AutismKB 2.0

Annotation Detail for DLGAP1


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Basic Information Top
Gene Symbol:DLGAP1 ( DAP-1,DAP-1-ALPHA,DAP-1-BETA,GKAP,MGC88156,SAPAP1,hGKAP )
Gene Full Name: discs, large (Drosophila) homolog-associated protein 1
Band: 18p11.31
Quick LinksEntrez ID:9229; OMIM: 605445; Uniprot ID:DLGP1_HUMAN; ENSEMBL ID: ENSG00000170579; HGNC ID: 2905
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DLGAP1 mRNAaffects expression 16483693
D002117 Calcitriol Calcitriol results in increased expression of DLGAP1 mRNAincreases expression 16002434
D006918 Hydroxyurea Hydroxyurea results in increased mutagenesis of DLGAP1 geneincreases mutagenesis 16868089
D008770 Methylnitrosourea Methylnitrosourea results in increased mutagenesis of DLGAP1 geneincreases mutagenesis 16868089
C025643 vinclozolin vinclozolin affects the expression of DLGAP1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.1018287403
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.1915113128 15688392
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D001943 Breast Neoplasms Calcitriol 2.6111237771
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.6116253758 14633655 11306469
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.7011237771
MESH:D002386 Cataract Methylnitrosourea 4.1712484553
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 4.032727394 7505956
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3715138306
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.7711555667
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D005910 Glioma Methylnitrosourea 3.679825942
MESH:D007248 Infertility, Male Methylnitrosourea 7.907193160
MESH:D007248 Infertility, Male vinclozolin 7.9016467254
MESH:D007951 Leukemia, Myeloid Hydroxyurea 5.3816532439
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.4515526292
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.9516080182
MESH:D008175 Lung Neoplasms Methylnitrosourea 2.7018062963
MESH:D008223 Lymphoma Methylnitrosourea 4.2616257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 5.1714633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.7910767621 11807958 10838139 15313902 12931682 15113128 16619500 11751437 16944150 15688392 16051031 14633655 14999141 16827153 17131329 17020996 19196723
MESH:D009369 Neoplasms Methylnitrosourea 3.4515533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.9512696579
MESH:D009442 Neurilemmoma Methylnitrosourea 6.0311555667
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 3.4616965848
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.4419015723 18042343 18220299
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.3215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.6218247401 12479363 15754350 16289102 16644109
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.6215682402 12376480
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.6718155124 18172121
MESH:D012175 Retinoblastoma Methylnitrosourea 6.0311555667
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7018593901 15930296 16257854
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.7711418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 4.197505956 3078959
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018