AutismKB 2.0

Annotation Detail for DLG5


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Basic Information Top
Gene Symbol:DLG5 ( KIAA0583,LP-DLG,P-DLG5,PDLG )
Gene Full Name: discs, large homolog 5 (Drosophila)
Band: 10q22.3
Quick LinksEntrez ID:9231; OMIM: 604090; Uniprot ID:DLG5_HUMAN; ENSEMBL ID: ENSG00000151208; HGNC ID: 2904
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1998Enteritis
2106Pancreas cancer
2171Celiac disease
Desease Name
Crohn's disease and IBD
inflammatory bowel disease
IMMUNE
Crohn's disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of DLG5 mRNAaffects expression 17562736
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNAaffects cotreatment|increases expression 18606552
D011397 Promegestone methoxyacetic acid promotes the reaction [Promegestone results in increased expression of DLG5 mRNA]increases expression|increases reaction 15103026
D011397 Promegestone Promegestone results in increased expression of DLG5 mRNAincreases expression 15103026
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of DLG5 mRNAaffects cotreatment|increases expression 18606552
C013598 methoxyacetic acid methoxyacetic acid promotes the reaction [Promegestone results in increased expression of DLG5 mRNA]increases expression|increases reaction 15103026
D015741 Metribolone Metribolone results in increased expression of DLG5 mRNAincreases expression 17010196
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DLG5 mRNAaffects binding|increases activity|increases expression 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of DLG5 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced methoxyacetic acid 9.961761407 1761404 3652986 15959878 12805644
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.9611752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 11.0516835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D009202 Cardiomyopathies Zalcitabine 4.8610591146
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1915668235 15340226 16354765 12621046 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7516109766 19739265 17522070 11529661 14725611 10915739 12958197 11287661 11834606 14550746 12705907 12540782 10774834 11739529 16081117 16393943 11461765 19420014 18071297 10663392 15968718 12153990 11421492 11743745 17906064 12594235 19370779 12392966 17562736 19164858 19085960 15619225 16227642 16485898 19416960 19923254 14986274 18713872 16781746 2444490 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 9.1311462148
MESH:D004362 Drug Toxicity Zalcitabine 9.137515130
MESH:D004487 Edema pirinixic acid 7.3512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.3512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver pirinixic acid 9.0720131406 19236843
MESH:D005234 Fatty Liver Zalcitabine 9.0718299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.2520067830
MESH:D005532 Foot Deformities, Congenital methoxyacetic acid 6.003652986
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4411294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly pirinixic acid 9.3016221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.3016120746 12621046 15340226
MESH:D015658 HIV Infections Zalcitabine 4.4517457083
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4218606429 16959395 15340226 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D015212 Inflammatory Bowel Diseases marker/mechanism
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D017880 Limb Deformities, Congenital methoxyacetic acid 4.9012805644 15959878
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1912878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 11587558 19014921 16611625 19784758 12587719 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 4.5120007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008223 Lymphoma Zalcitabine 4.819205081 18798262 8840982 11980663 8764131 9488045 17941976
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009369 Neoplasms pirinixic acid 2.0517405874
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.419205081 9488045 8764131
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009437 Neuralgia Zalcitabine 6.6517292584
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 11.8918606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 11.8918606552
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311118676 11399792 11896295 11222880
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013576 Syndactyly methoxyacetic acid 5.911761407 1761404
MESH:D013733 Testicular Diseases methoxyacetic acid 5.6718486176 6499806
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27360
    • No data
    Releated disease ID Related disease Name
    PA443815Crohn Disease
    PA446116Inflammatory Bowel Diseases
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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