AutismKB 2.0

Annotation Detail for DCLK1


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Basic Information Top
Gene Symbol:DCLK1 ( CL1,CLICK1,DCAMKL1,DCDC3A,DCLK,KIAA0369 )
Gene Full Name: doublecortin-like kinase 1
Band: 13q13.3
Quick LinksEntrez ID:9201; OMIM: 604742; Uniprot ID:DCLK1_HUMAN; ENSEMBL ID: ENSG00000133083; HGNC ID: 2700
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DCLK1 mRNAdecreases expression 19933214
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of DCLK1 mRNAaffects expression 18343893
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DCLK1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DCLK1 mRNAaffects expression 16483693
D001205 Ascorbic Acid Ascorbic Acid results in increased expression of DCLK1 mRNAincreases expression 15305145
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DCLK1 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DCLK1 mRNAdecreases expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of DCLK1 mRNAincreases expression 17484886
D003024 Clozapine Clozapine results in increased expression of DCLK1 mRNAincreases expression 18797397
D003024 Clozapine Clozapine results in increased expression of DCLK1 mRNAincreases expression 15860345
D016572 Cyclosporine Cyclosporine results in increased expression of DCLK1 mRNAincreases expression 20106945
C014347 decitabine decitabine affects the expression of DCLK1 mRNAaffects expression 17145863
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DCLK1 mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DCLK1 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of DCLK1 mRNAincreases expression 20106945
19619570
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLK1 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of DCLK1 mRNAdecreases expression 18035473
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of DCLK1 mRNA]affects reaction|decreases expression 15016801
D006220 Haloperidol Haloperidol results in increased expression of DCLK1 mRNAincreases expression 18797397
D006220 Haloperidol Haloperidol results in increased expression of DCLK1 mRNAincreases expression 15860345
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of DCLK1 mRNAdecreases expression 20713471
C076029 olanzapine olanzapine results in increased expression of DCLK1 mRNAincreases expression 18797397
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DCLK1 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DCLK1 mRNAincreases expression 19619570
20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of DCLK1 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DCLK1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of DCLK1 mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DCLK1 mRNAincreases expression 15328365
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7615322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.4718287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.9820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.9811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.9814692618
MESH:D000230 Adenocarcinoma Fluorouracil 9.9817638652
MESH:D000236 Adenoma Benzo(a)pyrene 15.606695378
MESH:D000236 Adenoma beta-Naphthoflavone 15.6019389873
MESH:D000236 Adenoma Diethylnitrosamine 15.6010737359 6695378
MESH:D000236 Adenoma Methylcholanthrene 15.606695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.7717162532 19061943 16434500 19052882 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7716835633
MESH:D000380 Agranulocytosis Clozapine 4.9714617031 16160616 12649775
MESH:D000740 Anemia Fluorouracil 8.4216511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.4211748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.4011922910
MESH:D001321 Autistic Disorder Haloperidol 2.8418080171 19368416
MESH:D001321 Autistic Disorder olanzapine 2.8418685284 17069543
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7115746008
MESH:D001943 Breast Neoplasms Ascorbic Acid 4.6716443354
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.6717474063 20146248
MESH:D001943 Breast Neoplasms decitabine 4.6718320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 4.6717474063
MESH:D001943 Breast Neoplasms Estradiol 4.6717289903 14630087 12948864 18497071 16675129 17261762 19861407 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 4.6718357371 16595493 16110121 15136595 16557594 19217205 18608205
MESH:D001943 Breast Neoplasms Methylcholanthrene 4.6717474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3816111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.693786805 15673190 16011737 16227642 16097048 16050911 16124888 15700767 18705752 15721981 10355542 16192424
MESH:D002276 Carcinoid Tumor Fluorouracil 4.5916051944
MESH:D002277 Carcinoma Fluorouracil 13.5717121937
MESH:D002277 Carcinoma Methylcholanthrene 13.5710545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 13.5716835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.7312907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7318056438 21159647 16878318 17978847 10737359 17138121 10672840 19822196 18665156 20727157 18788625 19539802 20514400 16328049 16681979 18506893 18691550 17173139 20432363 19052882 18971187 17761372 19919837 16502159 19418558 11831363 19519916 19171122 17162532 20007298 20524982 17055752 20101231 3084413 20935162 18393292 17428255 16288022 16830150 16779866 18494052 18210153 16540662 16935385 20512989 20214788 18978308 19208518 16807293 16569478 18785209 19701751 19107877 19383236 19335982 19394651 3581430 20084675 16698587
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.7316924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.7318930000 17045692 17088986 16332177 17971768 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.9818695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.4220419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.4219215824
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.4217066447 16757204 16280240 18986760
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3216120746 18670907 18850075
MESH:D002375 Catalepsy Haloperidol 4.821977408 15215559
MESH:D002389 Catatonia olanzapine 6.1716772815 18071103
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.5412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.547505956 2727394 21159647 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.5418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 15.5416192471
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.0719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0716835633
MESH:D002779 Cholestasis Cyclosporine 7.5619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5616105132 11677210 16919318 15861022 17681005 17110522 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0716354765 12621046 8697196 15668235 15340226
MESH:D003072 Cognition Disorders Clozapine 4.8817123785
MESH:D003110 Colonic Neoplasms decitabine 3.8117616700
