AutismKB 2.0

Annotation Detail for NOLC1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NOLC1 ( KIAA0035,NOPP130,NOPP140,NS5ATP13,P130 )
Gene Full Name: nucleolar and coiled-body phosphoprotein 1
Band: 10q24.32
Quick LinksEntrez ID:9221; OMIM: 602394; Uniprot ID:NOLC1_HUMAN; ENSEMBL ID: ENSG00000166197; HGNC ID: 15608
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063002 2,3-dimethoxy-1,4-naphthoquinone 2,3-dimethoxy-1,4-naphthoquinone results in increased expression of NOLC1 mRNAincreases expression 19031421
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of NOLC1 mRNAincreases expression 20713471
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NOLC1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NOLC1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of NOLC1 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of NOLC1 mRNAaffects expression 21346803
C075773 4-phenylbutyric acid 4-phenylbutyric acid results in decreased expression of NOLC1 mRNAdecreases expression 14583596
D000082 Acetaminophen Acetaminophen affects the expression of NOLC1 mRNAaffects expression 17562736
D000255 Adenosine Triphosphate Adenosine Triphosphate affects the reaction [Doxorubicin binds to NOLC1 protein]affects binding|affects reaction 17129415
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NOLC1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of NOLC1 mRNAdecreases expression 20458559
D002995 Clofibric Acid Clofibric Acid affects the expression of NOLC1 mRNAaffects expression 17602206
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NOLC1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of NOLC1 mRNAincreases expression 20106945
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of NOLC1 mRNAincreases expression 16493179
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of NOLC1 mRNAaffects cotreatment|affects expression 17602206
C012125 diisononyl phthalate diisononyl phthalate results in increased expression of NOLC1 mRNAincreases expression 16493179
C013966 dioctyl adipate dioctyl adipate results in decreased expression of NOLC1 mRNAdecreases expression 16493179
D004317 Doxorubicin Adenosine Triphosphate affects the reaction [Doxorubicin binds to NOLC1 protein]affects binding|affects reaction 17129415
D004317 Doxorubicin Doxorubicin binds to NOLC1 proteinaffects binding 17129415
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of NOLC1 mRNAdecreases expression 17557909
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of NOLC1 mRNAincreases expression 17351261
D005031 Ethylenethiourea Ethylenethiourea results in increased expression of NOLC1 mRNAincreases expression 18801409
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of NOLC1 mRNAincreases expression 17616710
C494474 perchlorate perchlorate results in increased expression of NOLC1 mRNAincreases expression 18801409
C006253 pirinixic acid pirinixic acid results in increased expression of NOLC1 mRNAincreases expression 18301758
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of NOLC1 mRNAaffects cotreatment|decreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of NOLC1 mRNAincreases expression 20159946
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of NOLC1 proteindecreases expression 16548065
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of NOLC1 mRNAincreases expression 19031421
D014212 Tretinoin Tretinoin results in decreased expression of NOLC1 mRNAdecreases expression 16054129
C025643 vinclozolin vinclozolin affects the expression of NOLC1 mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of NOLC1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of NOLC1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 7.617525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6111752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6817505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.6911798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 9.6917418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.6914692618
MESH:D000230 Adenocarcinoma Ethylenethiourea 9.697955072
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.163712494
MESH:D000236 Adenoma Diethylnitrosamine 6.166695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.7516434500 19052882 17162532 17620307 19061943 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.7516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.7516835633
MESH:D000419 Albuminuria Doxorubicin 4.2921441931
MESH:D000505 Alopecia Tretinoin 3.4115955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7211748828
MESH:D000799 Angioedema Acetaminophen 3.5810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6715885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.6716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2016292516
MESH:D001249 Asthma Tretinoin 2.2716456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001471 Barrett Esophagus Tretinoin 4.1516935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.751440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.0116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.0119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.0112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.0116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6015746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4314601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.5817150277
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 2.2611921183
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2617474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.2617369602 15567936 15692762 16322301 15634643 15939500 11325840 19526202 16935488 18695136 16115903 18628466 18234424 15136595 18382427 17426702 16595493 16264153 15993339 16096432 16826403 15668708 17983394 15994142
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.2616443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3316813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0911589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.6716050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.5416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8916168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.1316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.1316705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.133581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.133084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.1311135700 14691202 16217749 15553829 15073043
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.1318393292 19418558 16288022 19519916 17173139 19335982 16935385 20007298 20514400 20084675 20214788 20512989 17055752 18056438 20935162 18785209 19208518 19107877 19171122 16878318 17761372 10737359 19539802 16328049 17978847 16502159 18210153 18691550 17138121 18788625 16569478 16830150 19919837 16540662 17428255 11831363 18506893 16698587 19052882 19394651 19701751 3581430 10672840 19383236 3084413 16807293 19822196 20727157 20101231 18971187 17162532 20432363 20524982 18665156 18494052 21159647 16779866 16681979 18978308
