AutismKB 2.0

Annotation Detail for BMP15


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Basic Information Top
Gene Symbol:BMP15 ( GDF9B,ODG2,POF4 )
Gene Full Name: bone morphogenetic protein 15
Band: Xp11.22
Quick LinksEntrez ID:9210; OMIM: 300247; Uniprot ID:BMP15_HUMAN; ENSEMBL ID: ENSG00000130385; HGNC ID: 1068
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
P00052TGF-beta signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2102Polycystic ovary syndrome
2121Ovarian failure
Desease Name
premature ovarian failure
REPRODUCTION
amenorrhea premature ovarian failure
ovarian hyperstimulation syndrome
No data
Desease Name
Premature ovarian failure 4
Ovarian dysgenesis 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of BMP15 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of BMP15 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A affects the reaction [CYP19A1 affects the expression of BMP15 mRNA]affects expression|affects reaction 11985600
D004958 Estradiol Estradiol affects the reaction [CYP19A1 affects the expression of BMP15 mRNA]affects expression|affects reaction 11985600
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of BMP15 mRNAdecreases expression 16954407
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of BMP15 mRNAaffects binding|decreases expression|increases activity 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Estradiol 4.4311473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4314692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001862 Bone Resorption bisphenol A 4.1911985600
MESH:D001943 Breast Neoplasms bisphenol A 2.1917123778
MESH:D001943 Breast Neoplasms Estradiol 2.1912948864 17289903 17018787 19861407 14630087 17261762 16675129 18497071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.077296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0716924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.4517123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.367505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.3618566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.7419486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 14.7417110522 15861022 11677210 16919318 17333356 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 14.7419176532
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2118759878 2524372 11906362 14531868 11298694 12868966 8970840 8156756
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D003928 Diabetic Nephropathies Estradiol 3.7019279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.0318692083 16192314 18648102 7440962 11289319 1440618 9653073 18289764 9022650 6482804 8291058 9328219 6679447
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D016889 Endometrial Neoplasms Estradiol 3.1719148513 18566989 11473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6515345470
MESH:D005234 Fatty Liver pirinixic acid 8.6520131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly pirinixic acid 3.4118467677 19772884 19176532 16221962
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007333 Insulin Resistance bisphenol A 13.4616393666
MESH:D007333 Insulin Resistance Estradiol 13.4616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 13.4616306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007674 Kidney Diseases Estradiol 2.7415618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.266582329
MESH:D007680 Kidney Neoplasms Estradiol 8.2615610895
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3714659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9120007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.716587162 3712494 1399818 598648
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7411408345 17203775 11807958 16891317
MESH:D020149 Manganese Poisoning Estradiol 5.0019453300
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.0616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 9.0616411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations bisphenol A 11.0416427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 11.0416427766 11399458
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010049 Ovarian Diseases bisphenol A 5.4511985600
OMIM:300510 OVARIAN DYSGENESIS 2 marker/mechanism
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.4110548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.6620887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.6620887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2016740699
MESH:D011471 Prostatic Neoplasms Estradiol 3.2016740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.7715861022 16919318
MESH:D011629 Puberty, Precocious bisphenol A 5.2510548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.4516045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.121399818 3712494 6587162 7505956 6582329
MESH:D013978 Tibial Fractures Estradiol 5.2119048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
MESH:D014591 Uterine Diseases bisphenol A 5.5314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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