AutismKB 2.0

Annotation Detail for IL32


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Basic Information Top
Gene Symbol:IL32 ( IL-32alpha,IL-32beta,IL-32delta,IL-32gamma,NK4,TAIF,TAIFa,TAIFb,TAIFc,TAIFd )
Gene Full Name: interleukin 32
Band: 16p13.3
Quick LinksEntrez ID:9235; OMIM: 606001; Uniprot ID:IL32_HUMAN; ENSEMBL ID: ENSG00000008517; HGNC ID: 16830
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1781Rheumatoid arthritis
1807Autoimmune disease
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C501474 4-OH-2',3,3',4',5'-pentachlorobiphenyl 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of IL32 mRNA]decreases reaction|increases expression 14761676
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IL32 proteinaffects expression 20106945
D001151 Arsenic IL32 mRNA results in decreased susceptibility to Arsenicdecreases response to substance 17976673
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of IL32 mRNAaffects expression 20106945
D002392 Catechin Catechin results in decreased expression of IL32 mRNAdecreases expression 15465739
C423222 cotylenin A cotylenin A results in increased expression of IL32 mRNAincreases expression 16129123
D016572 Cyclosporine Cyclosporine results in decreased expression of IL32 mRNAdecreases expression 20106945
D004391 Dust Dust results in increased expression of IL32 mRNAincreases expression 17805423
D004958 Estradiol Estradiol affects the expression of IL32 mRNAaffects expression 14699072
C029938 nickel sulfate nickel sulfate results in increased expression of IL32 mRNAincreases expression 16780908
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of IL32 mRNA]decreases reaction|increases expression 14761676
D013467 Sulindac Sulindac inhibits the reaction [CDKN1A protein results in increased expression of IL32 mRNA]decreases reaction|increases expression 15190207
D014284 Triiodothyronine 4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of IL32 mRNA]decreases reaction|increases expression 14761676
D014284 Triiodothyronine Polychlorinated Biphenyls inhibits the reaction [Triiodothyronine results in increased expression of IL32 mRNA]decreases reaction|increases expression 14761676
D014284 Triiodothyronine Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of IL32 mRNA]increases expression|increases reaction 14761676
D014284 Triiodothyronine Triiodothyronine results in increased expression of IL32 mRNAincreases expression 14761676
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in increased expression of IL32 mRNA]increases expression|increases reaction 14761676
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IL32 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.5914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 14514962 11752688
MESH:D058186 Acute Kidney Injury Sulindac 4.377897758
MESH:D055371 Acute Lung Injury nickel sulfate 4.3716100012 11954676 12718980 19131640
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2620464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 7.2611473722
MESH:D000230 Adenocarcinoma Sulindac 7.2611910360
MESH:D000236 Adenoma Benzo(a)pyrene 7.076695378
MESH:D000236 Adenoma Sulindac 7.0710223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4616835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.6519003578 11874996 15623613 11535846 17611924 12394442 16460482
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3117306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8818414634 12569548 16835338 16251483
MESH:D050197 Atherosclerosis Arsenic 3.2812928151 19371607
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001913 Bowen's Disease Sulindac 5.4511207687
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9717474063 20146248
MESH:D001943 Breast Neoplasms Estradiol 1.9717261762 17289903 14630087 12948864 16675129 17018787 18497071 19861407
MESH:D001943 Breast Neoplasms Sulindac 1.9716642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6215504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7012907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7017306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7016924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.7618922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7620419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1318640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.4815738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.3616973168 18022660
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7018566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 2.9519486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215340226 16354765 8697196 15668235 12621046
MESH:D003110 Colonic Neoplasms Sulindac 2.9312458338 12902858
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.1315531428
MESH:D015179 Colorectal Neoplasms Sulindac 3.1310666051 18059344 11197048 11076880
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003704 Dementia Polychlorinated Biphenyls 4.7516140633
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.7416823706 16780908 11298694
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D003930 Diabetic Retinopathy Sulindac 5.2417621415 12861449
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0016714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.0111473722 18566989 19148513
MESH:D004715 Endometriosis Sulindac 9.3615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.369294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7816530937
MESH:D004938 Esophageal Neoplasms Sulindac 4.7812235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 2.9119224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.5614745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.2119069698
MESH:D005355 Fibrosis Cyclosporine 8.7212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005534 Foot Diseases Arsenic 5.666392382
MESH:D005764 Gastroesophageal Reflux Sulindac 5.0711910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5411294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.9615340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1415340226 16354765 8697196 18606429 16959395
MESH:D020138 Hyperhomocysteinemia Catechin 5.0217292331
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5117050553
MESH:D006973 Hypertension Arsenic 8.6916076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 8.6910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.6918670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.6616093927
MESH:D007249 Inflammation Sulindac 5.333291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0016627594 16393666
MESH:D007414 Intestinal Neoplasms Sulindac 4.6912584176 10223192 10213222 12628509 12351151 12663524
MESH:D007417 Intestinal Polyps Sulindac 5.0511245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007642 Keratosis Arsenic 5.0712749816 16930632
MESH:D007674 Kidney Diseases Cyclosporine 6.048314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.0415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D007680 Kidney Neoplasms Estradiol 7.4215610895
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5917339181
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.2612468960
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.2714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.2712878042
MESH:D008107 Liver Diseases Arsenic 4.6211134558
MESH:D008107 Liver Diseases Sulindac 4.6216867024 14986274
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.872125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Arsenic 10.8716368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.8721137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.148603461
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 10.141423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1412151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.6714755239
MESH:D008175 Lung Neoplasms Arsenic 6.6717306315 17976673 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6718569708 18520028 20464547 6695378 18816296 20135361 20064080 20869020 17053015
MESH:D008175 Lung Neoplasms Sulindac 6.6715713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6711884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5911807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008545 Melanoma Sulindac 2.8416642371
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D017202 Myocardial Ischemia Arsenic 9.1515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.1512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3216810080
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1911141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.6811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D009436 Neural Tube Defects Arsenic 3.4916620997
MESH:D019636 Neurodegenerative Diseases Sulindac 4.3117266991 16850258
MESH:D020078 Neurogenic Inflammation Arsenic 4.4317056641
MESH:D010051 Ovarian Neoplasms Arsenic 5.0017306315
MESH:D010051 Ovarian Neoplasms Estradiol 5.0019401270
MESH:D010146 Pain Sulindac 3.833291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.3716820089 11504793
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4116702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.0715371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711399792 11896295 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.1116140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.1115721890
MESH:D011507 Proteinuria Arsenic 4.0621343184
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012871 Skin Diseases Arsenic 2.7616759981 19834688 15952646 17938729 6392382 17453740 16702368 17548696 17050553 16353154 18709164
MESH:D012878 Skin Neoplasms Arsenic 9.5817976673 15504454 17029826 16251483 17050553 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.5819755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.5816192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.2319322015 18640142 11144890 19429237 17976673 15987713 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2317053015
MESH:D014594 Uterine Neoplasms Sulindac 4.6618645019
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014652 Vascular Diseases Arsenic 4.8217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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