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.1318059187 16023760 17876044 16234567
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.131917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6119014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.147296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.1416201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8912490120
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.206189445
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.2018922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.2016051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2218850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3615476868 17382496 17924179 17351982 16455267 16109756 17007740 17131338 16242529 17519947 16278810 17329180 16612575 16269455 17974986 16651473 16952015 15792986 17928571 17308081 15811867 16364871 18627295 16731534 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8617334414 16243910
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 16.4814694615
MESH:D002386 Cataract Acetaminophen 16.4810977129
MESH:D002386 Cataract Adenosine Triphosphate 16.4815003327
MESH:D002386 Cataract Tretinoin 16.4817460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.536135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.537505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.5312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.5317174075 7505956 2727394 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.6319486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.6319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.6311677210 17110522 16919318 15861022 16105132 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 17.6319176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4015668235 8697196 12621046 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.409407595
MESH:D003092 Colitis Selenium 8.6417936198
MESH:D003092 Colitis Tretinoin 8.6417035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5320501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.5318259882 18802399
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.4615095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.4614669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9312609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.1410525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.149142499 14991402 16925845 9125849 9224671 8800419 10589399 9664655 9211117 17551590
MESH:D019465 Craniofacial Abnormalities Vitamin E 5.1419769572
MESH:D003456 Cryptorchidism Dibutyl Phthalate 10.8616037377
MESH:D003456 Cryptorchidism vinclozolin 10.8614966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.0318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.0318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5612868966 2524372 11298694 8156756 8970840 11906362 18759878 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.252952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 24.3421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 24.3418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 24.3418289764 7440962 18692083 8291058 9653073 11289319 6482804 16192314 9022650 1440618 6679447 9328219 18648102
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 24.3421346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 24.3416485898 19739265 16393943 16109766 11739529 10915739 19420014 11529661 10663392 14550746 16177239 11461765 19164858 16227642 12153990 16781746 11743745 11287661 12392966 12540782 12594235 19416960 10774834 18071297 15968718 17522070 15619225 11421492 17562736 14725611 19370779 11834606 19085960 12958197 18713872 17906064 19923254 12705907 2444490 14986274 16081117
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 24.3419107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 24.3417416283
MESH:D056486 Drug-Induced Liver Injury Selenium 24.3415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 24.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8319426721
MESH:D004362 Drug Toxicity Doxorubicin 7.4718602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.4711462148
MESH:C538011 Eales disease Vitamin E 4.449068938
MESH:D004487 Edema pirinixic acid 10.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.1111000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 10.118273558 15177302 9599246 11698051 16716910 7812673 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.0515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.0518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9412538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 11.7417359293
MESH:D016889 Endometrial Neoplasms Ethylenethiourea 11.747955072
MESH:D016889 Endometrial Neoplasms Tretinoin 11.7416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.809294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.8918037988
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8516302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.903581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9012903497
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.9015264214 15623463 15150132 15547721 15878914 16704527 15547733 16510608 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1911564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1916938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 22.1315073043
MESH:D005234 Fatty Liver Cyclosporine 22.1319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 22.1321071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.1315345470
MESH:D005234 Fatty Liver pirinixic acid 22.1320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2011858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.756705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.3219069698
MESH:D005355 Fibrosis Cyclosporine 13.2212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.2220067830
MESH:D005355 Fibrosis Tretinoin 13.2217994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0116904648
MESH:D005756 Gastritis Acetaminophen 3.4116983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.958708960
MESH:D005909 Glioblastoma Doxorubicin 6.6817150277
MESH:D005909 Glioblastoma Tretinoin 6.6817312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 10.667505956
MESH:D006042 Goiter perchlorate 10.6618801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3310696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.2615692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.2616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.3311294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.339664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 10.3316080930
