AutismKB 2.0

Annotation Detail for GCNT3


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Basic Information Top
Gene Symbol:GCNT3 ( C2/4GnT,C24GNT,C2GNT2,C2GNTM,GNTM )
Gene Full Name: glucosaminyl (N-acetyl) transferase 3, mucin type
Band: 15q22.2
Quick LinksEntrez ID:9245; OMIM: 606836; Uniprot ID:GCNT3_HUMAN; ENSEMBL ID: ENSG00000140297; HGNC ID: 4205
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00512O-Glycan biosynthesis
hsa01100Metabolic pathways
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GCNT3 mRNAaffects expression 16483693
D000965 Antimony Antimony results in increased expression of GCNT3 mRNAincreases expression 17547211
D000966 Antimony Potassium Tartrate Antimony Potassium Tartrate results in increased expression of GCNT3 mRNAincreases expression 17547211
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of GCNT3 mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GCNT3 mRNAincreases expression 20106945
19737606
D016572 Cyclosporine Cyclosporine results in increased expression of GCNT3 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in increased expression of GCNT3 mRNAincreases expression 16002434
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of GCNT3 mRNAincreases expression 17547211
D004958 Estradiol Estradiol results in increased expression of GCNT3 mRNAincreases expression 20106945
C022838 nickel chloride nickel chloride results in increased expression of GCNT3 mRNAincreases expression 17547211
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GCNT3 mRNAaffects binding|decreases expression|increases activity 19710929
D018038 Sodium Selenite Sodium Selenite results in decreased expression of GCNT3 mRNAdecreases expression 18175754
D014284 Triiodothyronine Triiodothyronine results in decreased expression of GCNT3 mRNAdecreases expression 19228888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GCNT3 mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6418287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2220127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 7.2216033868
MESH:D000230 Adenocarcinoma Estradiol 7.2211473722
MESH:D000236 Adenoma Benzo(a)pyrene 11.486695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.4819389873
MESH:D000236 Adenoma Dimethylnitrosamine 11.4819555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1816835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9420146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9411237771
MESH:D001943 Breast Neoplasms Estradiol 1.9418497071 17261762 19861407 16675129 12948864 17018787 17289903 14630087
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D001991 Bronchitis Antimony 6.238768112
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5516111702
MESH:D002277 Carcinoma Dimethylnitrosamine 8.5019555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7716924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7220419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.7211237771
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.7216033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Antimony 3.9410334427
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7012371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.7018566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 7.8919486331
MESH:D002779 Cholestasis pirinixic acid 7.8919176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1215668235 15340226 12621046 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4619279558
MESH:D004283 Dog Diseases Antimony 5.7412019027
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 6.408172417
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.4015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0015138306
MESH:D016889 Endometrial Neoplasms Estradiol 3.0111473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7016530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.7017016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Cyclosporine 7.7419224547
MESH:D005234 Fatty Liver pirinixic acid 7.7419236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Cyclosporine 8.7212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.7220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.5016221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1315709030
MESH:D019584 Hot Flashes Estradiol 3.8517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 16354765 15340226 18606429 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 12.5216627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.5216306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.5214714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 6.0418776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 6.0415618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4212371664
MESH:D007680 Kidney Neoplasms Estradiol 7.4215610895
MESH:D007896 Leishmaniasis Antimony 4.8610953559 15220340 12019027 21182181 21063981
MESH:D016773 Leishmaniasis, Cutaneous Antimony 4.718889330 11475954 19141829
MESH:D007897 Leishmaniasis, Mucocutaneous Antimony 5.579643325 10881086 10651420 11370249 7854095
MESH:D007898 Leishmaniasis, Visceral Antimony 8.8711105143 1899875 7854095 7875148 8142506 20495762 7554475
MESH:D007898 Leishmaniasis, Visceral Antimony Potassium Tartrate 8.8712707265
MESH:D015473 Leukemia, Promyelocytic, Acute Antimony Potassium Tartrate 4.559834237
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 5.0018210741 14568256 17196135 16570917 18237412 18629640 16042886 15723089 17432682 15798949 15842777 15577212 17881167 15504291 12925901 15793283 15864749 15744066 15733078 17534399 12918455 15571005 18364076 16169303 15081153 15161499 17036385 14643895 18371158 16603200 15086199 15591649 16270385 18239293 15298665 16009107 17348192 17203207 17640959 17198567 18567088 17724770 17465448 16627068 16544323 15369754 15492853 14726149 18672772 18095165 15339415 17201889 15099470 17719030 15067225 15383259 17666798 15763062 14659978 15479170 18637143 14709902 15366600 15138612 15942678
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0012878042
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.4617457977
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.4620195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 14.4619389873 21295105
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 14.4615890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 14.4616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4616984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.1518164116
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 10.151848544 6150874 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1512151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4718520028 18816296 17053015 20464547 6695378 18569708 20135361 20869020 20064080
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 3.4716061637 11884234 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4719555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5917203775 11807958 11408345 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.5819453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3916411023
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8117289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.6816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.6814600291
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010051 Ovarian Neoplasms Estradiol 2.2319401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010409 Penile Diseases Antimony 5.799643325
MESH:D010493 Pericarditis Antimony 6.2020465667
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11399792 11222880 11118676
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8615572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9420887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0716289102 15754350 12479363 18247401 16644109
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.0718760546
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.3712587719
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.6020155912 2093021
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.6016033868
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013978 Tibial Fractures Estradiol 4.7819048282
MESH:D014352 Trypanosomiasis Antimony 6.0315220340
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2017053015
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00512 Mucin type O-Glycan biosynthesis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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