18569708 6695378 18520028
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7011408345 16891317 17203775 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.8619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3716381670
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.8716411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1711141357
MESH:D009369 Neoplasms pirinixic acid 5.1717405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 3.9316427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2819401270
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.4412371664
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5117292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.5116289102 18247401 15754350 12479363 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.5116740699
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4619755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2517053015
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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