MESH:D003110 Colonic Neoplasms Fluorouracil 3.8116340194 18772588 15001691 17018589 16510598 17172411 17725105 17287894 17016597 17169374
MESH:D015179 Colorectal Neoplasms decitabine 2.6118981723
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6120501625 16282729 15148649 16391804 16303861 15289873 18383874 17016601 17454858 17594712 17255274 17094418 18509181 18448328 17695437 18949393 16331619 18288408 14970324 16524972 17401013 18802399
MESH:D003139 Common Cold Ascorbic Acid 5.3917323712
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2515322242 10048152 20055451
MESH:D007644 Darier Disease Fluorouracil 4.7116733453
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.7620210726
MESH:D003704 Dementia Haloperidol 4.5011575062
MESH:D002658 Developmental Disabilities olanzapine 4.6317069543
MESH:D003924 Diabetes Mellitus, Type 2 Ascorbic Acid 10.1216506275
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 10.1216402076
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 10.1220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 10.1217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3319279558
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.4715331141
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.0417522070 10092053 16177239 15027814 7440962 19336974 4309450 6623471 19085960 7120509 16227642 3786805 2869522 10915739 15968718 7179309 9327722 3732212 21278145 15998439 6884620 11566570
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.0419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6911462148
MESH:D050171 Dyslipidemias Clozapine 4.1216402076
MESH:C538011 Eales disease Ascorbic Acid 5.399068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1012538720
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.0319294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.9211473722 18566989 19148513
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9410568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0416302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4116337965 16481741 17638652 15173087 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9511564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.0816239168 12795759 15959796 17595544 12631006 61145 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 18.0819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 18.0820387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.0815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3711858732
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.8510962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 14.2118705752
MESH:D005355 Fibrosis Cyclosporine 14.2112168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2120067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D005910 Glioma Fluorouracil 2.8316145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5110696789
MESH:D006258 Head and Neck Neoplasms decitabine 7.7019215824
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.7015162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 15.6811294989
MESH:D006330 Heart Defects, Congenital Ascorbic Acid 15.6816080930
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 15.6820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 15.6811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2511000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5119900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Ascorbic Acid 3.4416490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 4.9515709030
MESH:D019584 Hot Flashes Estradiol 3.6717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.968697196 16959395 15340226 16354765 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4516899240
MESH:D006948 Hyperkinesis Clozapine 4.8216046005
MESH:D006963 Hyperphagia olanzapine 6.1417933447
MESH:D006973 Hypertension Cyclosporine 4.8310903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male decitabine 6.5217581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.5217937319
MESH:D007249 Inflammation Diethylnitrosamine 8.0418785209
MESH:D007249 Inflammation Flavonoids 8.0417296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.0412878042 12200463
MESH:D007333 Insulin Resistance Estradiol 2.9116627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Cyclosporine 5.778314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.7715618244
MESH:D007680 Kidney Neoplasms Cyclosporine 11.9812371664
MESH:D007680 Kidney Neoplasms Estradiol 11.9815610895
MESH:D007680 Kidney Neoplasms Fluorouracil 11.9816985049
MESH:D007938 Leukemia decitabine 3.0318980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.9217236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3619010910 18206229 18460780 19387464 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.3818055864
MESH:D008064 Lipidoses Clozapine 3.9017567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4517174718 16943688 17334410 11903743 11408273 16221502 21278145 16239168 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4518522880 19638242 18665156 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3714716496 18317297 12649538 17944888 14512876 18205269 18472094 18279442 17900296 16027843 17698563 14724832 17714472 10355542 16097048 15996030 12666154 15650968 17823541 12958196 15370692 15893842 16638106 12741479 18277467 20821823 16136751 15362042 17708605 11481614 14716833 18339082 18054572 16033810 12632514 12586293 12389079 15123356 17922224 15052691 18251166 18481824 12609069 18166357 16015684 17565644 15931870 18429990 15925388 18705752 14748882 15057751 17869086 16116963 16011737 17721639 18263696 17631135 15959796 12667390 18395095 17525996 17557913 18187930 15818738 18412020 17761835 18418968 18376398 16192424 14620537 18210741 12445418 12445421 17481882 15730626 18472332 17766677 18006644 17640975 18420326 18395914 12898905 15876570 17976157 12632512 15338365 16248980 15673190 18156304 17805973 12546737 13678700
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0015830285 15720792 16964402 16246199 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0017034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0815123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.6114706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.4115890375 9163691 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.4120195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.4119389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.4119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.4120118626 21278145 2862719 16942905 19090486 18754104 20501860 19073162 19551842 19812893 2422723 18648771 18978307 19426721 19642983 19294768 21071580 19638242 15885732 19690152 20405173 19499222 20583210 20452335 19256749 18977376 19255062 20101389 19833225 19254457 19996281 20137499 9163691 12112319 21167192 12771043 20434301 15175105 19427195 18644402 21047994 19850985 20492335 10737359
