AutismKB 2.0

Annotation Detail for TIAF1


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Basic Information Top
Gene Symbol:TIAF1 ( MAJN,SPR210 )
Gene Full Name: TGFB1-induced anti-apoptotic factor 1
Band: 17q11.2
Quick LinksEntrez ID:9220; OMIM: 609517; Uniprot ID:TIAF1_HUMAN; ENSEMBL ID: ENSG00000221995; HGNC ID: 11803
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D003474 Curcumin Curcumin results in increased expression of TIAF1 mRNAincreases expression 18421014
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of TIAF1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of TIAF1 mRNAincreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of TIAF1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of TIAF1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D019973 Alcohol-Related Disorders Curcumin 5.9517887948
MESH:D000544 Alzheimer Disease Curcumin 2.6915590663
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.8116807698
MESH:D050197 Atherosclerosis Curcumin 3.5518704882
MESH:D001327 Autoimmune Diseases Curcumin 5.1419761891
MESH:D002545 Brain Ischemia Curcumin 5.0716770732
MESH:D001932 Brain Neoplasms Curcumin 4.3817596214
MESH:D001943 Breast Neoplasms Curcumin 2.7018462866 18593918 16243823 19250217
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.5816050911
MESH:D002277 Carcinoma Curcumin 4.2018593918
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0918414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.8518462866
MESH:D003092 Colitis Curcumin 11.9416782535 18200517 16804969
MESH:D003092 Colitis Selenium 11.9417936198
MESH:D003103 Coloboma Curcumin 5.0318809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5619359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.5518497527
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7818403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.4318204486
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2615131321
MESH:D004381 Duodenal Ulcer Curcumin 4.6317351913
MESH:C538011 Eales disease Vitamin E 5.579068938
MESH:D005234 Fatty Liver Curcumin 4.1819297423
MESH:D005355 Fibrosis Curcumin 4.6318705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.3518462866
MESH:D005909 Glioblastoma Curcumin 3.7417596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.9418829502 18462866
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1816080930
MESH:D006333 Heart Failure Selenium 3.3217162251
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.6917701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8216863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.8414716179
MESH:D006937 Hypercholesterolemia Curcumin 4.5418704882
MESH:D007249 Inflammation Curcumin 3.0818403477 16956363 17151092
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3418200517 18596194
MESH:D007251 Influenza, Human Selenium 14.0716624496
MESH:D007251 Influenza, Human Vitamin E 14.0716624496
MESH:D007414 Intestinal Neoplasms Curcumin 4.6710783313
MESH:D007674 Kidney Diseases Vitamin E 3.0312488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.3716518626
MESH:D007889 Leiomyoma Curcumin 5.1018555241
MESH:D007938 Leukemia Curcumin 3.4218462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.6916106398
MESH:D015458 Leukemia, T-Cell Curcumin 5.3516106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.8218006644 17355460 18705752
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.8216169303
MESH:D008107 Liver Diseases Curcumin 2.6916956363
MESH:D008171 Lung Diseases Vitamin E 3.4516863852
MESH:D008175 Lung Neoplasms Curcumin 2.7818462866 19359593 16243823
MESH:D008175 Lung Neoplasms Vitamin E 2.7811062179
MESH:D008223 Lymphoma Curcumin 3.8918462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.3516173963
MESH:D008325 Mammary Neoplasms, Experimental Selenium 3.0215318939
MESH:D008545 Melanoma Curcumin 2.4618462866 17885582
MESH:D008569 Memory Disorders Curcumin 4.7417263510
MESH:D008654 Mesothelioma Selenium 2.9315107826
MESH:D009101 Multiple Myeloma Curcumin 3.8219372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.6617962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.9518495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 5.4012497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.5018462866
MESH:D009765 Obesity Curcumin 2.8219297423
MESH:D010024 Osteoporosis Curcumin 3.7118719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.9218462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0519401701 17440100 19196508
MESH:D010954 Plasmacytoma Selenium 5.7615087411
MESH:D011471 Prostatic Neoplasms Curcumin 3.3615129424 10851300 11398177 18226269 18156803 12497104 18769126
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3615084515
MESH:D011656 Pulmonary Emphysema Curcumin 4.9819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.5510666014 18379247
MESH:D012509 Sarcoma Curcumin 4.5618462866
MESH:D018805 Sepsis Curcumin 4.4618389075
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D013276 Stomach Ulcer Curcumin 3.9719188055 16631530
MESH:D020521 Stroke Vitamin E 3.8816517955
MESH:D001749 Urinary Bladder Neoplasms Curcumin 3.0218593936
MESH:D014565 Urogenital Neoplasms Curcumin 6.0118462866
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36512
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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