MESH:D006331 Heart Diseases Doxorubicin 3.3116495754 16144979 16244372 16330681 16879835 12587719 17875725 17888722 14766674 16244371 18006777 16707910 18674790
MESH:D006333 Heart Failure Doxorubicin 10.8717481944
MESH:D006333 Heart Failure pirinixic acid 10.8720558911
MESH:D006333 Heart Failure Selenium 10.8717162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.6715692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.266705139
MESH:D006529 Hepatomegaly pirinixic acid 7.4116221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.4115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6116863852 16490937
MESH:D006689 Hodgkin Disease Doxorubicin 3.1915147373 18501091 17606976
MESH:D019584 Hot Flashes Vitamin E 3.7114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7816354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Acetaminophen 6.9416870215
MESH:D006930 Hyperalgesia Tretinoin 6.9416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3116778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9620558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.6815034207
MESH:D006973 Hypertension Cyclosporine 4.6110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6118670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.0917937319
MESH:D007248 Infertility, Male vinclozolin 6.0916467254
MESH:D007249 Inflammation Diethylnitrosamine 7.5718785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.5712200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 7.5711698051 7812673 7562506 15177302 8273558
MESH:D007251 Influenza, Human Selenium 10.0716624496
MESH:D007251 Influenza, Human Vitamin E 10.0716624496
MESH:D007333 Insulin Resistance pirinixic acid 2.4616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5117994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.758074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.1515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1715604871
MESH:D007674 Kidney Diseases Acetaminophen 13.1912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.1918776723 8314463 10903974
MESH:D007674 Kidney Diseases Doxorubicin 13.1916775033 15699352 15369732
MESH:D007674 Kidney Diseases Vitamin E 13.1912488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.2016707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.2016518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.0016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.0016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.006582329
MESH:D007680 Kidney Neoplasms Cyclosporine 16.0012371664
MESH:D007938 Leukemia arsenic trioxide 5.9015070760
MESH:D007938 Leukemia Tretinoin 5.9017143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.8916085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5612560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.6919077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.6919285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7120471514 16968895 16467208 17050201 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7116294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0716330433 15213294 17217047 19035177 17712046 11161223 15748426 16966277 16331271 19225113 12679006 16112521 15336539 17107899 15622746 16823087 12018890 19642359 17869043 11468182 12712474 17649720 19075265 9834237 16891316
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.0715748426 16823087 19642359 16788101 16331271 17339181 19029980 16891316 16766008 17107899 17301526 19075265 19225113 17361223 16140955 9834237 19035177 17649720 17368321 17712046 17217047 12679006 16935935 17506722 17294898
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1016882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.129224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.6820032147 19638242 18665156 18522880 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.3616595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3618397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.3616169303
MESH:D008107 Liver Diseases Acetaminophen 3.6712969438 11587558 19460945 16611625 19014921 12587719 19784758 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 3.6717034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0117185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.347678174
MESH:D008113 Liver Neoplasms arsenic trioxide 20.3414682389
MESH:D008113 Liver Neoplasms Clofibric Acid 20.3417602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.3421167192 19638242 2422723 20137499 2862719 12771043 20405173 20101389 19996281 15175105 19294768 19812893 19551842 18754104 19073162 20452335 21047994 20492335 16942905 18977376 20118626 18644402 20583210 19254457 19427195 19256749 21071580 19690152 20434301 21278145 19642983 10737359 15885732 19426721 19090486 12112319 18978307 19833225 19255062 19499222 20501860 9163691 19850985 18648771
MESH:D008113 Liver Neoplasms Ethylenethiourea 20.3411940454
MESH:D008113 Liver Neoplasms pirinixic acid 20.3415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.3416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 21.256135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 21.25598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 21.2520377131
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 21.2519519916 18775883 18253720 18544905 21159647 18079962 17854601 18093689 9362446 19539802 3124819 19009564 2563599 18308698 16842330 19004024 16267830 19126423 18164116 17942915 18282651 17174075
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 21.2516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.2512151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1515213294
MESH:D008171 Lung Diseases Vitamin E 3.0016863852
MESH:D008175 Lung Neoplasms arsenic trioxide 8.1111798837 19825857
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.1120970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 8.1117418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.1119555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.1111807781
MESH:D008175 Lung Neoplasms Vitamin E 8.1111062179
MESH:D008223 Lymphoma Doxorubicin 3.2816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.5817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3115621674
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 12.9911921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 12.9915458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 12.9915318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 12.998985016
MESH:D008527 Medulloblastoma Tretinoin 2.6817453147
MESH:D008545 Melanoma Doxorubicin 3.2816827129
MESH:D008545 Melanoma Tretinoin 3.2816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3119513568
MESH:D008591 Meningomyelocele Tretinoin 4.1716940565
MESH:D008654 Mesothelioma Doxorubicin 5.9417638057
