AutismKB 2.0

Annotation Detail for MAGI1


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Basic Information Top
Gene Symbol:MAGI1 ( AIP3,BAIAP1,BAP1,MAGI-1,TNRC19,WWP3 )
Gene Full Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Band: 3p14.1
Quick LinksEntrez ID:9223; OMIM: 602625; Uniprot ID:MAGI1_HUMAN; ENSEMBL ID: ENSG00000151276; HGNC ID: 946
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MAGI1 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MAGI1 mRNAdecreases expression 20713471
D002117 Calcitriol Calcitriol results in decreased expression of MAGI1 mRNAdecreases expression 16002434
C025462 sulindac sulfide sulindac sulfide results in increased expression of MAGI1 mRNAincreases expression 12734198
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of MAGI1 mRNAdecreases expression 18087596
D014212 Tretinoin Tretinoin results in increased expression of MAGI1 mRNAincreases expression 18230668
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of MAGI1 mRNAincreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Zinc Sulfate 5.307265320
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420464547 20127859
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.9715814487
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D000505 Alopecia Tretinoin 3.8415955085
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1318759972
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D000860 Anoxia Zinc Sulfate 5.417265320
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.2316412693
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 5.0819898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.0816292516
MESH:D001249 Asthma Tretinoin 2.4116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.7316935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8916197459 16206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9220146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9211237771
MESH:D001943 Breast Neoplasms Tretinoin 1.9216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9916813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.6016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.973084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.971917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 6.3712391285
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 6.3711212258
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 11.4120419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 11.4111237771
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 11.4111212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 11.4116051514 16096774
MESH:D002386 Cataract Acetaminophen 7.7210977129
MESH:D002386 Cataract Tretinoin 7.7217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9916129372
MESH:D002822 Choriocarcinoma Tretinoin 5.6016461808
MESH:D002972 Cleft Palate Tretinoin 2.769407595
MESH:D003092 Colitis Tretinoin 4.0617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8310589399 9224671 16925845 9664655 17551590 8800419 9211117 9125849 9142499 14991402
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6511743745 14550746 2444490 15968718 19923254 16109766 10774834 14725611 18713872 12958197 16485898 11834606 19420014 12705907 19164858 19085960 12392966 16227642 10663392 18071297 19370779 17906064 15619225 11529661 17562736 16781746 16393943 19739265 12594235 16177239 12153990 11461765 11739529 16081117 12540782 11421492 14986274 19416960 10915739 17522070 11287661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004489 Edema, Cardiac Tretinoin 4.9118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.2615138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2816569247
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005124 Eye Abnormalities Tretinoin 3.789664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.8717994277
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Tretinoin 3.1717312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.6016084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0920471113
MESH:D006330 Heart Defects, Congenital Tretinoin 7.0914991402 9664655
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.3617063115
MESH:D006930 Hyperalgesia Acetaminophen 8.3716870215
MESH:D006930 Hyperalgesia Tretinoin 8.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.9316778211
MESH:D007022 Hypotension Zinc Sulfate 4.777265320
MESH:D007249 Inflammation Tobacco Smoke Pollution 3.4618590791
MESH:D007410 Intestinal Diseases Tretinoin 4.1217994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.1817551590 15992940
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.5015237267
MESH:D007938 Leukemia Tretinoin 2.8917143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3219029980 19035177 17368321 19075265 16766008 16788101 16140955 19642359 15748426 17294898 16331271 17649720 16935935 17361223 19225113 17339181 17217047 16891316 17301526 9834237 17506722 17107899 12679006 16823087 17712046
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.509224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 1.8118397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6812969438 16610002 19460945 11587558 19784758 12587719 19014921 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1220195826 21137059
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.7918520028 18816296 20869020 18569708 20135361 6695378 20464547 20064080 17053015
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 2.7912111688 16288123 3440675 11091918
MESH:D008527 Medulloblastoma Tretinoin 2.8717453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008591 Meningomyelocele Tretinoin 4.7816940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.5116381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 9.5115006635
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2217596541
MESH:D009369 Neoplasms Benzo(a)pyrene 5.3911141357
MESH:D009369 Neoplasms Tretinoin 5.3916946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 4.119125849
MESH:D009436 Neural Tube Defects Tretinoin 3.229142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4116936753
MESH:D010146 Pain Acetaminophen 7.3716870215
MESH:D010146 Pain Tretinoin 7.3716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5415976015
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1815572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2215754350 18247401 16289102 16644109 12479363
MESH:D011507 Proteinuria Tretinoin 3.9116636307
MESH:D011625 Pterygium Tretinoin 5.1916723453
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.9818410779
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.4016116481 16283617
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.2519755658 10029692
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 10.2518590791
MESH:D012878 Skin Neoplasms Tretinoin 10.2516467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.4020155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.4017261132
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2316026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0516051514
MESH:D014376 Tuberculosis Tretinoin 3.3816040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.6617053015
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 5.6612846360
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9416129372
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.9818645019
MESH:D014604 Uveal Neoplasms Tretinoin 5.0516752155
MESH:D014820 Vitiligo Tretinoin 4.3916761959
MESH:D009396 Wilms Tumor Tretinoin 4.2216287080
Pathway ID Pathway Name
KEGG:04530 Tight junction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA164742006
    • No data
    Releated disease ID Related disease Name
    PA443635Cardiovascular Diseases
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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