MESH:D008113 Liver Neoplasms Fluorouracil 21.4117045692 15113037 18383874 16603448
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.4116984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 27.458603461
MESH:D008114 Liver Neoplasms, Experimental Ascorbic Acid 27.4518544905
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 27.4518164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 27.4512014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 27.4518282651 18775883 18093689 18079962 18253720 18544905 19126423 9362446 18164116 19539802 18308698 17174075 19519916 19009564 16842330 16267830 17854601 19004024 3124819 2563599 17942915 21159647
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 27.451399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 27.4512151625
MESH:D008133 Long QT Syndrome olanzapine 4.6620210726
MESH:D008171 Lung Diseases Ascorbic Acid 3.8916863852
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.5514755239
MESH:D008175 Lung Neoplasms Ascorbic Acid 10.5516401635
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.5520064080 20464547 20135361 18569708 18520028 18816296 20869020 6695378 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.556695378 21163286 20512841 20970405
MESH:D008175 Lung Neoplasms Fluorouracil 10.5515246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 10.557750092 16271038 20970405 21163286 9230183 10545420 16337739 20512841 17909032 15390079 6695378 1399818 11893704
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.5519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7115086387
MESH:D008223 Lymphoma decitabine 3.3519470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5011807958 16891317 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.4019453300
MESH:D008545 Melanoma decitabine 2.2316505122 17785578
MESH:D001523 Mental Disorders Clozapine 12.9516856516
MESH:D001523 Mental Disorders Haloperidol 12.9516856516
MESH:D001523 Mental Disorders olanzapine 12.9516856516
MESH:D008659 Metabolic Diseases olanzapine 5.3119142110
MESH:D024821 Metabolic Syndrome X Clozapine 4.3419142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.3016381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.3016757204 18986760
MESH:D009101 Multiple Myeloma decitabine 3.2818172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.3319157545 18608210 19010910 16882708
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2116810080
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.533581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0711141357
MESH:D009369 Neoplasms decitabine 8.0719116145 19470736 17925555
MESH:D009369 Neoplasms Fluorouracil 8.0716928823 18600527 18239605
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2118481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 9.1816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1814600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.2720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0420387270
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3816436463
MESH:D009765 Obesity Ascorbic Acid 7.7217217161
MESH:D009765 Obesity Clozapine 7.7219142110 18515891
MESH:D009765 Obesity olanzapine 7.7218515891
MESH:D010051 Ovarian Neoplasms decitabine 4.8219259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 4.8219401270
MESH:D010190 Pancreatic Neoplasms decitabine 8.4919294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.4916540662
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.4919003803 16929163 16500647 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.6912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.692563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1111118676 11399792 11896295 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.6417616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8020887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5617292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.5616740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5618626508 19082440
MESH:D011537 Pruritus Ethinyl Estradiol 3.2315861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2016882103
MESH:D011595 Psychomotor Agitation Haloperidol 11.5311575062
MESH:D011595 Psychomotor Agitation olanzapine 11.5318685284
MESH:D011618 Psychotic Disorders Clozapine 8.9415331141
MESH:D011618 Psychotic Disorders Haloperidol 8.9411575062
MESH:D011657 Pulmonary Eosinophilia Ascorbic Acid 5.2514606601
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9318722050 16160472 18286688 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7518990726
MESH:D012174 Retinitis Pigmentosa Ascorbic Acid 3.2916849425
MESH:D012208 Rhabdomyosarcoma decitabine 4.3219155313
MESH:D012559 Schizophrenia Clozapine 5.8220452607 17123785 18855531 11151749 11763009 20521326 17667964 16141801 20580759 20168265 17726453 20521320 20107430 18806925 19369910
MESH:D012559 Schizophrenia Haloperidol 5.821830565 20107430 19369910 18513383
MESH:D012559 Schizophrenia olanzapine 5.8220521326 20107430 17726453
MESH:D012871 Skin Diseases Ascorbic Acid 3.1918709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.3319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.6620155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.6619037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6618456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.6619084572 17522103 15786421 16424979 16951190 17498489 17172411 18567086 19015929 18396642
MESH:D013276 Stomach Ulcer Ascorbic Acid 3.8118726076
MESH:D020521 Stroke Ascorbic Acid 4.2216517955 16403987
MESH:D017180 Tachycardia, Ventricular Haloperidol 10.6720210726
MESH:D017180 Tachycardia, Ventricular olanzapine 10.6720210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8212697716
MESH:D013964 Thyroid Neoplasms decitabine 7.0517967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.057505956
MESH:D013978 Tibial Fractures Estradiol 4.6019048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9116280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0217053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.0217616700 19087683
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8016803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014604 Uveal Neoplasms decitabine 4.8317785578
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4615869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1715886252
MESH:D015430 Weight Gain Clozapine 10.0916141801 17502770 20107430 16402076 20521320 20564506
MESH:D015430 Weight Gain olanzapine 10.0917933447 20107430 19434072
MESH:D015431 Weight Loss Clozapine 4.9917933447
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA162383325
    • No data
    Releated disease ID Related disease Name
    PA443635Cardiovascular Diseases
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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