MESH:D008654 Mesothelioma Selenium 5.9415107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.2615792986
MESH:D052016 Mucositis Doxorubicin 4.5317415656
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9219549372 19417148 11468182 15949261 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.2516239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.8916105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8917596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.3415857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.3419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7516411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.4718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.477678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7116624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.893581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.899029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.8918259882
MESH:D009369 Neoplasms 4-phenylbutyric acid 7.6419116145
MESH:D009369 Neoplasms pirinixic acid 7.6417405874
MESH:D009369 Neoplasms Tretinoin 7.6416594593 16946489
MESH:D009401 Nephrosis Doxorubicin 4.5116899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.5619348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.5616889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.6814600291
MESH:D009421 Nervous System Malformations Tretinoin 8.689125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.146679447
MESH:D009436 Neural Tube Defects arsenic trioxide 11.1410525206
MESH:D009436 Neural Tube Defects Tretinoin 11.149142499
MESH:D009447 Neuroblastoma Doxorubicin 3.1315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4818514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.4820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8520387270
MESH:D009765 Obesity pirinixic acid 1.7520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 19.7216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 19.7216049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 19.726482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 19.7214694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.753988306
MESH:D012516 Osteosarcoma Doxorubicin 3.9115930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.5919769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 4.5916936753
MESH:D010146 Pain Acetaminophen 5.8916870215
MESH:D010146 Pain Tretinoin 5.8916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.5615580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.5616540662
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 11.5615976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.5615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 8.547296757
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 8.5412065085 18922899 18404319 8330346
MESH:D010235 Paraganglioma arsenic trioxide 3.9219927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.206228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.8917983394
MESH:D010954 Plasmacytoma Selenium 4.6215087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.8917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3118163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.2112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.212563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6111896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.6118042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.6718220299
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7119131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7116888761 15749863 15897917 16868541 16729912 18437689
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7115084515
MESH:D011472 Prostatitis vinclozolin 4.6718629315
MESH:D011507 Proteinuria Tretinoin 3.3616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1416882103
MESH:D011625 Pterygium Tretinoin 4.5316723453
MESH:D051437 Renal Insufficiency Doxorubicin 3.9617922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5918990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.183692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8616116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.7617203757 18313854 16767912 15675481 17710206 15625365
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.4416646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.4414601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5317846226
MESH:D012640 Seizures 2,4-dinitrotoluene 5.2818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.2818551238
MESH:D012871 Skin Diseases Vitamin E 2.3718709164
MESH:D012878 Skin Neoplasms Doxorubicin 12.5815692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.5816192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.588330346 11807781 8985016 12065085 18404319
MESH:D012878 Skin Neoplasms Tretinoin 12.5816467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3117203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6816709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.5117007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5118456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.5117575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 4.5117261132
MESH:D020521 Stroke Vitamin E 3.3216517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 25.481399818 6582329 7505956 3712494 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 25.4819014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 25.487505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 25.4817909728 16010429
MESH:D013964 Thyroid Neoplasms Ethylenethiourea 25.4811940454
MESH:D013964 Thyroid Neoplasms Tretinoin 25.4816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5616051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7015213294
MESH:D014376 Tuberculosis Tretinoin 3.0716040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 14.6816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 14.6816049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.688074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 14.6812845720 12973940 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 14.6817653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.1110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.1110091137
MESH:D014581 Urticaria Acetaminophen 2.7410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0514692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3416752155
MESH:D014605 Uveitis Cyclosporine 3.721336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.9617638931 17334414 16364871 17678736
MESH:D014820 Vitiligo Tretinoin 3.8116761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9815886252
MESH:D009396 Wilms Tumor Tretinoin 3.7516287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1717120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved