AutismKB 2.0

Annotation Detail for NOG


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Basic Information Top
Gene Symbol:NOG ( SYM1,SYNS1 )
Gene Full Name: noggin
Band: 17q22
Quick LinksEntrez ID:9241; OMIM: 602991; Uniprot ID:NOGG_HUMAN; ENSEMBL ID: ENSG00000183691; HGNC ID: 7866
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04350TGF-beta signaling pathway
Pathway IDPathway Name
Signaling by BMP
Pathway IDPathway Name
200123BMP receptor signaling
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1827Bone metastases
1865Hyperopia
2067Primary tumor
2201Myeloproliferative disease
2209Ankylosis
2224Rhabdomyosarcoma
Desease Name
nonsyndromic cleft lip with or without cleft palate
height
DEVELOPMENTAL
Desease Name
Height
Nonsyndromic cleft lip with or without cleft palate
Desease Name
Stapes ankylosis with broad thumb and toes
Brachydactyly, type B2
Symphalangism, proximal
Synostoses syndrome, multiple, 1
Tarsal-carpal coalition syndrome
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of NOG mRNAdecreases expression 17327690
D000082 Acetaminophen Acetaminophen affects the expression of NOG mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NOG mRNAaffects expression 16483693
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NOG mRNAaffects cotreatment|decreases expression 20360939
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NOG mRNAaffects cotreatment|decreases expression 20360939
C056599 icariin NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]decreases expression|decreases reaction 19747809
C056599 icariin NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]decreases reaction|increases expression 18295595
C056599 icariin NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA]decreases reaction|increases expression 19747809
C056599 icariin NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]decreases reaction|increases expression 18295595
19747809
C056599 icariin NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]decreases reaction|increases expression 19747809
C056599 icariin NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]decreases reaction|increases expression 18295595
C056599 icariin NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA]decreases reaction|increases expression 19747809
C006253 pirinixic acid pirinixic acid results in increased expression of NOG mRNAincreases expression 12832660
D014212 Tretinoin [Tretinoin co-treated with EGF protein co-treated with NOG protein] results in increased expression of SOX10 mRNAaffects cotreatment|increases expression 17196394
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.3818653653
MESH:D000236 Adenoma Diethylnitrosamine 2.986695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 11.2418056438 19052882 17620307 16434500 17162532 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.2416434500
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000544 Alzheimer Disease icariin 3.8019782061 19858766
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.8019483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.8016197459 16206674
MESH:D001847 Bone Diseases icariin 6.7418295595
OMIM:611377 BRACHYDACTYLY, TYPE B2 marker/mechanism
MESH:D002545 Brain Ischemia icariin 5.8119303870
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1517474063
MESH:D001943 Breast Neoplasms Tretinoin 2.1516873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7119107877 16878318 19394651 17761372 21159647 19171122 18393292 10672840 16807293 20514400 17428255 16698587 19519916 17138121 18691550 16540662 19335982 16935385 16681979 17978847 20101231 19539802 18210153 17055752 10737359 20727157 18665156 19208518 20007298 18506893 19052882 16328049 3084413 16569478 19701751 16830150 3581430 20214788 19822196 16502159 20935162 19919837 20432363 18788625 19418558 16288022 11831363 17173139 18494052 18978308 20512989 20084675 18056438 16779866 17162532 18785209 18971187 20524982 19383236
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.711917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416096774 16051514
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Tretinoin 7.6617460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0117174075 7505956 2727394 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D002779 Cholestasis pirinixic acid 3.0019176532
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8317551590 9664655 10589399 9211117 16925845 9125849 8800419 9224671 14991402 9142499
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9419370779 14550746 2444490 18713872 16081117 11743745 16485898 11739529 16227642 12392966 17522070 12594235 19923254 11529661 19739265 10663392 14986274 19164858 16781746 15619225 11287661 10774834 16109766 12540782 11421492 12153990 17562736 17906064 11834606 19420014 14725611 12958197 19416960 10915739 16393943 18071297 16177239 15968718 11461765 12705907 19085960
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9419107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004487 Edema pirinixic acid 2.7212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D007172 Erectile Dysfunction icariin 5.7115329286 16281085
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005124 Eye Abnormalities Tretinoin 3.759664655 16938888
MESH:D005234 Fatty Liver Diethylnitrosamine 8.5021071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 8.5020131406 19236843
MESH:D005355 Fibrosis Tretinoin 3.8217994277
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0114991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.6720558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3019176532 19772884 16221962 18467677
MESH:D006930 Hyperalgesia Acetaminophen 8.2716870215
MESH:D006930 Hyperalgesia Tretinoin 8.2716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.4120558911
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007333 Insulin Resistance pirinixic acid 2.7816306350
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8110783313
MESH:D007569 Jaw Abnormalities Tretinoin 4.1415992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.6615629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.6615369732
MESH:D007859 Learning Disorders icariin 5.6219782061
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 8.4216766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.4215748426 16788101 12679006 19642359 16935935 17217047 16766008 17294898 16140955 17649720 19029980 19035177 17301526 17712046 17506722 16823087 19225113 19075265 16331271 17107899 16891316 17361223 17368321 17339181 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9418522880 19638242 20032147 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.4018397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 4.0816611625 12587719 19014921 16610002 19460945 11587558 12969438 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.7020137499 19833225 12771043 9163691 20583210 19850985 20101389 19256749 19255062 21071580 19690152 15885732 21278145 20118626 12112319 19426721 18648771 20405173 18977376 10737359 19996281 19551842 19254457 21167192 19499222 20492335 19638242 19073162 19294768 21047994 15175105 18978307 20452335 20501860 19812893 19427195 2422723 18644402 2862719 19090486 16942905 18754104 20434301 19642983
MESH:D008113 Liver Neoplasms pirinixic acid 4.7020007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7718544905 9362446 18775883 19004024 19519916 17942915 18282651 18253720 18079962 21159647 19009564 18308698 16267830 17854601 19539802 17174075 19126423 16842330 18093689 2563599 3124819 18164116
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7621163286 20970405 6695378 20512841
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008569 Memory Disorders icariin 5.5819782061
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:C537379 Multiple synostoses syndrome 1 marker/mechanism
MESH:D009135 Muscular Diseases pirinixic acid 3.8116239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2219151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1316411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.659029167 3581430
MESH:D009369 Neoplasms pirinixic acid 5.2617405874
MESH:D009369 Neoplasms Tretinoin 5.2616594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.069125849
MESH:D009436 Neural Tube Defects Tretinoin 3.209142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010024 Osteoporosis icariin 4.7519747809 18236786
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4016936753
MESH:D010146 Pain Acetaminophen 7.2616870215
MESH:D010146 Pain Tretinoin 7.2616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4916540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4915976015
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D011507 Proteinuria Tretinoin 3.8616636307
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4919058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616283617 16116481
MESH:D012878 Skin Neoplasms Tretinoin 2.7016467112
OMIM:184460 STAPES ANKYLOSIS WITH BROAD THUMB AND TOES marker/mechanism
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4718456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.4717261132
OMIM:185800 SYMPHALANGISM, PROXIMAL marker/mechanism
OMIM:186570 TARSAL-CARPAL COALITION SYNDROME marker/mechanism
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.787505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.7816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
Pathway ID Pathway Name
REACT:12034 Signaling by BMP
KEGG:04350 TGF-beta signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA31670
    • No data
    Releated disease ID Related disease Name
    PA152530793Brachydactyly type B
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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